Book Hotels in De Soto, MO

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Top De Soto hotels

82 Acre Hobby Farm with Lincoln Log Cabin

82 Acre Hobby Farm with Lincoln Log Cabin

De Soto MO
$265 nightly
The price is $275 total per night from Jan 3 to Jan 4
$275 total
Jan 3 - Jan 4, 2026
Total with taxes and fees
This cabin features a garden, laundry facilities, and barbecue grills.
The cabin was cozy; comfortable; clean; everything we needed; decorated nicely plus Christmas tree and decor; friendly and attentive hosts. There are not enough nice things to say about them. If I could rate it a 20 out of 10 I would. We will stay again if available next time!! There were home laid ...

Reviewed on Dec 8, 2025

Opens in a new window82 Acre Hobby Farm with Lincoln Log Cabin
Secluded cabin on private property

Secluded cabin on private property

De Soto MO
This cabin features a garden, laundry facilities, and barbecue grills.
A beautiful and comfy property with plenty of space inside and out. Well marked paths through the property made it easy to traipse through the woods. And a surprise cup of hot cocoa after a chilly day doing just that was just icing on the cake (no cake though…).

Reviewed on Nov 30, 2025

Opens in a new windowSecluded cabin on private property
Drury Inn & Suites St. Louis Arnold

Drury Inn & Suites St. Louis Arnold

3 out of 5
3800 State Rt 141 Arnold MO
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $142 total per night from Dec 30 to Dec 31
$142 total
Dec 30 - Dec 31
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
I always check in late. The overnight staff is top notch. One time they even called me to make sure I was okay and not lost. I will ALWAYS stay at this Drury Inn!

Reviewed on Dec 16, 2025

Opens in a new windowDrury Inn & Suites St. Louis Arnold
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

2.5 out of 5
1201 Drury Ln Arnold MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $104 total per night from Dec 30 to Dec 31
$104 total
Dec 30 - Dec 31
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Clean hotel, friendly staff, comfortable beds, and decent breakfast. Only problem was a car was broken into in the parking lot overnight.

Reviewed on Dec 14, 2025

Opens in a new windowPear Tree Inn St. Louis Arnold
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

2.5 out of 5
1802 Gamel Cemetery Road Festus MO
Fully refundable
$131 nightly
The price is $150 total per night from Jan 4 to Jan 5
$150 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Clean room. Fast check in. Wish we had 2 coffee cups though! Breakfast was great!

Reviewed on Dec 23, 2025

Opens in a new windowHoliday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Hampton Inn Farmington

Hampton Inn Farmington

2.5 out of 5
850 Valley Creek Dr Farmington MO
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $130 total per night from Jan 16 to Jan 17
$130 total
Jan 16 - Jan 17, 2026
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Enjoy the hot tub and free perks like buffet breakfast and free self parking. A 24-hour business center, ...
Staff was amazing, super clean

Reviewed on Nov 26, 2025

Opens in a new windowHampton Inn Farmington
Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington

2 out of 5
930 Valley Creek Dr Farmington MO
Fully refundableReserve now, pay when you stay
$53 nightly
The price is $60 total per night from Jan 1 to Jan 2
$60 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
A seasonal outdoor pool, free self parking, and laundry facilities are featured at this motel. Guests will appreciate free perks like on-the-go breakfast and ...
The room was excellent and the staff was extremely nice

Reviewed on Nov 25, 2025

Opens in a new windowSuper 8 by Wyndham Farmington
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
$53 nightly
The price is $60 total per night from Jan 2 to Jan 3
$60 total
Jan 2 - Jan 3, 2026
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Yes

Reviewed on Dec 21, 2025

Opens in a new windowBaymont Inn and Suites by Wyndham Farmington, MO
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $106 total per night from Jan 4 to Jan 5
$106 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Breakfast was great! Location right off interstate was perfect. The property is a little old.

Reviewed on Dec 18, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham Festus - St. Louis South
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

De Soto Hotel & Travel Guide\n

Dreaming about exploring De Soto? Travelocity has no hotels and apartments, however, there are 4 places to rest and relax within an easy drive of De Soto.

The nearest Travelocity-listed accommodation is the Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, Missouri, 9 miles (15 kilometers) from the middle of De Soto. Another Travelocity accommodation option is the Lexington Inn - Shalimar Plaza & Conference Center, situated in Missouri, 10 miles (15 kilometers) from the middle of De Soto.

The Comfort Inn is 10 miles (15 kilometers) outside the city center of De Soto. An alternative accommodation option is the Super 8 Pevely, which can be found approximately 14 miles (22 kilometers) away. The Super 8 Potosi Mo as well as the Super 8 Bonne Terre are two other Travelocity-listed accommodation options worth checking out around De Soto.

There are various Travelocity-registered hotels in Pilot Knob, which is situated 35 miles (55 kilometers) south of De Soto. The Fort Davidson Hotel and Shepherd Mountain Inn are a few of the establishments here.

Make sure you get your fix of local sport by making the journey to Busch Stadium, which is 40 miles (64 kilometers) to the northeast of De Soto. Enlightened travelers wanting to find a Travelocity-listed room near to the action can choose from the Four Seasons Hotel St Louis or the Grand Center Inn.

Lambert-St. Louis International Airport is a practical arrival point for flights, and is situated 45 miles (72 kilometers) away from De Soto. Travelocity-listed hotels close to Lambert-St. Louis International Airport include Marriott St. Louis Airport and Holiday Inn St. Louis-Airport.

Frequently asked questions

What are the top kid-friendly hotels in De Soto?
From carefully considered amenities to rooms with bunk beds, kid-friendly hotels are equipped with features that can help transform a nice family vacation into a fantastic one. These De Soto properties make vacationing with your youngsters a snap: Put your bags down at NEW! Traditional Country Home in De Soto w/ Yard!. It comes with a firepit, a fireplace and a flair for making families feel at home. Beautiful 2 bedroom unit at resort, sleeps 6 is also a great choice. After a fun day of exploring, return to your comfy room and perks like a sauna and a king bed.
Where can I find cheap hotels in De Soto?
At Travelocity you'll find really nice hotels in De Soto at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near De Soto rather than in De Soto. We may find you even better rates, too.
How do I find the best De Soto hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in De Soto then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in De Soto?
The cheapest hotel in De Soto is $60. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in De Soto?
There are 174 hotels in De Soto on Travelocity.
What are the best hotels in De Soto?
De Soto has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in De Soto for you!
When is the best time to visit De Soto?
If you want the joy of a fun-filled trip in peak season, visit De Soto during March, April and May. If you'd prefer the peace of off-season, book a stay during quieter months, such as June, October and November.
When is the cheapest time to stay in De Soto?
Based on historic data is usually the cheapest month to visit De Soto. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in De Soto?
There are multiple hotels in De Soto that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to De Soto. We have plenty of kid-friendly hotels in De Soto to choose from on Travelocity!
Why book a hotel in De Soto through Travelocity?
Because we have the top hotels in De Soto! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in De Soto on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

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