Cheap Flights to Sikeston from $50

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How Much Does it Cost To Fly To Sikeston?

The cheapest prices found with in the last 7 days for return flights were $73 and $50 for one-way flights to Sikeston for the period specified. Prices and availability are subject to change. Additional terms apply

Mon, Apr 27 - Wed, Apr 29
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$129 Roundtrip, found 6 days ago
$129
Roundtrip
found 6 days ago
Select Delta flight, departing Mon, Apr 27 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, Apr 29, priced at $129 found 6 days ago
OriginDestinationTravel DatesFlights From*
DENSt. LouisApril 18 to April 25$73
ATLSt. LouisApril 15 to April 15$78
DFWSt. LouisApril 20 to April 20$80
DFWScott CityMay 15 to May 18$140
EWRSt. LouisMay 3 to May 7$160
SEASt. LouisApril 8 to April 21$177
LAXSt. LouisMay 9 to May 15$190
LGAWest PaducahApril 2 to April 6$307
LGAWest PaducahApril 2 to April 6$307
EWRScott CityMay 5 to May 8$425
TPAWest PaducahMarch 16 to March 17$670
LAXWest PaducahApril 6 to April 9$715
LAXScott CityMay 9 to May 17$781
FCOSt. LouisApril 8 to April 17$860
ATLScott CityMarch 18 to March 20$1,518
*Prices include taxes and fees
OriginDestinationTravel DatesFlights From*
PHLSt. LouisMarch 8 to March 10$251
TPASt. LouisMarch 8 to March 12$279
LGASt. LouisMarch 7 to March 11$286
LGASt. LouisMarch 7 to March 11$286
ATLSt. LouisMarch 8 to March 11$286
DENSt. LouisMarch 7 to March 28$306
DFWSt. LouisMarch 7 to March 9$360
DFWScott CityMarch 8 to March 9$399
LAXSt. LouisMarch 8 to March 10$502
SEASt. LouisMarch 7 to March 17$586
*Prices include taxes and fees

Sikeston Flight Information

Traveling to
Sikeston
Lowest Price
$73
Number of Airlines Serving
Airlines Serving
United, Delta
Number of Daily Flights
Airlines with Direct Flights

Find The Perfect Hotel For After Your Flight

Amazing Sikeston Accommodation Deals

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
$72 nightly
The price is $81 total per night from Mar 9 to Mar 10
$81 total
Mar 9 - Mar 10
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,006 reviews)
Yes to all the above.

Reviewed on Mar 2, 2026

Opens in a new windowPear Tree Inn Cape Girardeau West
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
$76 nightly
The price is $86 total per night from Mar 8 to Mar 9
$86 total
Mar 8 - Mar 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,003 reviews)
Rooms were clean. Close to our event.

Reviewed on Mar 1, 2026

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street Cape Girardeau MO
$95 nightly
The price is $107 total per night from Mar 15 to Mar 16
$107 total
Mar 15 - Mar 16
Total with taxes and fees
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,004 reviews)
Everything was excellent. Staff was very friendly and helpful.

Reviewed on Mar 5, 2026

Opens in a new windowHoliday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
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Eagle Inn Charleston

Eagle Inn Charleston

2 out of 5
2811 East Marshall Street Charleston MO
$64 nightly
The price is $71 total per night from Mar 6 to Mar 7
$71 total
Mar 6 - Mar 7
Total with taxes and fees
Stay at this motel in Charleston. Enjoy free WiFi, free parking, and a health club.
6.6/10 (105 reviews)
The hotel needs a renovation. For the price I didn’t expect much, but it feels neglected.

Reviewed on Dec 17, 2025

Opens in a new windowEagle Inn Charleston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
$76 nightly
The price is $86 total per night from Mar 8 to Mar 9
$86 total
Mar 8 - Mar 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,003 reviews)
Rooms were clean. Close to our event.

Reviewed on Mar 1, 2026

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, a water park, and laundry facilities. Popular attractions Riverfront Park and eDen Spa & Salon are ...
10/10 Exceptional! (224 reviews)
Great location, quality bedding and pillows, and other comfortable amenities for a short getaway in historic downtown Cape Girardeau. Excellent value!

Reviewed on Dec 15, 2025

Get rates
Opens in a new windowHistorical 'Kage House' Short Term Rental located in "Old Town Cape"
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

2.5 out of 5
2011 North Kingshighway Cape Girardeau MO
$60 nightly
The price is $68 total per night from Mar 11 to Mar 12
$68 total
Mar 11 - Mar 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
7.2/10 Good! (706 reviews)
Noisy. Could hear noise from parking lot and from upstairs. Did not like required refundable $50 deposit. After hearing a shower running from another room, our shower leaked from the wall connection. Staff said there was no one available to fix. Staff offered to move us. but we were unpacked ready ...

Reviewed on Mar 4, 2026

Opens in a new windowQuality Inn Cape Girardeau North
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Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$94 nightly
The price is $108 total per night from Mar 10 to Mar 11
$108 total
Mar 10 - Mar 11
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,008 reviews)
Plenty of good parking. Good food choices nearby. Very comfortable rooms

Reviewed on Mar 4, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$94 nightly
The price is $108 total per night from Mar 10 to Mar 11
$108 total
Mar 10 - Mar 11
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,008 reviews)
Plenty of good parking. Good food choices nearby. Very comfortable rooms

Reviewed on Mar 4, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
$82 nightly
The price is $93 total per night from Mar 26 to Mar 27
$93 total
Mar 26 - Mar 27
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,005 reviews)
We started our stay with a hostile guest while trying to check in. The lack of care from the worker at check in was a new level of IDGAF, the following day they turned our

Reviewed on Mar 2, 2026

Opens in a new windowBest Western Plus Sikeston I-55
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
$90 nightly
The price is $102 total per night from Mar 10 to Mar 11
$102 total
Mar 10 - Mar 11
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,006 reviews)
Great as all Drury’s

Reviewed on Mar 4, 2026

Opens in a new windowDrury Inn & Suites Cape Girardeau
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Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd Jackson MO
$92 nightly
The price is $100 total per night from Mar 8 to Mar 9
$100 total
Mar 8 - Mar 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
Opens in a new windowComfort Suites Jackson-Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best Sikeston Flight and Hotel Packages

Sikeston flight + hotel packages - economy flights

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was $701, price is now $478 per person
$478
per person
Apr 15 - Apr 18
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
Hilton Pennywell St. Louis at the Arch

Hilton Pennywell St. Louis at the Arch

4 out of 5
Price was $746, price is now $581 per person
$581
per person
Apr 23 - Apr 26
found 1 day ago
Roundtrip flight included
Philadelphia (PHL) to St. Louis (STL)
Hotel Saint Louis, Autograph Collection

Hotel Saint Louis, Autograph Collection

4 out of 5
Price was $742, price is now $579 per person
$579
per person
Apr 8 - Apr 11
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
Don't see what you're looking for?
See all available trips from Newark Liberty Intl. Airport to Sikeston
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Need a Car For After Your Flight?

Compact

  • 5 people
  • Unlimited mileage
ST. LOUIS, USA

$37

$96 total
found 2 days ago
Compact undefined

Fullsize

  • 5 people
  • Unlimited mileage
ST. LOUIS, USA

$37

$96 total
found 2 days ago
Fullsize undefined

Midsize

  • 5 people
  • Unlimited mileage
ST. LOUIS, USA

$37

$96 total
found 2 days ago
Midsize undefined

Economy

  • 4 people
  • Unlimited mileage
St Louis, Missouri, USA

$37

$96 total
found 2 days ago
Economy undefined
Lowest prices found within the past 2 days. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Which airlines fly to Sikeston?
You won't find many airlines that service Sikeston. So, if you're planning to embark on your long-anticipated adventure from here, book a seat with Cape Air as soon as you can.
Where to stay in Sikeston
Lock in your Sikeston accommodations through Travelocity and then turn your attention to what really matters — creating remarkable travel memories. Pick from 12 lodgings from which you can explore this enticing destination.If you're on the hunt for the top accommodation options in Sikeston, we suggest the Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel and the Hampton Inn Sikeston. Reserve a room and then start booking all your exciting getaway activities.
Places to visit in Sikeston
Every visitor will hear talk of The Book Bug at least once. It's a well-known local store. Like some more ideas? Lovers of painting should plan to pay a visit to Sikeston Depot Museum where they'll certainly be impressed. But that's not all there is. Central Park is an urban sanctuary. It is a beautiful place to go for a jog and enjoy the outdoors.
How to get through airport security fast when traveling to Sikeston
Your adventure to Sikeston starts as soon as you've finished all the security checks. Here are some tips and pointers to help you get through quickly:

  • Security personnel will ask to see your travel ID and boarding pass as part of their checks. Tuck them away in a convenient place, so they're all ready for inspection.
  • Remove your shoes and belt before arriving at the airport security checkpoint. Items like these are not permitted to pass through the body scanner.
  • Make sure your phone, laptop and other electronic devices are easily accessible. These items need to be sent through the X-ray machine separately.
  • When you approach the security checkpoint, you'll be asked to place all creams, gels and liquids in a separate tray for scanning. Make sure they're all packed in containers smaller than 3.4 ounces (100 milliliters) and sealed in a clear zip-lock bag.
  • Security personnel will likely tell you to take off your shoes for the body scanner. Choose a pair that you can slip off easily. There's nothing more irritating than having to do your laces up over and over again.
  • Pocketknives and corkscrews are not permitted on board the aircraft. Tuck them away in your checked luggage to avoid them being confiscated at the airport security checkpoint.

Plane Tickets To Sikeston

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Sikeston. Browse through our inventory to explore a wide range of cheap flights to Sikeston to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Sikeston as you anxiously await to exit the plane and explore what Sikeston has to offer. Considering all the amazing local food and culture in Sikeston, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Sikeston to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Sikeston without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Sikeston with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Sikeston today!

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*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.