Book Hotels in De Soto, MO
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top De Soto hotels

Secluded cabin on private property
"Great place for a small family. We plan on staying again"
Reviewed on Jun 21, 2026

Gated 35-Acre De Soto Estate: Pool, Lake & Patio!
"The home is spacious and superb for large groups with plenty of variety of options for things to do. We stayed in December and as such didn’t use the pool. We would come again, anytime! The host was helpful with addressing our questions and needs."
Reviewed on Dec 28, 2025

82 Acre Hobby Farm with Lincoln Log Cabin
"Everything was perfect"
Reviewed on Jun 13, 2026

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
"Great cozy cabin with wonderful staff to ask any questions"
Reviewed on Jun 17, 2026

Drury Inn & Suites St. Louis Arnold
"We felt like we were with family. The staff was absolutely wonderful. The breakfast was great. The hot tub and pools make it so much more enjoyable. They offer a mini dinner from 5:30 pm to 7:00 pm, which I thought was a great asset, especially for families. The rooms were clean and very comfortable. ..."
Reviewed on Jun 20, 2026

Pear Tree Inn St. Louis Arnold
"This property was great! Will use it again"
Reviewed on Jun 26, 2026

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
"Excellent staff!"
Reviewed on Jun 24, 2026

Baymont Inn and Suites by Wyndham Farmington, MO
"Old hotel and needs work. Checked in and found the toilet seat broken. Asked for another room and switched. Not recommending."
Reviewed on Jun 26, 2026

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
"Great visit overall, highly recommend!!"
Reviewed on Jun 23, 2026
De Soto Hotel & Travel Guide\n
Dreaming about exploring De Soto? Travelocity has no hotels and apartments, however, there are 4 places to rest and relax within an easy drive of De Soto.
The nearest Travelocity-listed accommodation is the Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, Missouri, 9 miles (15 kilometers) from the middle of De Soto. Another Travelocity accommodation option is the Lexington Inn - Shalimar Plaza & Conference Center, situated in Missouri, 10 miles (15 kilometers) from the middle of De Soto.
The Comfort Inn is 10 miles (15 kilometers) outside the city center of De Soto. An alternative accommodation option is the Super 8 Pevely, which can be found approximately 14 miles (22 kilometers) away. The Super 8 Potosi Mo as well as the Super 8 Bonne Terre are two other Travelocity-listed accommodation options worth checking out around De Soto.
There are various Travelocity-registered hotels in Pilot Knob, which is situated 35 miles (55 kilometers) south of De Soto. The Fort Davidson Hotel and Shepherd Mountain Inn are a few of the establishments here.
Make sure you get your fix of local sport by making the journey to Busch Stadium, which is 40 miles (64 kilometers) to the northeast of De Soto. Enlightened travelers wanting to find a Travelocity-listed room near to the action can choose from the Four Seasons Hotel St Louis or the Grand Center Inn.
Lambert-St. Louis International Airport is a practical arrival point for flights, and is situated 45 miles (72 kilometers) away from De Soto. Travelocity-listed hotels close to Lambert-St. Louis International Airport include Marriott St. Louis Airport and Holiday Inn St. Louis-Airport.
Frequently asked questions
Recent De Soto hotel reviews by fellow wanderers

Pear Tree Inn St. Louis Arnold
"This property was great! Will use it again"
Explore More Ways to Travel with Travelocity
- House Springs Hotels
- Apartments in Valles Mines
- Extended Stay Hotels in Valles Mines
- Vacation Homes in Valles Mines
- 3 Star Hotels in Festus
- Farmstay in Festus
- Apartments in Festus
- B&B in Festus
- Cabins in Festus
- Condos in Festus
- Extended Stay Hotels in Festus
- Guest Houses in Festus
- Cheap Hotels in Festus
- Kid Friendly Hotels in Festus
- Hotels with Bar in Festus
- Hotels with an Indoor Pool in Festus
- Pet Friendly Hotels in Festus
- Hotels with Shopping in Festus
- Festus Hotels
- Inns in Festus
- Motels in Festus
- Rv Parks in Festus
- Villas in Festus
- Hotels near St. Joe State Park
- Park Hills Hotels
- Hotels near Crown Pointe Golf Club
- Arnold Hotels
- B&B in Hillsboro
- Cabins in Hillsboro
- Condos in Hillsboro
- Extended Stay Hotels in Hillsboro
- Drury Inn & Suites Hotels in Hillsboro
- Hillsboro Hotels
- Motels in Hillsboro
- Vacation Homes in Hillsboro
- Rv Parks in Hillsboro
- Villas in Hillsboro
- Leadington Hotels
- Flat River Hotels
- Cabins in Tiff
- Tiff Hotels
- Lodges in Tiff
- Bloomsdale Hotels
- Hotels near St. James Catholic Church
- Scotsdale Hotels
- 3 Star Hotels in Dittmer
- 5 Star Hotels in Dittmer
- Apartments in Dittmer
- Extended Stay Hotels in Dittmer
- Dittmer Hotels
- Motels in Dittmer
- Vacation Homes in Dittmer
- Potosi Hotels
- B&B in Cadet
- Cabins in Cadet
- Cadet Hotels
- Lodges in Cadet
- Motels in Cadet
- Imperial Hotels
- Lodges in Crystal City
- Vacation Homes in Crystal City
- Hotels near Myron and Sonya Glassberg Family Conservation Area
- Hotels near St. Francois State Park
- Hotels near Washington State Park
- Hotels near Bonne Terre Mine
- Leadwood Hotels
- Hotels near Robertsville State Park
- Irondale Hotels
- Bonne Terre Hotels
- Apartments in Pevely
- B&B in Pevely
- Cabins in Pevely
- Chalets in Pevely
- Extended Stay Hotels in Pevely
- Convention Center Hotels in Pevely
- Hotels with Hot Tubs in Pevely
- Luxury Hotels in Pevely
- Pevely Hotels
- Motels in Pevely
- Vacation Homes in Pevely
- Villas in Pevely
- Cabins in Barnhart
- Barnhart Hotels
- Hematite Hotels
- Farmstay in Herculaneum
- B&B in Herculaneum
- Cabins in Herculaneum
- Herculaneum Hotels
- Motels in Herculaneum
- Desloge Hotels






