Southeast Missouri Vacation Packages 2026 from $328

Southeast Missouri flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

White House at Grand Central

Grand Center

$328

per person

Apr 1 - Apr 4

found 24 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

This apartment features a garden, express check-out, and laundry facilities. The front desk is staffed around-the-clock and barbecue grills are on offer.

The Wildwood Hotel

Save 100% on your flight

$356

per person

Apr 1 - Apr 4

found 24 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Hermann Grain Bins BNB

Save 100% on your flight

$1,465

per person

Mar 2 - Mar 8

found 14 hours ago

Roundtrip non-stop flight included

New York (JFK) to St. Louis (STL)

This bed & breakfast features free WiFi in public areas, barbecue grills, and free self parking. Enjoy the free full breakfast each morning. A garden and a picnic area are also provided.

The Cheshire

$434

per person

Apr 1 - Apr 4

found 24 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal outdoor pool and free English breakfast each morning.

21C Museum Hotel St Louis

Downtown West

$352

per person

Apr 1 - Apr 4

found 24 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Enjoy the gym and conveniences like a 24-hour front desk and concierge services.

Top Southeast Missouri hotels deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Free Cancellation

Reserve now, pay when you stay

$90 nightly

$102 total

Feb 1 - Feb 2

Total with taxes and fees

This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Pool

Hot Tub

The Riverview

777 Main St Cape Girardeau MO

Free Cancellation

Reserve now, pay when you stay

$96 nightly

$109 total

Jan 28 - Jan 29

Total with taxes and fees

This hotel features a casino and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. Relax with a drink at one of the 2 bars/lounges and enjoy perks like free self parking.

Parking included

Free WiFi

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Free Cancellation

Reserve now, pay when you stay

$54 nightly

$62 total

Jan 28 - Jan 29

Total with taxes and fees

This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.

Pool

Breakfast included

The Farmstead Hotel

778 E 3rd St Caruthersville MO

Free Cancellation

Reserve now, pay when you stay

$76 nightly

$86 total

Jan 23 - Jan 24

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock assistance.

Parking included

Free WiFi

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$90 nightly

$103 total

Jan 26 - Jan 27

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Pool

Breakfast included

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

Free Cancellation

Reserve now, pay when you stay

$57 nightly

$60 total

Jan 25 - Jan 26

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed around-the-clock.

Pet friendly

Parking included

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

An old granite quarry that has filled with water. An beautiful spring hike around the lake got me this picture

Elephant Rocks State Park

5/5(13 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Lake Wappapello

4/5(18 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Isle Casino Cape Girardeau

4.5/5(48 reviews)

Why not roll the dice with a visit to Isle Casino Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

Frequently asked questions

How much are vacation packages to Southeast Missouri?

Packages, which include flights and hotels in Southeast Missouri, start at just $328. Make your travel dreams a reality and book your dream trip with Travelocity today.

Where can I get the best vacation package deals for Southeast Missouri?

There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you're ready to cross another place off your travel bucket list.

Why should I book my Southeast Missouri vacation package via Travelocity?

From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you're being taken care of before, during and after your trip. And don't panic if you notice a lower price on your booking, we'll match it. That's our Price Match Guarantee.

Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?

Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.

Which airport is best for Southeast Missouri?

Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.

What is there to do in Southeast Missouri?

Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson's Shut-ins State Park and Meramec Caverns while you're here. These landmarks shouldn't be missed.