Cheap Flights to Southeast Missouri from $26

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How Much Does it Cost To Fly To Southeast Missouri?

The cheapest prices found with in the last 7 days for return flights were $60 and $26 for one-way flights to Southeast Missouri for the period specified. Prices and availability are subject to change. Additional terms apply

Fri, Dec 19 - Mon, Jan 5
MCO
Orlando Intl.
STL
Lambert-St. Louis Intl.
$60 Roundtrip, found 3 days ago
$60
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Fri, Dec 19 from Orlando Intl. to Lambert-St. Louis Intl., returning Mon, Jan 5, priced at $60 found 3 days ago
OriginDestinationTravel DatesFlights From*
BWISt. LouisJanuary 8 to January 12$120
MSYSt. LouisDecember 11 to December 15$122
EWRSt. LouisDecember 11 to December 15$138
LAXSt. LouisFebruary 5 to February 9$140
MCISt. LouisJanuary 8 to January 14$140
SATSt. LouisDecember 11 to December 14$155
MSPSt. LouisNovember 20 to November 24$165
DCASt. LouisJanuary 5 to January 21$196
CMHSt. LouisDecember 4 to December 20$200
LAXMarionNovember 18 to November 19$468
LAXWest PaducahDecember 6 to December 13$532
MSPMarionNovember 26 to November 30$583
MCIWest PaducahDecember 27 to December 28$607
DCAScott CityDecember 26 to December 27$668
MSPScott CityDecember 23 to December 27$1,399
*Prices include taxes and fees
OriginDestinationTravel DatesFlights From*
BWISt. LouisNovember 16 to November 20$237
MSYSt. LouisNovember 14 to November 15$265
EWRSt. LouisNovember 14 to November 20$274
LAXSt. LouisNovember 16 to November 17$292
DCASt. LouisNovember 15 to November 24$403
CMHSt. LouisNovember 15 to December 3$410
MCISt. LouisNovember 14 to November 18$467
MSPSt. LouisNovember 15 to November 15$533
LAXMarionNovember 14 to November 17$656
SATSt. LouisNovember 16 to November 20$701
*Prices include taxes and fees

Southeast Missouri Flight Information

Traveling to
Southeast Missouri
Lowest Price
$60
Number of Airlines Serving
Airlines Serving
Frontier Airlines
Number of Daily Flights
Airlines with Direct Flights

Find The Perfect Hotel For After Your Flight

Amazing Southeast Missouri Accommodation Deals

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
$79 nightly
The price is $83 total per night from Nov 9 to Nov 10
$83 total
Nov 9 - Nov 10
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,003 reviews)
Clean room and helpful staff

Reviewed on Oct 29, 2025

Opens in a new windowMotel 6 Poplar Bluff, MO
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
$77 nightly
The price is $89 total per night from Nov 15 to Nov 16
$89 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,003 reviews)
Pool lambert restaurant and others friendly peaceful environment

Reviewed on Nov 3, 2025

Opens in a new windowPear Tree Inn Sikeston
Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington

2 out of 5
930 Valley Creek Dr, Farmington, MO
$51 nightly
The price is $58 total per night from Nov 14 to Nov 15
$58 total
Nov 14 - Nov 15
Total with taxes and fees
Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (599 reviews)
The room was fine and we had a great stay. No elevators and we had to grapple with opening stairwell doors while our hands were full but it was just something to get used to. The staff was great and helpful!

Reviewed on Oct 31, 2025

Opens in a new windowSuper 8 by Wyndham Farmington
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Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2 out of 5
1711 Highway Z, Pevely, MO
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (829 reviews)
Adequate
Hotel is in rough shape…but if you just need a place to sleep for the night it will fulfill that. Hotel needs a major revamping.

Reviewed on May 17, 2025

Get rates
Opens in a new windowSuper 8 by Wyndham Pevely
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Southeast Missouri

Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2 out of 5
1711 Highway Z, Pevely, MO
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (829 reviews)
Adequate
Hotel is in rough shape…but if you just need a place to sleep for the night it will fulfill that. Hotel needs a major revamping.

Reviewed on May 17, 2025

Get rates
Opens in a new windowSuper 8 by Wyndham Pevely
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
$79 nightly
The price is $83 total per night from Nov 9 to Nov 10
$83 total
Nov 9 - Nov 10
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,003 reviews)
Clean room and helpful staff

Reviewed on Oct 29, 2025

Opens in a new windowMotel 6 Poplar Bluff, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr, Sikeston, MO
$63 nightly
The price is $72 total per night from Nov 11 to Nov 12
$72 total
Nov 11 - Nov 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,002 reviews)
Yes

Reviewed on Nov 1, 2025

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
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Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, a water park, and laundry facilities. Popular attractions Riverfront Park and eDen Spa & Salon are ...
9.8/10 Exceptional! (170 reviews)
Great place! It was exactly as advertised. We were so close to shops and restaurants. We will definitely be back!

Reviewed on Oct 12, 2025

Get rates
Opens in a new windowHistorical 'Kage House' Short Term Rental located in "Old Town Cape"
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Southeast Missouri

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
$94 nightly
The price is $108 total per night from Nov 18 to Nov 19
$108 total
Nov 18 - Nov 19
Total with taxes and fees
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,002 reviews)
Clean rooms. Great staff

Reviewed on Nov 5, 2025

Opens in a new windowDrury Inn & Suites Sikeston, MO
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
$77 nightly
The price is $89 total per night from Nov 15 to Nov 16
$89 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,003 reviews)
Pool lambert restaurant and others friendly peaceful environment

Reviewed on Nov 3, 2025

Opens in a new windowPear Tree Inn Sikeston
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive, Sikeston, MO
$84 nightly
The price is $96 total per night from Nov 16 to Nov 17
$96 total
Nov 16 - Nov 17
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,013 reviews)
Good place to stay in Sikestn
All good here

Reviewed on Oct 26, 2025

Opens in a new windowBest Western Plus Sikeston
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Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive, Cape Girardeau, MO
$90 nightly
The price is $102 total per night from Nov 30 to Dec 1
$102 total
Nov 30 - Dec 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,006 reviews)
Rooms are nice and big. Breakfast was above average and staff was very nice and friendly.

Reviewed on Nov 3, 2025

Opens in a new windowDrury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best Southeast Missouri Flight and Hotel Packages

Southeast Missouri flight + hotel packages - economy flights

Price found within the past 48 hours. Click for updated prices.
Crowne Plaza St. Louis Airport by IHG

Crowne Plaza St. Louis Airport by IHG

3.5 out of 5
Price was $419, price is now $344 per person
$344
per person
Dec 30 - Jan 1
found 1 day ago
Roundtrip non-stop flight included
Indianapolis (IND) to St. Louis (STL)
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was $660, price is now $451 per person
$451
per person
Dec 30 - Jan 1
found 1 day ago
Roundtrip non-stop flight included
Indianapolis (IND) to St. Louis (STL)
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Price was $444, price is now $350 per person
$350
per person
Dec 30 - Jan 1
found 1 day ago
Roundtrip non-stop flight included
Indianapolis (IND) to St. Louis (STL)
Don't see what you're looking for?
See all available trips from Indianapolis to Southeast Missouri
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Need a Car For After Your Flight?

Economy

Chevrolet Spark or similar
  • 4 people
Chevrolet Spark
Economy Chevrolet Spark

Compact

Ford Focus or similar
  • 4 people
Ford Focus
Compact Ford Focus

Midsize

Toyota Corolla or similar
  • 5 people
Toyota Corolla
Midsize Toyota Corolla

SUV

Jeep Compass or similar
  • 5 people
Jeep Compass
SUV Jeep Compass

Frequently asked questions

How much is the cheapest flight to Southeast Missouri?
A roundtrip flight to Southeast Missouri cost as little as $60 over the last seven days. Once you've chosen your travel dates, we'll help you find an amazing deal. This price was available on Travelocity for flights to Southeast Missouri departing within the next year. Prices and availability are subject to change. Additional terms apply.
What is the cheapest month to fly to Southeast Missouri?
Be sure to leave December empty in your calendar, because it's the most affordable month to travel to Southeast Missouri. That's based on Travelocity's direct flight demand from January to December last year. With the cash you save, you can go on a spending spree, go for a fancy dinner or whatever makes you happy.
How can I check my flight status to Southeast Missouri?
Make the most of Travelocity's handy portal, Trips. You'll find just about everything related to your flight to Southeast Missouri here, including details about flight status, gate numbers and more. Look for Trips at the top of the Travelocity homepage. Create your free account and get the answers you need. Or you can access your itinerary while you're on the go and get real-time travel updates through the Travelocity app. You'll find all your itineraries in one place, making it a cinch to share details with any members of your family flying with you.
How do I find the best deals on flights to Southeast Missouri?
Being flexible with your dates is one of the best ways to snag an awesome deal. Travelocity makes it a cinch to find your perfect fare through the "Flexible dates" feature. First, search for your Southeast Missouri flight, then compare prices for surrounding dates by hitting the Flexible dates box above. Booking in advance and avoiding peak travel periods are other steps you can take. In the last seven days, the lowest price for a return flight to Southeast Missouri was $60. This price was available on Travelocity for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
Why should I book my flight to Southeast Missouri with Travelocity?
If you're looking for cheap flights to Southeast Missouri, you'll discover some tempting deals with Travelocity. From cheap family flights with low-cost airlines to flexible tickets, we can help you. Enjoy a worry-free trip with our 24/7 customer support, Price Match Guarantee and free cancellations with most hotels. Start packing your bags and get ready to jump on a plane to this interesting destination.
How much is a flight to Southeast Missouri on average?
Airfares for roundtrip flights to Southeast Missouri were priced between $60 and $1,399 in the last seven days. The minute you spot a good deal, snap it up and get ready for your dream getaway with Travelocity. These prices were available on Travelocity for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
What can I expect on a flight to Southeast Missouri?
Factors like who you're flying with and where you're departing from will mostly determine what you'll be offered on your trip. Chances are you'll find all kinds of flights to Southeast Missouri, from cheap flights for family vacations to premium fares. Warm meals, entertainment and games for the little ones are usually what most airlines offer on long-haul flights.

Plane Tickets To Southeast Missouri

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Southeast Missouri. Browse through our inventory to explore a wide range of cheap flights to Southeast Missouri to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Southeast Missouri as you anxiously await to exit the plane and explore what Southeast Missouri has to offer. Considering all the amazing local food and culture in Southeast Missouri, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Southeast Missouri to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Southeast Missouri without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Southeast Missouri with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Southeast Missouri today!

Explore More Ways to Travel with Travelocity

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.