Cheap Flights to Southeast Missouri from $20

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How Much Does it Cost To Fly To Southeast Missouri?

The cheapest prices found with in the last 7 days for return flights were $56 and $20 for one-way flights to Southeast Missouri for the period specified. Prices and availability are subject to change. Additional terms apply

Fri, Nov 13 - Wed, Nov 18
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$56 Roundtrip, found 1 day ago
$56
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Fri, Nov 13 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Nov 18, priced at $56 found 1 day ago
OriginDestinationTravel DatesFlights From*
MCISt. LouisOctober 28 to November 2$117
MSPSt. LouisOctober 29 to November 5$117
BWISt. LouisNovember 4 to November 11$143
EWRSt. LouisNovember 11 to November 12$175
DCASt. LouisNovember 18 to November 21$201
LAXSt. LouisNovember 18 to November 23$204
CMHSt. LouisDecember 23 to December 29$212
MSYSt. LouisNovember 25 to November 29$270
LAXWest PaducahOctober 24 to October 31$373
MCIMarionOctober 14 to October 21$504
DCAMarionOctober 14 to October 21$598
BWIScott CityOctober 13 to October 20$629
BWIMarionOctober 14 to October 21$630
LAXScott CityOctober 31 to November 7$959
DCAScott CityDecember 17 to December 24$1,197
*Prices include taxes and fees
OriginDestinationTravel DatesFlights From*
BWISt. LouisOctober 4 to October 9$389
EWRSt. LouisOctober 4 to October 9$393
LAXSt. LouisOctober 3 to October 10$436
DCASt. LouisOctober 4 to October 5$489
MCISt. LouisOctober 3 to October 5$1,252
CMHSt. LouisOctober 4 to October 7$1,414
SATSt. LouisOctober 3 to October 5$1,459
*Prices include taxes and fees

Southeast Missouri Flight Information

Traveling to
Southeast Missouri
Lowest Price
$56
Number of Airlines Serving
Airlines Serving
Frontier Airlines
Number of Daily Flights
Airlines with Direct Flights

Find The Perfect Hotel For After Your Flight

Amazing Southeast Missouri Accommodation Deals

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
$79 nightly
The price is $88 total per night from Oct 2 to Oct 3
$88 total
Oct 2 - Oct 3
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Opens in a new windowMotel 6 Poplar Bluff, MO
Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington

2 out of 5
930 Valley Creek Dr Farmington MO
$60 nightly
The price is $65 total per night from Oct 11 to Oct 12
$65 total
Oct 11 - Oct 12
Total with taxes and fees
Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (681 reviews)
"Clean room and property + the staff was all very sweet and helpful. The bed was unfortunately pretty uncomfortable."

Reviewed on Sep 29, 2026

Opens in a new windowSuper 8 by Wyndham Farmington
Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2 out of 5
1711 Highway Z Pevely MO
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
Get rates
Opens in a new windowSuper 8 by Wyndham Pevely
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Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
$72 nightly
The price is $81 total per night from Oct 11 to Oct 12
$81 total
Oct 11 - Oct 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Opens in a new windowPear Tree Inn Cape Girardeau West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Southeast Missouri

Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2 out of 5
1711 Highway Z Pevely MO
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
Get rates
Opens in a new windowSuper 8 by Wyndham Pevely
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
$79 nightly
The price is $88 total per night from Oct 2 to Oct 3
$88 total
Oct 2 - Oct 3
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Opens in a new windowMotel 6 Poplar Bluff, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
$66 nightly
The price is $76 total per night from Nov 1 to Nov 2
$76 total
Nov 1 - Nov 2
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Opens in a new windowDays Inn and Suites by Wyndham Sikeston
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Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Riverfront Park and eDen Spa & Salon are located ...
10/10 Exceptional! (228 reviews)
"Very nice hospitality and accommodations ComfortableGreat location"

Reviewed on Jul 5, 2026

Get rates
Opens in a new windowHistorical 'Kage House' Short Term Rental located in "Old Town Cape"
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Southeast Missouri

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$94 nightly
The price is $108 total per night from Oct 29 to Oct 30
$108 total
Oct 29 - Oct 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,001 reviews)
"EVERYONE was EXTREMELY FRIENDLY"

Reviewed on Sep 30, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
$85 nightly
The price is $97 total per night from Nov 1 to Nov 2
$97 total
Nov 1 - Nov 2
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
Opens in a new windowBest Western Plus Sikeston I-55
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
$91 nightly
The price is $103 total per night from Oct 14 to Oct 15
$103 total
Oct 14 - Oct 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,000 reviews)
"Upgraded to a 2 room suite. Rey nice room lots of storage. Would definitely stay here again."

Reviewed on Sep 28, 2026

Opens in a new windowDrury Inn & Suites Cape Girardeau
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Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd Jackson MO
$76 nightly
The price is $82 total per night from Oct 25 to Oct 26
$82 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
Opens in a new windowComfort Suites Jackson-Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best Southeast Missouri Flight and Hotel Packages

Southeast Missouri flight + hotel packages - economy flights

Price found within the past 48 hours. Click for updated prices.
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

2.5 out of 5
Price was $1,248, price is now $1,024 per person
$1,024
per person
Nov 2 - Nov 10
just found
Roundtrip non-stop flight included
Boston (BOS) to St. Louis (STL)
Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

3 out of 5
Price was $1,221, price is now $1,097 per person
$1,097
per person
Nov 25 - Nov 29
found 20 hours ago
Roundtrip non-stop flight included
New York (JFK) to St. Louis (STL)
Holiday Inn Express & Suites St Louis Airport by IHG

Holiday Inn Express & Suites St Louis Airport by IHG

2.5 out of 5
Price was $1,097, price is now $1,038 per person
$1,038
per person
Nov 25 - Nov 29
found 20 hours ago
Roundtrip non-stop flight included
New York (JFK) to St. Louis (STL)
Don't see what you're looking for?
See all available trips from Boston to Southeast Missouri
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Need a Car For After Your Flight?

Mini Van

  • 7 people
  • Unlimited mileage
Saint Louis, Missouri, USA

$67

$207 total
found 1 day ago
Mini Van undefined

Economy

  • 4 people
  • Unlimited mileage
Saint Louis, Missouri, USA

$69

$212 total
found 1 day ago
Economy undefined

Compact

  • 5 people
  • Unlimited mileage
Saint Louis, Missouri, USA

$69

$212 total
found 1 day ago
Compact undefined

Midsize

  • 5 people
  • Unlimited mileage
Saint Louis, Missouri, USA

$70

$215 total
found 1 day ago
Midsize undefined

Frequently asked questions

How much is the cheapest flight to Southeast Missouri?
A roundtrip flight to Southeast Missouri cost as little as $56 over the last seven days. Once you've chosen your travel dates, we'll help you find an amazing deal. This price was available on Travelocity for flights to Southeast Missouri departing within the next year. Prices and availability are subject to change. Additional terms apply.
What is the cheapest month to fly to Southeast Missouri?
Be sure to leave November empty in your calendar, because it's the most affordable month to travel to Southeast Missouri. That's based on Travelocity's direct flight demand from January to December last year. With the cash you save, you can go on a spending spree, go for a fancy dinner or whatever makes you happy.
How can I check my flight status to Southeast Missouri?
Make the most of Travelocity's handy portal, Trips. You'll find just about everything related to your flight to Southeast Missouri here, including details about flight status, gate numbers and more. Look for Trips at the top of the Travelocity homepage. Create your free account and get the answers you need. Or you can access your itinerary while you're on the go and get real-time travel updates through the Travelocity app. You'll find all your itineraries in one place, making it a cinch to share details with any members of your family flying with you.
How do I find the best deals on flights to Southeast Missouri?
Being flexible with your dates is one of the best ways to snag an awesome deal. Travelocity makes it a cinch to find your perfect fare through the "Flexible dates" feature. First, search for your Southeast Missouri flight, then compare prices for surrounding dates by hitting the Flexible dates box above. Booking in advance and avoiding peak travel periods are other steps you can take. In the last seven days, the lowest price for a return flight to Southeast Missouri was $56. This price was available on Travelocity for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
Why should I book my flight to Southeast Missouri with Travelocity?
If you're looking for cheap flights to Southeast Missouri, you'll discover some tempting deals with Travelocity. From cheap family flights with low-cost airlines to flexible tickets, we can help you. Enjoy a worry-free trip with our 24/7 customer support, Price Match Guarantee and free cancellations with most hotels. Start packing your bags and get ready to jump on a plane to this interesting destination.
How much is a flight to Southeast Missouri on average?
Airfares for roundtrip flights to Southeast Missouri were priced between $56 and $1,459 in the last seven days. The minute you spot a good deal, snap it up and get ready for your dream getaway with Travelocity. These prices were available on Travelocity for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
What can I expect on a flight to Southeast Missouri?
Factors like who you're flying with and where you're departing from will mostly determine what you'll be offered on your trip. Chances are you'll find all kinds of flights to Southeast Missouri, from cheap flights for family vacations to premium fares. Warm meals, entertainment and games for the little ones are usually what most airlines offer on long-haul flights.

Plane Tickets To Southeast Missouri

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Southeast Missouri. Browse through our inventory to explore a wide range of cheap flights to Southeast Missouri to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Southeast Missouri as you anxiously await to exit the plane and explore what Southeast Missouri has to offer. Considering all the amazing local food and culture in Southeast Missouri, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Southeast Missouri to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Southeast Missouri without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Southeast Missouri with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Southeast Missouri today!

Explore More Ways to Travel with Travelocity

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.