
Deals on vacations and trips to Southeast Missouri
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Southeast Missouri flight + hotel vacation packages
Price found within the past 48 hours. Click for updated prices.

Hilton Garden Inn Chesterfield
Save 100% on your flight
per person
Aug 11 - Aug 16
found 1 day ago
Roundtrip flight included
Cleveland (CLE) to St. Louis (STL)
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the 24-hour gym and perks like free self parking.

The Wildwood Hotel
Save 100% on your flight
per person
Aug 11 - Aug 16
found 1 day ago
Roundtrip flight included
Cleveland (CLE) to St. Louis (STL)
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Moonrise Hotel
Delmar Loop
Save 100% on your flight
per person
Aug 11 - Aug 16
found 1 day ago
Roundtrip flight included
Cleveland (CLE) to St. Louis (STL)
The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. Enjoy a meal from the a restaurant and perks like free self parking.

Ameristar Casino Resort and Spa
Save 100% on your flight
per person
Aug 11 - Aug 16
found 1 day ago
Roundtrip flight included
Cleveland (CLE) to St. Louis (STL)
This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside bar.

The Cheshire
Save 100% on your flight
per person
Aug 11 - Aug 16
found 1 day ago
Roundtrip flight included
Cleveland (CLE) to St. Louis (STL)
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal outdoor pool and free English breakfast each morning.
Top Southeast Missouri hotels deals

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
Free Cancellation
Reserve now, pay when you stay
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included

The Riverview
777 Main St, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
This hotel features a casino and 2 restaurants. Relax with a drink at one of the 2 bars/lounges and enjoy free perks like free self parking and WiFi in public areas. A coffee shop is provided and the front desk is staffed around-the-clock.
Parking included
Free WiFi

Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
Pool
Hot Tub

Motel 6 Poplar Bluff, MO
4101 Highway 67 N, Poplar Bluff, MO
Free Cancellation
Reserve now, pay when you stay
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed around-the-clock.
Pet friendly
Parking included

Fairfield Inn & Suites by Marriott Poplar Bluff
3109 Oak Grove, Poplar Bluff, MO
Free Cancellation
Reserve now, pay when you stay
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.
Pool
Breakfast included

Best Western Plus Sikeston
120 S Interstate Drive, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour business center, a grocery/convenience store, and express check-out are also on offer.
Pool
Breakfast included
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See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit

Echo Bluff State Park
4.5/5(8 reviews)
You can take time to visit Echo Bluff State Park during your travels to Salem. While you're in the area, stroll along the riverfront.

Elephant Rocks State Park
5/5(13 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Lake Wappapello
4/5(18 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
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