Southeast Missouri Vacation Packages 2025/2026 from $443

Southeast Missouri flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

$443

per person

Nov 6 - Nov 8

found 1 day ago

Roundtrip flight included

Washington (DCA) to St. Louis (STL)

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Comfort Suites Rolla

$526

per person

Sep 24 - Sep 29

found 1 day ago

Roundtrip non-stop flight included

Washington (WAS) to St. Louis (STL)

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.

Ameristar Casino Resort and Spa

$510

per person

Nov 6 - Nov 8

found 1 day ago

Roundtrip flight included

Washington (DCA) to St. Louis (STL)

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside bar.

Hermann Grain Bins BNB

Save 100% on your flight

$1,381

per person

Sep 24 - Sep 29

found 1 day ago

Roundtrip non-stop flight included

Washington (WAS) to St. Louis (STL)

This bed & breakfast features free WiFi in public areas, barbecue grills, and free self parking. Enjoy the free full breakfast each morning. A garden and a picnic area are also provided.

Hampton Inn & Suites St. Charles Old Town Area

$462

per person

Oct 10 - Oct 13

found 11 hours ago

Roundtrip flight included

Las Vegas (LAS) to St. Louis (STL)

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.

Top Southeast Missouri hotels deals

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St, Farmington, MO

Free Cancellation

Reserve now, pay when you stay

$55 nightly

$63 total

Sep 1 - Sep 2

Total includes taxes and fees

This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.

Pool

Breakfast included

The Riverview

777 Main St, Cape Girardeau, MO

Free Cancellation

Reserve now, pay when you stay

$117 nightly

$132 total

Aug 21 - Aug 22

Total includes taxes and fees

This hotel features a casino and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. Relax with a drink at one of the 2 bars/lounges and enjoy perks like free self parking.

Parking included

Free WiFi

The Farmstead Hotel

778 E 3rd St, Caruthersville, MO

Free Cancellation

Reserve now, pay when you stay

$132 nightly

$154 total

Sep 10 - Sep 11

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock assistance.

Parking included

Free WiFi

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive, Cape Girardeau, MO

Free Cancellation

Reserve now, pay when you stay

$90 nightly

$102 total

Aug 24 - Aug 25

Total includes taxes and fees

This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Pool

Hot Tub

Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO

Free Cancellation

Reserve now, pay when you stay

$79 nightly

$83 total

Aug 24 - Aug 25

Total includes taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed around-the-clock.

Pet friendly

Parking included

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy, Cape Girardeau, MO

Free Cancellation

Reserve now, pay when you stay

$70 nightly

$79 total

Aug 21 - Aug 22

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour business center. A gym and a safe deposit box are also provided.

Breakfast included

Pet friendly

Don't see what you're looking for?

See all available properties in Southeast Missouri

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Taum Sauk Mountain in located in the St.Francis mountain range of south/central Missouri. It's also the highest point in Missouri. My kids are standing at the spot where the actual marker sign in

Elephant Rocks State Park

5/5(13 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Echo Bluff is Missouri's newest State Park.

Echo Bluff State Park

4.5/5(8 reviews)

You can take time to visit Echo Bluff State Park during your travels to Salem. While you're in the area, stroll along the riverfront.

Beautiful area. Easy to get up close and not too far off the main road. 🏞 #waterfalls #nature #explore #missouri

Rocky Falls

4.5/5(2 reviews)

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Frequently asked questions

How much are vacation packages to Southeast Missouri?

Packages, which include flights and hotels in Southeast Missouri, start at just $443. Make your travel dreams a reality and book your dream trip with Travelocity today.

Where can I get the best vacation package deals for Southeast Missouri?

There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you're ready to cross another place off your travel bucket list.

Why should I book my Southeast Missouri vacation package via Travelocity?

From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you're being taken care of before, during and after your trip. And don't panic if you notice a lower price on your booking, we'll match it. That's our Price Match Guarantee.

Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?

Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.

Which airport is best for Southeast Missouri?

Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.

What is there to do in Southeast Missouri?

Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson's Shut-ins State Park and Meramec Caverns while you're here. These landmarks shouldn't be missed.