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Deals on vacations and trips to Southeast Missouri
Save when you book Southeast Missouri package deals
Southeast Missouri flight + hotel vacation packages
Price found within the past 48 hours. Click for updated prices.
![Crowne Plaza St. Louis Airport, an IHG Hotel](https://images.trvl-media.com/lodging/1000000/10000/3100/3010/db9ce393_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)
Crowne Plaza St. Louis Airport, an IHG Hotel
per person
Aug 2 - Aug 5
found 1 day ago
Roundtrip flight included
Houston (IAH) to St. Louis (STL)
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport shuttle. Enjoy the gym and perks like a free area shuttle.
![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/4059f405_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)
The Wildwood Hotel
Save 100% on your flight
per person
Aug 2 - Aug 5
found 1 day ago
Roundtrip flight included
Houston (IAH) to St. Louis (STL)
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the spa tub and free perks like continental breakfast and free self parking.
![The Cheshire](https://images.trvl-media.com/lodging/1000000/30000/26100/26061/0d84abdd_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)
The Cheshire
per person
Aug 2 - Aug 5
found 1 day ago
Roundtrip flight included
Houston (IAH) to St. Louis (STL)
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal outdoor pool and free English breakfast each morning.
![The Charles F. Knight Center](https://images.trvl-media.com/lodging/39000000/38720000/38711900/38711810/4865eb6e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)
![Hollywood Casino & Hotel St. Louis](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/7188325f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)
Hollywood Casino & Hotel St. Louis
per person
Aug 2 - Aug 5
found 1 day ago
Roundtrip flight included
Houston (IAH) to St. Louis (STL)
A casino, 7 restaurants, and a 24-hour gym are all featured at this hotel. Traveling for business? Take advantage of the 24-hour business center, express check-out, and conference space. Relax with a drink at one of the 3 bars/lounges and enjoy perks like free self parking.
Top Southeast Missouri hotels deals
![Auburn Place Hotel And Suites](https://images.trvl-media.com/lodging/1000000/980000/980000/979972/ee364310_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Auburn Place Hotel And Suites
3265 William St, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
The price is $66 per night
$66
per night
Jul 18 - Jul 19
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the free buffet breakfast each morning.
Pool
Breakfast included
![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/f23ff087_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
The price is $69 per night
$69
per night
Jun 19 - Jun 20
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 3 onsite conference rooms. Enjoy the gym and conveniences like a 24-hour front desk and laundry facilities.
Breakfast included
Pet friendly
![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/6388963b_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Motel 6 Poplar Bluff, MO
4101 Highway 67 N, Poplar Bluff, MO
The price is $77 per night
$77
per night
Jun 30 - Jul 1
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed around-the-clock.
Pet friendly
Parking included
![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/fd7e3411_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
Free Cancellation
Reserve now, pay when you stay
The price is $56 per night
$56
per night
Jul 15 - Jul 16
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included
![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/eb9ae498_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
The price is $64 per night
$64
per night
Jun 23 - Jun 24
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour business center. A gym and a safe deposit box are also provided.
Breakfast included
Pet friendly
![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Sikeston, MO
The price is $94 per night
$94
per night
Jul 7 - Jul 8
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
Pool
Breakfast included
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Meramec Caverns
5/5(21 reviews)
Explore the great outdoors at Meramec Caverns, a lovely green space in Sullivan. While in this family-friendly area, you can enjoy the coffeehouses.
Elephant Rocks State Park
5/5(13 reviews)
Explore the great outdoors at Elephant Rocks State Park, a lovely green space in Ironton. Make some time to visit the shops while you're in the area.
Ohio River
Commune with nature and explore the great outdoors at Ohio River during your travels in Valley Station. While you're in the area, wander around the parks.
Photos of local treasures
Browse Southeast Missouri vacation photos for more inspiration
![Southeast Missouri](https://mediaim.expedia.com/destination/9/6538ce9b088c58039b33a5fe701e7a1f.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)
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