Southeast Missouri Vacation Packages 2025/2026 from $304

Southeast Missouri flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

The Principal Hotel

$304

per person

Nov 10 - Nov 14

found 2 hours ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

A restaurant and a gym are featured at this hotel. Free self parking, a coffee shop, and dry cleaning are also offered.

The Wildwood Hotel

$462

per person

Nov 8 - Nov 11

found 17 hours ago

Roundtrip flight included

Boston (BOS) to St. Louis (STL)

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

White House at Grand Central

Grand Center

$359

per person

Nov 10 - Nov 14

found 2 hours ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

A garden, express check-in, and express check-out are available at this apartment. Laundry facilities and barbecue grills are also provided.

The West End

Central West End

$360

per person

Nov 10 - Nov 14

found 2 hours ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

A 24-hour gym, self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Express check-out is also provided.

The Cheshire

$413

per person

Oct 13 - Oct 16

found 1 day ago

Roundtrip non-stop flight included

Austin (AUS) to St. Louis (STL)

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal outdoor pool and free English breakfast each morning.

Top Southeast Missouri hotels deals

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St, Farmington, MO

Free Cancellation

Reserve now, pay when you stay

$52 nightly

$59 total

Sep 11 - Sep 12

Total with taxes and fees

This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.

Pool

Breakfast included

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive, Cape Girardeau, MO

Free Cancellation

Reserve now, pay when you stay

$90 nightly

$102 total

Sep 14 - Sep 15

Total with taxes and fees

This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Pool

Hot Tub

The Riverview

777 Main St, Cape Girardeau, MO

Free Cancellation

Reserve now, pay when you stay

$102 nightly

$116 total

Sep 16 - Sep 17

Total with taxes and fees

This hotel features a casino and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. Relax with a drink at one of the 2 bars/lounges and enjoy perks like free self parking.

Parking included

Free WiFi

The Farmstead Hotel

778 E 3rd St, Caruthersville, MO

Free Cancellation

Reserve now, pay when you stay

$122 nightly

$139 total

Sep 8 - Sep 9

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock assistance.

Parking included

Free WiFi

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau, MO

Free Cancellation

Reserve now, pay when you stay

$70 nightly

$79 total

Sep 8 - Sep 9

Total with taxes and fees

Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.

Pet friendly

Free WiFi

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy, Cape Girardeau, MO

Free Cancellation

Reserve now, pay when you stay

$70 nightly

$79 total

Sep 7 - Sep 8

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour business center. A gym and a safe deposit box are also provided.

Breakfast included

Pet friendly

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Taum Sauk Mountain in located in the St.Francis mountain range of south/central Missouri. It's also the highest point in Missouri. My kids are standing at the spot where the actual marker sign in

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Beautiful area. Easy to get up close and not too far off the main road. 🏞 #waterfalls #nature #explore #missouri

Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Breathtaking view at the dam by the road and some small trails for walking as well!

Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Frequently asked questions

How much are vacation packages to Southeast Missouri?

Packages, which include flights and hotels in Southeast Missouri, start at just $304. Make your travel dreams a reality and book your dream trip with Travelocity today.

Where can I get the best vacation package deals for Southeast Missouri?

There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you're ready to cross another place off your travel bucket list.

Why should I book my Southeast Missouri vacation package via Travelocity?

From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you're being taken care of before, during and after your trip. And don't panic if you notice a lower price on your booking, we'll match it. That's our Price Match Guarantee.

Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?

Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.

Which airport is best for Southeast Missouri?

Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.

What is there to do in Southeast Missouri?

Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson's Shut-ins State Park and Meramec Caverns while you're here. These landmarks shouldn't be missed.