Cheap Flights to Sikeston from $64

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How Much Does it Cost To Fly To Sikeston?

The cheapest prices found with in the last 7 days for return flights were $58 and $64 for one-way flights to Sikeston for the period specified. Prices and availability are subject to change. Additional terms apply

Wed, Jan 28 - Wed, Feb 4
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$148 Roundtrip, found 6 hours ago
$148
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Wed, Jan 28 from San Francisco Intl. to Lambert-St. Louis Intl., returning Wed, Feb 4, priced at $148 found 6 hours ago
OriginDestinationTravel DatesFlights From*
DENSt. LouisJanuary 28 to January 31$58
ATLSt. LouisMarch 31 to April 7$59
TPASt. LouisJanuary 19 to January 19$79
JFKSt. LouisJanuary 31 to February 7$128
DFWSt. LouisJanuary 28 to January 31$129
DFWScott CityJanuary 9 to January 18$139
LGASt. LouisFebruary 7 to February 9$147
LAXSt. LouisJanuary 24 to January 31$148
SEASt. LouisMarch 10 to March 18$159
DENScott CityFebruary 18 to February 23$338
DENWest PaducahFebruary 15 to February 18$397
SEAScott CityJanuary 29 to February 2$416
PHLScott CityJanuary 11 to January 18$540
FCOSt. LouisMarch 13 to March 21$749
TPAScott CityMarch 13 to March 22$6,081
*Prices include taxes and fees
OriginDestinationTravel DatesFlights From*
DENSt. LouisJanuary 10 to January 24$112
DFWScott CityJanuary 9 to January 18$139
ATLSt. LouisJanuary 11 to January 14$142
PHLSt. LouisJanuary 9 to January 12$199
LAXSt. LouisJanuary 11 to January 17$219
LGASt. LouisJanuary 9 to January 11$235
LGASt. LouisJanuary 9 to January 11$235
TPASt. LouisJanuary 9 to January 19$252
DFWSt. LouisJanuary 9 to January 11$277
SEASt. LouisJanuary 9 to January 11$328
PHLScott CityJanuary 11 to January 18$540
*Prices include taxes and fees

Sikeston Flight Information

Traveling to
Sikeston
Lowest Price
$58
Number of Airlines Serving
Airlines Serving
Frontier Airlines
Number of Daily Flights
Airlines with Direct Flights

Find The Perfect Hotel For After Your Flight

Amazing Sikeston Accommodation Deals

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue Sikeston MO
$75 nightly
The price is $86 total per night from Jan 6 to Jan 7
$86 total
Jan 6 - Jan 7
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,005 reviews)
Very clean, very friendly! We will be staying again.

Reviewed on Dec 28, 2025

Opens in a new windowPear Tree Inn Sikeston
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
$70 nightly
The price is $79 total per night from Jan 7 to Jan 8
$79 total
Jan 7 - Jan 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,001 reviews)
Breakfast great hot and big variety

Reviewed on Dec 20, 2025

Opens in a new windowPear Tree Inn Cape Girardeau West
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
$63 nightly
The price is $72 total per night from Jan 4 to Jan 5
$72 total
Jan 4 - Jan 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,002 reviews)
Staff was very nice. Room layout with two separate rooms was appreciated, especially at this price point. Good bed and bedding. Not super high end or careful about the rehab, and the breakfast was a carb fest, but overall we still felt it was a very good value

Reviewed on Dec 26, 2025

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
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Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street Cape Girardeau MO
$91 nightly
The price is $103 total per night from Jan 11 to Jan 12
$103 total
Jan 11 - Jan 12
Total with taxes and fees
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,000 reviews)
It was amazing check in to check out

Reviewed on Dec 14, 2025

Opens in a new windowHoliday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
$63 nightly
The price is $72 total per night from Jan 4 to Jan 5
$72 total
Jan 4 - Jan 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,002 reviews)
Staff was very nice. Room layout with two separate rooms was appreciated, especially at this price point. Good bed and bedding. Not super high end or careful about the rehab, and the breakfast was a carb fest, but overall we still felt it was a very good value

Reviewed on Dec 26, 2025

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, a water park, and laundry facilities. Popular attractions Riverfront Park and eDen Spa & Salon are ...
9.8/10 Exceptional! (172 reviews)
Great location, quality bedding and pillows, and other comfortable amenities for a short getaway in historic downtown Cape Girardeau. Excellent value!

Reviewed on Dec 15, 2025

Get rates
Opens in a new windowHistorical 'Kage House' Short Term Rental located in "Old Town Cape"
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5
3248 William St Cape Girardeau MO
$70 nightly
The price is $79 total per night from Jan 7 to Jan 8
$79 total
Jan 7 - Jan 8
Total with taxes and fees
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,002 reviews)
Everything was wonderful. Staff (especially Debbie) was the best. This is a nice quiet comfortable pplace to stay

Reviewed on Dec 26, 2025

Opens in a new windowPear Tree Inn Cape Girardeau Near the Medical Center
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Quality Inn

Quality Inn

2.5 out of 5
2011 North Kingshighway Cape Girardeau MO
$59 nightly
The price is $67 total per night from Jan 8 to Jan 9
$67 total
Jan 8 - Jan 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
7/10 Good! (686 reviews)
Comfortable bed

Reviewed on Dec 16, 2025

Opens in a new windowQuality Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$90 nightly
The price is $103 total per night from Jan 6 to Jan 7
$103 total
Jan 6 - Jan 7
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,003 reviews)
Everything was great

Reviewed on Dec 29, 2025

Opens in a new windowDrury Inn & Suites Sikeston, MO
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue Sikeston MO
$75 nightly
The price is $86 total per night from Jan 6 to Jan 7
$86 total
Jan 6 - Jan 7
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,005 reviews)
Very clean, very friendly! We will be staying again.

Reviewed on Dec 28, 2025

Opens in a new windowPear Tree Inn Sikeston
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive Sikeston MO
$77 nightly
The price is $88 total per night from Jan 6 to Jan 7
$88 total
Jan 6 - Jan 7
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,000 reviews)
Great place to stay to stop over for the night. Very clean. Great value.

Reviewed on Dec 25, 2025

Opens in a new windowBest Western Plus Sikeston
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Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
$90 nightly
The price is $102 total per night from Jan 7 to Jan 8
$102 total
Jan 7 - Jan 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (999 reviews)
Clean and very nice room

Reviewed on Dec 24, 2025

Opens in a new windowDrury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Economy Special

  • 4 people
  • Unlimited mileage
St Louis, Missouri, USA

$31

$80 total
found 3 days ago
Economy Special undefined

Compact

  • 5 people
  • Unlimited mileage
St Louis, Missouri, USA

$34

$88 total
found 3 days ago
Compact undefined

Midsize

  • 5 people
  • Unlimited mileage
St Louis, Missouri, USA

$35

$90 total
found 3 days ago
Midsize undefined

Fullsize

  • 5 people
  • Unlimited mileage
St Louis, Missouri, USA

$38

$98 total
found 3 days ago
Fullsize undefined
Lowest prices found within the past 3 days. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Which airlines fly to Sikeston?
You won't find many airlines that service Sikeston. So, if you're planning to embark on your long-anticipated adventure from here, book a seat with Cape Air as soon as you can.
Where to stay in Sikeston
Lock in your Sikeston accommodations through Travelocity and then turn your attention to what really matters — creating remarkable travel memories. Pick from 12 lodgings from which you can explore this enticing destination.If you're on the hunt for the top accommodation options in Sikeston, we suggest the Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel and the Hampton Inn Sikeston. Reserve a room and then start booking all your exciting getaway activities.
Places to visit in Sikeston
Every visitor will hear talk of The Book Bug at least once. It's a well-known local store. Like some more ideas? Lovers of painting should plan to pay a visit to Sikeston Depot Museum where they'll certainly be impressed. But that's not all there is. Central Park is an urban sanctuary. It is a beautiful place to go for a jog and enjoy the outdoors.
How to get through airport security fast when traveling to Sikeston
Your adventure to Sikeston starts as soon as you've finished all the security checks. Here are some tips and pointers to help you get through quickly:

  • Security personnel will ask to see your travel ID and boarding pass as part of their checks. Tuck them away in a convenient place, so they're all ready for inspection.
  • Remove your shoes and belt before arriving at the airport security checkpoint. Items like these are not permitted to pass through the body scanner.
  • Make sure your phone, laptop and other electronic devices are easily accessible. These items need to be sent through the X-ray machine separately.
  • When you approach the security checkpoint, you'll be asked to place all creams, gels and liquids in a separate tray for scanning. Make sure they're all packed in containers smaller than 3.4 ounces (100 milliliters) and sealed in a clear zip-lock bag.
  • Security personnel will likely tell you to take off your shoes for the body scanner. Choose a pair that you can slip off easily. There's nothing more irritating than having to do your laces up over and over again.
  • Pocketknives and corkscrews are not permitted on board the aircraft. Tuck them away in your checked luggage to avoid them being confiscated at the airport security checkpoint.

Plane Tickets To Sikeston

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Sikeston. Browse through our inventory to explore a wide range of cheap flights to Sikeston to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Sikeston as you anxiously await to exit the plane and explore what Sikeston has to offer. Considering all the amazing local food and culture in Sikeston, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Sikeston to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Sikeston without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Sikeston with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Sikeston today!

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*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.