Find and compare 3 Star hotels in Southeast Missouri

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Top Southeast Missouri 3 Star hotels

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Jan 7 to Jan 8
$102 total
Jan 7 - Jan 8
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9.4/10 Exceptional! (1,007 reviews)
Everything was very clean. The food was excellent, the room was spacious, clean, and comfortable!

Reviewed on Jan 2, 2026

Opens in a new windowDrury Plaza Hotel Cape Girardeau Conference Center
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3 out of 5
2781 N Westwood Blvd Poplar Bluff MO
Fully refundable
$110 nightly
The price is $124 total per night from Jan 8 to Jan 9
$124 total
Jan 8 - Jan 9
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
8.6/10 Excellent! (708 reviews)
The front desk woman was great

Reviewed on Dec 21, 2025

Opens in a new windowHoliday Inn Poplar Bluff by IHG
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $87 total per night from Jan 4 to Jan 5
$87 total
Jan 4 - Jan 5
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
8.8/10 Excellent! (679 reviews)
Friendly staff

Reviewed on Dec 26, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $103 total per night from Jan 11 to Jan 12
$103 total
Jan 11 - Jan 12
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.4/10 Exceptional! (1,003 reviews)
Everything was great

Reviewed on Dec 29, 2025

Opens in a new windowDrury Inn & Suites Sikeston, MO
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3 out of 5
2220 N Westwood Blvd Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $119 total per night from Jan 10 to Jan 11
$119 total
Jan 10 - Jan 11
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.2/10 Wonderful! (969 reviews)
We’ve stayed here many times. It’s always clean and comfortable! Beds are amazing!

Reviewed on Dec 27, 2025

Opens in a new windowDrury Inn & Suites Poplar Bluff
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St. Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $124 total per night from Jan 11 to Jan 12
$124 total
Jan 11 - Jan 12
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9.4/10 Exceptional! (469 reviews)
We had a great stay, the hotel is nice and clean. The staff was very friendly and welcoming!

Reviewed on Dec 1, 2025

Opens in a new windowCourtyard by Marriott Cape Girardeau Downtown
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Jan 7 to Jan 8
$102 total
Jan 7 - Jan 8
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.4/10 Exceptional! (999 reviews)
Clean and very nice room

Reviewed on Dec 24, 2025

Opens in a new windowDrury Inn & Suites Cape Girardeau
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3 out of 5
1317 E Highway 84 Hayti MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $107 total per night from Jan 9 to Jan 10
$107 total
Jan 9 - Jan 10
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.2/10 Wonderful! (1,001 reviews)
Fresh breakfast

Reviewed on Dec 17, 2025

Opens in a new windowDrury Inn & Suites Hayti Caruthersville
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $107 total per night from Jan 4 to Jan 5
$107 total
Jan 4 - Jan 5
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
7.8/10 Good! (893 reviews)
Room was clean. Towels were nice. Shower was hot. Breakfast was good.

Reviewed on Dec 25, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham Festus - St. Louis South
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane Jackson MO
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $88 total per night from Jan 4 to Jan 5
$88 total
Jan 4 - Jan 5
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.6/10 Exceptional! (1,003 reviews)
It was so wonderful. I really enjoyed my time there. My children enjoyed their time there. The workers was all nice and very sweet and caring and help me with so much that I need to help with. I definitely would like to come back.

Reviewed on Jan 2, 2026

Opens in a new windowDrury Inn & Suites Jackson MO
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

3 Star Hotels Southeast Missouri

Maybe you’ve got to travel for work, or perhaps you’re finally ready to book that much-deserved vacation—regardless, it’s time for you to get on a plane and you’re going to make the most of it. You’ve traveled enough to know how important a comfy bed and room service can be, so booking a hotel with all the amenities you need is a priority.

You can find 3 star hotels in Southeast Missouri that keep you close to all the great sightseeing and activities around the area, or even book a place that’s a bit more secluded, if that’s what you prefer. No matter what you’re looking for—whether you’re all about the location or are invested in on-site perks--Travelocity will help you find the accommodation that works best for you.

When it comes to options, you’ll have them. The Southeast Missouri 3 star hotels give you plenty of choices as far as access to the best areas, and many also offer a breakfast buffet, as well as plenty of other amenities like high-speed Wi-Fi and an on-site pool or spa.

Whatever you’re looking for on your next getaway, browse Travelocity’s big selection of hotels to ensure you get the best possible deal. Book one of the best 3 star hotels in Southeast Missouri today!

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