Deals on vacations and trips to Southeast Missouri

Save when you book Southeast Missouri package deals

Choose two or more items and save on your trip:

Southeast Missouri flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.
Fairfield Inn by Marriott St. Louis Collinsville, IL

Fairfield Inn by Marriott St. Louis Collinsville, IL

3 out of 5
Eastport
Price was $613, price is now $516 per person
$516
per person
Aug 20 - Aug 23
found 1 day ago
Roundtrip non-stop flight included
Portland (PDX) to St. Louis (STL)
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour business center. There's a 24-hour gym on site, and a 24-hour front desk and express check-out are also provided.
The Cheshire

The Cheshire

4 out of 5
Price was $787, price is now $643 per person
$643
per person
Aug 20 - Aug 23
found 1 day ago
Roundtrip non-stop flight included
Portland (PDX) to St. Louis (STL)
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal outdoor pool and free English breakfast each morning.
Moonrise Hotel

Moonrise Hotel

4 out of 5
Delmar Loop
Price was $725, price is now $608 per person
$608
per person
Aug 20 - Aug 23
found 1 day ago
Roundtrip non-stop flight included
Portland (PDX) to St. Louis (STL)
The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy a meal from the a restaurant and perks like free self parking.
Landing Amazing 1bd, Yoga Studio, Gym

Landing Amazing 1bd, Yoga Studio, Gym

3 out of 5
DeBaliviere Place
Price was $875, price is now $734 per person
$734
per person
Sep 11 - Sep 13
found 1 day ago
Roundtrip flight included
Portland (PDX) to St. Louis (STL)
This apartment features a gym and a seasonal outdoor pool. WiFi in public areas is free. Self parking and a virtual front desk are also offered on site.
The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
Central West End
Price was $841, price is now $718 per person
$718
per person
Sep 11 - Sep 13
found 1 day ago
Roundtrip flight included
Portland (PDX) to St. Louis (STL)
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. You'll appreciate the seasonal outdoor pool, poolside bar, and concierge services.

Top Southeast Missouri hotels deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$100 nightly
The price is $113 total per night
$113 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
Pool
Hot Tub
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Free Cancellation
Reserve now, pay when you stay
$59 nightly
The price is $64 total per night
$64 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$111 nightly
The price is $128 total per night
$128 total
Jul 9 - Jul 10
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
Pool
Breakfast included
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$69 nightly
The price is $78 total per night
$78 total
Jul 26 - Jul 27
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 3 onsite conference rooms. Enjoy the gym and conveniences like a 24-hour front desk and laundry facilities.
Breakfast included
Pet friendly
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$121 nightly
The price is $136 total per night
$136 total
Aug 3 - Aug 4
Total with taxes and fees
This hotel features a casino and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. Relax with a drink at one of the 2 bars/lounges and enjoy perks like free self parking.
Parking included
Free WiFi
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
Free Cancellation
Reserve now, pay when you stay
$84 nightly
The price is $96 total per night
$96 total
Jul 6 - Jul 7
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business center. There's a gym on site, and a 24-hour front desk and a convenience store are also provided.
Breakfast included
Pet friendly
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties

Frequently asked questions

How much are vacation packages to Southeast Missouri?
Packages, which include flights and hotels in Southeast Missouri, start at just $516. Make your travel dreams a reality and book your dream trip with Travelocity today.
Where can I get the best vacation package deals for Southeast Missouri?
There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you're ready to cross another place off your travel bucket list.
Why should I book my Southeast Missouri vacation package via Travelocity?
From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you're being taken care of before, during and after your trip. And don't panic if you notice a lower price on your booking, we'll match it. That's our Price Match Guarantee.
Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?
Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.
Which airport is best for Southeast Missouri?
Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.
What is there to do in Southeast Missouri?
Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson's Shut-ins State Park and Meramec Caverns while you're here. These landmarks shouldn't be missed.

Photos of local treasures

Browse Southeast Missouri vacation photos for more inspiration

A group of men in red uniforms with gold accents, holding rifles and wearing kilts.
A river flowing through a rocky landscape with dense green forest in the background.
A rocky river with clear water flowing over rocks.
A rocky shoreline with a calm lake and distant islands.
A river running through a forested landscape with a dirt road parallel to the river.

Explore More Ways to Travel with Travelocity