Southeast Missouri Vacation Packages 2025/2026 from $446

Southeast Missouri flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Lodge Of Four Seasons Golf Resort, Marina & Spa

per person

Aug 27 - Aug 31

found 21 hours ago

Roundtrip flight included

Tampa (TPA) to St. Louis (STL)

This resort features a golf course, a full-service spa, and a marina. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. You'll find 2 restaurants and 5 bars/lounges for dining and drinks, and an indoor pool is also on site.

The Wildwood Hotel

Save 100% on your flight

per person

Aug 9 - Aug 13

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Camden on the Lake Resort & Spa

Save 100% on your flight

per person

Aug 27 - Aug 31

found 21 hours ago

Roundtrip flight included

Tampa (TPA) to St. Louis (STL)

This smoke-free resort features a full-service spa, a nightclub, and a marina. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free self parking is free for guests, and you can enjoy a meal in one of the 2 restaurants.

Ballpark Apartments by Barsala

Downtown St. Louis

per person

Aug 9 - Aug 13

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

A gym is featured at this aparthotel, along with free WiFi in public areas and barbecue grills. A virtual front desk are provided for your convenience.

Ameristar Casino Resort and Spa

per person

Aug 9 - Aug 13

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside bar.

Top Southeast Missouri hotels deals

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St, Farmington, MO

Free Cancellation

Reserve now, pay when you stay

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This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.

Pool

Breakfast included

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive, Cape Girardeau, MO

Free Cancellation

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This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Pool

Hot Tub

The Riverview

777 Main St, Cape Girardeau, MO

Free Cancellation

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This hotel features a casino and 2 restaurants. Relax with a drink at one of the 2 bars/lounges and enjoy free perks like free self parking and WiFi in public areas. A coffee shop is provided and the front desk is staffed around-the-clock.

Parking included

Free WiFi

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3003 SOUTH OLD ORCHARD ROAD, Jackson, MO

Free Cancellation

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This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like self-serve breakfast and free self parking.

Pool

Breakfast included

Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO

Free Cancellation

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This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed around-the-clock.

Pet friendly

Parking included

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street, Cape Girardeau, MO

Free Cancellation

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A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and perks like free self parking.

Pool

Breakfast included

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Echo Bluff is Missouri's newest State Park.

Echo Bluff State Park

4.5/5(8 reviews)

You can take time to visit Echo Bluff State Park during your travels to Salem. While you're in the area, stroll along the riverfront.

Taum Sauk Mountain in located in the St.Francis mountain range of south/central Missouri. It's also the highest point in Missouri. My kids are standing at the spot where the actual marker sign in

Elephant Rocks State Park

5/5(13 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Breathtaking view at the dam by the road and some small trails for walking as well!

Lake Wappapello

4/5(18 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Frequently asked questions

How much are vacation packages to Southeast Missouri?

Packages, which include flights and hotels in Southeast Missouri, start at just $446. Make your travel dreams a reality and book your dream trip with Travelocity today.

Where can I get the best vacation package deals for Southeast Missouri?

There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you're ready to cross another place off your travel bucket list.

Why should I book my Southeast Missouri vacation package via Travelocity?

From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you're being taken care of before, during and after your trip. And don't panic if you notice a lower price on your booking, we'll match it. That's our Price Match Guarantee.

Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?

Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.

Which airport is best for Southeast Missouri?

Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.

What is there to do in Southeast Missouri?

Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson's Shut-ins State Park and Meramec Caverns while you're here. These landmarks shouldn't be missed.