Southeast Missouri Vacation Packages 2026 from $665

Southeast Missouri flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

$665

per person

Dec 4 - Dec 6

found 13 hours ago

Roundtrip flight included

Philadelphia (PHL) to St. Louis (STL)

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Marriott St. Louis Airport

Edmundson

$693

per person

Dec 29 - Jan 1

found 6 hours ago

Roundtrip flight included

Philadelphia (PHL) to St. Louis (STL)

This hotel features an indoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center, express check-in, and free airport shuttle. There's a bar/lounge on site, and laundry facilities and concierge services are also provided.

Home2 Suites by Hilton St. Louis Downtown

Downtown West

$692

per person

Dec 29 - Jan 1

found 6 hours ago

Roundtrip flight included

Philadelphia (PHL) to St. Louis (STL)

This hotel doesn't skimp on freebies - guests receive free buffet breakfast and free WiFi. Traveling on business? Take advantage of the 24-hour business center and valet parking. A snack bar/deli and a safe deposit box are also provided.

Hampton Inn St. Charles St. Peters

$677

per person

Nov 25 - Nov 29

found 1 day ago

Roundtrip flight included

Chicago (MDW) to St. Louis (STL)

This hotel features an indoor pool and a 24-hour gym. Enjoy the hot tub and free perks like buffet breakfast and free self parking. A 24-hour business center, free WiFi in public areas, and a picnic area are also on offer.

Four Seasons Hotel St Louis

Downtown St. Louis

$1,164

per person

Dec 29 - Jan 1

found 6 hours ago

Roundtrip flight included

Philadelphia (PHL) to St. Louis (STL)

A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Families will appreciate kid-friendly dining and in-room childcare. Traveling on business? Take advantage of the 24-hour business center, express check-out, and valet parking.

Top Southeast Missouri hotels deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Free Cancellation

Reserve now, pay when you stay

$100 nightly

$113 total

Oct 25 - Oct 26

Total with taxes and fees

This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Pool

Hot Tub

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$94 nightly

$108 total

Oct 25 - Oct 26

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Pool

Breakfast included

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Free Cancellation

Reserve now, pay when you stay

$54 nightly

$61 total

Nov 15 - Nov 16

Total with taxes and fees

This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like full breakfast and free self parking.

Pool

Breakfast included

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

Free Cancellation

Reserve now, pay when you stay

$72 nightly

$81 total

Oct 25 - Oct 26

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour business center. A safe deposit box is provided and the front desk is staffed around-the-clock.

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

Free Cancellation

Reserve now, pay when you stay

$91 nightly

$102 total

Nov 1 - Nov 2

Total with taxes and fees

This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. A business center, express check-in, and express check-out are also on offer.

Pool

Breakfast included

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$66 nightly

$76 total

Nov 1 - Nov 2

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 3 onsite conference rooms. Enjoy the gym and conveniences like a 24-hour front desk and laundry facilities.

Breakfast included

Pet friendly

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

See properties

Frequently asked questions

How much are vacation packages to Southeast Missouri?

Packages, which include flights and hotels in Southeast Missouri, start at just $665. Make your travel dreams a reality and book your dream trip with Travelocity today.

Where can I get the best vacation package deals for Southeast Missouri?

There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you're ready to cross another place off your travel bucket list.

Why should I book my Southeast Missouri vacation package via Travelocity?

From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you're being taken care of before, during and after your trip. And don't panic if you notice a lower price on your booking, we'll match it. That's our Price Match Guarantee.

Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?

Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.

Which airport is best for Southeast Missouri?

Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.

What is there to do in Southeast Missouri?

Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson's Shut-ins State Park and Meramec Caverns while you're here. These landmarks shouldn't be missed.