Book Hotels in Perryville, MO

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Top Perryville hotels

Gorgeous, downtown house!

Gorgeous, downtown house!

Perryville
$277 nightly
The price is $293 total per night from Oct 5 to Oct 6
$293 total
Oct 5 - Oct 6
Total with taxes and fees
This vacation home features a garden, laundry facilities, and barbecue grills.
Women's Bowling Trip
"Our stay was excellent and our host Carisa was a Great person to work with. The house was beautiful. The house worked out great for us. We had 6 people staying and we all had very comfortable beds and our own bathrooms. Great for a large family."

Reviewed on Apr 7, 2025

Opens in a new windowGorgeous, downtown house!
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane, Jackson, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $95 total per night from Oct 6 to Oct 7
$95 total
Oct 6 - Oct 7
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
"All staff were nice and accommodating. The dining area was clean and stocked with various food options during dining times. The room was very clean and tidy."

Reviewed on Sep 26, 2025

Opens in a new windowDrury Inn & Suites Jackson MO
Hot Tub & Creek Views: Secluded Perryville Cabin

Hot Tub & Creek Views: Secluded Perryville Cabin

Perryville
A hot tub is featured at this vacation home, along with laundry facilities and barbecue grills.
"i stayed at the cabin for a week, and enjoyed the peace and quiet of being in the middle of nowhere. i took long walks with my dog, lounged in the hot tub (very nice), gathered eggs from the chickens, learned the history of the cabin, and got together with friends living close by. it's not too far ..."

Reviewed on Sep 16, 2025

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Opens in a new windowHot Tub & Creek Views: Secluded Perryville Cabin
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 out of 5
2520 Veterans Memorial Dr, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $115 total per night from Oct 12 to Oct 13
$115 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features an indoor pool and a gym. Guests will appreciate freebies like daily breakfast and free self parking. Staff at the 24-hour front desk can ...
"Checking in was great lady was very helpful in all ways possible. Thank you!"

Reviewed on Sep 28, 2025

Opens in a new windowTru By Hilton Cape Girardeau
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 out of 5
2020 Jefferson St, Perryville, MO
Fully refundable
$95 nightly
The price is $109 total per night from Oct 19 to Oct 20
$109 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Good varity of food and drinks offered for breakfast."

Reviewed on Sep 28, 2025

Opens in a new windowHoliday Inn Express & Suites Perryville by IHG
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $91 total per night from Oct 5 to Oct 6
$91 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
"My partner and I were in town for a family wedding and stayed for 3 nights. The staff at this hotel were amazing! They were, over the top, friendly and helpful with anything we needed. They allowed us to gather with family outside on the patio and checked on us several times. The room was clean, ..."

Reviewed on Sep 25, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville

2 out of 5
1119 Vincent Dr, Perryville, MO
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $83 total per night from Oct 8 to Oct 9
$83 total
Oct 8 - Oct 9
Total with taxes and fees
This motel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Always a great stay"

Reviewed on Sep 26, 2025

Opens in a new windowSuper 8 by Wyndham Perryville
Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville

2 out of 5
1500 Liberty Street, Perryville, MO
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $81 total per night from Oct 5 to Oct 6
$81 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
"Was a nice place."

Reviewed on Aug 11, 2025

Opens in a new windowDays Inn by Wyndham Perryville
Quality Inn Perryville I-55

Quality Inn Perryville I-55

2.5 out of 5
1517 S. Perryville Blvd., Perryville, MO
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $78 total per night from Oct 9 to Oct 10
$78 total
Oct 9 - Oct 10
Total with taxes and fees
This hotel features an outdoor pool and a gym. Enjoy the hot tub and free perks like daily breakfast and free self parking. The front desk is staffed around-the-clock ...
"This was an overnight trip…Our bathroom was dirty and there weren’t any extra towels or toilet paper in the room. Also the fire alarm went off at 6am without an explanation..They offered yogurt but didn’t have the key to the cabinet."

Reviewed on Aug 11, 2025

Opens in a new windowQuality Inn Perryville I-55
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Perryville Hotel & Travel Guide\n

Are you planning to organize time in Southeast Missouri? Hoping to reserve somewhere to stay in or around Perryville? 3 hotels and apartments are listed within a 6-mile (10-kilometer) radius.

Travelocity-listed hotels that you can book within walking distance of Perryville's city center, are the Super 8 Perryville and Days Inn Perryville.

14 miles (23 kilometers) from the main part of Perryville, you will come across the Best Western Chester Hotel. The Microtel Inn & Suites by Wyndham Sainte Genevieve is situated 20 miles (31 kilometers) away. Two more options around Perryville include the Econo Lodge as well as the Comfort Inn Perryville.

30 miles (48 kilometers) to the west of Perryville, you will reach Farmington, where you can spend the day exploring Missouri Mines State Historic Site and Columbia Park. Farmington rooms include the Holiday Inn Express & Suites Farmington and Hampton Inn Farmington. Or, you could consider staying in Sikeston, 60 miles (98 kilometers) south of Perryville, where you can pick from the Comfort Inn And Suites and Americas Best Value Inn & Suites Sikeston. The Boot Heel Golf Club and Sikeston Depot Museum are a couple of the more frequented attractions to see for those visiting Sikeston.

Give yourself a serving of local sport by making the pilgrimage to Rent One Park, situated 50 miles (80 kilometers) to the east of Perryville. Travelocity users that like the idea of locating a hotel not too far away, book in the Fairfield Inn and Suites by Marriott Marion or Holiday Inn Express Hotel & Suites Marion Northeast.

Perryville features some great family attractions; discover more on our useful Perryville travel page.

Frequently asked questions

What are the top kid-friendly hotels in Perryville?
From thoughtful amenities to extra space, kid-friendly hotels come with features that can help turn a great family vacation into an extraordinary one. These Perryville options make vacationing with young ones a snap: You'll be well taken care of at Urban Lofts. It comes with a pillowtop mattress, a cafe and a commitment to making families feel at home. June Bugs Loft is another great choice. After a big day of exploring Perryville, come home to your comfy room and amenities like a king bed and internet access.
Where can I find cheap hotels in Perryville?
At Travelocity you'll find really nice hotels in Perryville at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Perryville rather than in Perryville. We may find you even better rates, too.
How do I find the best Perryville hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Perryville then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Perryville?
The cheapest hotel in Perryville is $78. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Perryville?
There are 150 hotels in Perryville on Travelocity.
What are the best hotels in Perryville?
Perryville has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Perryville for you!
When is the best time to visit Perryville?
If you want the joy of a fun-filled trip in peak season, visit Perryville during February, March and June. If you'd prefer the peace of off-season, book a stay during quieter months, such as November, December and January.
When is the cheapest time to stay in Perryville?
Based on historic data is usually the cheapest month to visit Perryville. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Perryville?
There are multiple hotels in Perryville that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Perryville. We have plenty of kid-friendly hotels in Perryville to choose from on Travelocity!
Why book a hotel in Perryville through Travelocity?
Because we have the top hotels in Perryville! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Perryville on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Perryville hotel reviews by fellow wanderers

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Checking in was great lady was very helpful in all ways possible. Thank you!"
A verified traveler stayed at Tru By Hilton Cape Girardeau
Tru By Hilton Cape Girardeau

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