Southeast Missouri Vacation Packages 2025 from $502

Southeast Missouri flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

HoteLumiere at the Arch

Downtown St. Louis

Save 100% on your flight

per person

Jun 25 - Jun 29

found 21 hours ago

Roundtrip non-stop flight included

Atlanta (ATL) to St. Louis (STL)

This hotel features a casino and 3 restaurants. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. A coffee shop, express check-out, and luggage storage are also on offer.

White House at Grand Central

Grand Center

per person

Jul 10 - Jul 14

found 1 day ago

Roundtrip non-stop flight included

Sacramento (SMF) to St. Louis (STL)

This apartment features a garden, express check-out, and laundry facilities. Barbecue grills are provided for your convenience.

Spacious 3-Bedroom with King Bed

Central West End

Save 100% on your flight

per person

Jun 25 - Jun 29

found 21 hours ago

Roundtrip non-stop flight included

Atlanta (ATL) to St. Louis (STL)

This apartment doesn't skimp on freebies - guests receive free WiFi and free self parking. A garden, laundry facilities, and a virtual front desk are also on offer.

Elimwood Hotel, A Ramada by Wyndham

per person

Jul 10 - Jul 14

found 1 day ago

Roundtrip non-stop flight included

Sacramento (SMF) to St. Louis (STL)

This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and airport shuttle. Guests will appreciate freebies like continental breakfast and free self parking.

Best Western St. Louis-Kirkwood Route 66

per person

Jun 12 - Jun 18

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal outdoor pool and free perks like full breakfast and free self parking.

Top Southeast Missouri hotels deals

The Riverview

777 Main St, Cape Girardeau, MO

Free Cancellation

Reserve now, pay when you stay

$121

includes taxes & fees

$107 per night

May 12 - May 13

This hotel features a casino and 2 restaurants. Relax with a drink at one of the 2 bars/lounges and enjoy free perks like free self parking and WiFi in public areas. A coffee shop is provided and the front desk is staffed around-the-clock.

Parking included

Free WiFi

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St, Farmington, MO

Free Cancellation

Reserve now, pay when you stay

$64

includes taxes & fees

$56 per night

May 11 - May 12

This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.

Pool

Breakfast included

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive, Cape Girardeau, MO

Free Cancellation

Reserve now, pay when you stay

$102

includes taxes & fees

$90 per night

May 12 - May 13

This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Pool

Hot Tub

Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO

Free Cancellation

Reserve now, pay when you stay

$83

includes taxes & fees

$79 per night

May 8 - May 9

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed around-the-clock.

Pet friendly

Parking included

Pear Tree Inn Sikeston

2602 E Malone Avenue, Sikeston, MO

Free Cancellation

Reserve now, pay when you stay

$98

includes taxes & fees

$85 per night

May 11 - May 12

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free daily breakfast.

Pool

Hot Tub

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3003 SOUTH OLD ORCHARD ROAD, Jackson, MO

Free Cancellation

Reserve now, pay when you stay

$93

includes taxes & fees

$86 per night

Jun 1 - Jun 2

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like self-serve breakfast and free self parking.

Pool

Breakfast included

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Taum Sauk Mountain in located in the St.Francis mountain range of south/central Missouri. It's also the highest point in Missouri. My kids are standing at the spot where the actual marker sign in

Elephant Rocks State Park

5/5(13 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Echo Bluff is Missouri's newest State Park.

Echo Bluff State Park

4.5/5(8 reviews)

You can take time to visit Echo Bluff State Park during your travels to Salem. While you're in the area, stroll along the riverfront.

Breathtaking view at the dam by the road and some small trails for walking as well!

Lake Wappapello

4/5(18 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Frequently asked questions

How much are vacation packages to Southeast Missouri?

Packages, which include flights and hotels in Southeast Missouri, start at just $502. Make your travel dreams a reality and book your dream trip with Travelocity today.

Where can I get the best vacation package deals for Southeast Missouri?

There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you’re ready to cross another place off your travel bucket list.

Why should I book my Southeast Missouri vacation package via Travelocity?

From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you’re being taken care of before, during and after your trip. And don’t panic if you notice a lower price on your booking, we’ll match it. That’s our Price Match Guarantee.

Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?

Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.

Which airport is best for Southeast Missouri?

Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.

What is there to do in Southeast Missouri?

Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson’s Shut-ins State Park and Meramec Caverns while you’re here. These landmarks shouldn’t be missed.