Cheap Flights to Southeast Missouri from $44

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How Much Does it Cost To Fly To Southeast Missouri?

The cheapest prices found with in the last 7 days for return flights were $78 and $44 for one-way flights to Southeast Missouri for the period specified. Prices and availability are subject to change. Additional terms apply

OriginDestinationTravel DatesFlights From*
MSPSt. LouisApril 14 to April 21$99
BWISt. LouisApril 10 to April 15$174
EWRSt. LouisMay 12 to May 16$181
DCASt. LouisApril 15 to April 18$182
LAXSt. LouisApril 16 to April 23$216
MSYSt. LouisApril 10 to April 14$218
CMHSt. LouisApril 7 to April 9$221
MCISt. LouisApril 21 to April 23$239
DCAWest PaducahMay 21 to May 24$306
STLWest PaducahApril 17 to April 18$519
LAXScott CityMay 18 to May 22$674
SATWest PaducahMarch 24 to March 25$690
LAXWest PaducahMarch 24 to March 25$908
BWIMarionMay 7 to May 11$1,419
MSPScott CityApril 8 to April 10$6,918
*Prices include taxes and fees
OriginDestinationTravel DatesFlights From*
MSPSt. LouisMarch 22 to March 23$265
BWISt. LouisMarch 21 to March 23$280
EWRSt. LouisMarch 20 to March 24$341
SATSt. LouisMarch 20 to March 22$414
LAXSt. LouisMarch 22 to March 25$487
MCISt. LouisMarch 22 to March 23$509
DCASt. LouisMarch 20 to March 22$753
*Prices include taxes and fees

Southeast Missouri Flight Information

Traveling to
Southeast Missouri
Lowest Price
$78
Number of Airlines Serving
Airlines Serving
Frontier Airlines
Number of Daily Flights
Airlines with Direct Flights

Find The Perfect Hotel For After Your Flight

Amazing Southeast Missouri Accommodation Deals

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
The price is $74 total per night from Mar 14 to Mar 15
$74 total
per night
Mar 14 - Mar 15
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,001 reviews)
Staff was nice, place looked clean, (Arrived late at Night.) Shower towels and wash cloths were very small and thin like paper towels and shower curtains allowed a lot of water into bathroom floor.

Reviewed on Mar 13, 2026

Opens in a new windowMotel 6 Poplar Bluff, MO
Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington

2 out of 5
930 Valley Creek Dr Farmington MO
The price is $68 total per night from Mar 22 to Mar 23
$68 total
per night
Mar 22 - Mar 23
Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (627 reviews)
Parking was easy. The property is in the process of being updated, so the rooms, carpet, paint are all new. Looks good. Breakfast is ok, but there are no protein items (eggs, bacon/sausage).

Reviewed on Mar 12, 2026

Opens in a new windowSuper 8 by Wyndham Farmington
Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2 out of 5
1711 Highway Z Pevely MO
The price is $87 total per night from Mar 22 to Mar 23
$87 total
per night
Mar 22 - Mar 23
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (836 reviews)
Room was not clean

Reviewed on Mar 12, 2026

Opens in a new windowSuper 8 by Wyndham Pevely
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Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
The price is $81 total per night from Mar 17 to Mar 18
$81 total
per night
Mar 17 - Mar 18
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,001 reviews)
Yes

Reviewed on Mar 10, 2026

Opens in a new windowPear Tree Inn Cape Girardeau West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Southeast Missouri

Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2 out of 5
1711 Highway Z Pevely MO
The price is $87 total per night from Mar 22 to Mar 23
$87 total
per night
Mar 22 - Mar 23
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (836 reviews)
Room was not clean

Reviewed on Mar 12, 2026

Opens in a new windowSuper 8 by Wyndham Pevely
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
The price is $74 total per night from Mar 14 to Mar 15
$74 total
per night
Mar 14 - Mar 15
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,001 reviews)
Staff was nice, place looked clean, (Arrived late at Night.) Shower towels and wash cloths were very small and thin like paper towels and shower curtains allowed a lot of water into bathroom floor.

Reviewed on Mar 13, 2026

Opens in a new windowMotel 6 Poplar Bluff, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
The price is $78 total per night from Mar 16 to Mar 17
$78 total
per night
Mar 16 - Mar 17
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,003 reviews)
Close access to I-55.

Reviewed on Mar 11, 2026

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
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Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Riverfront Park and eDen Spa & Salon are located ...
10/10 Exceptional! (224 reviews)
Great location, quality bedding and pillows, and other comfortable amenities for a short getaway in historic downtown Cape Girardeau. Excellent value!

Reviewed on Dec 15, 2025

Opens in a new windowHistorical 'Kage House' Short Term Rental located in "Old Town Cape"
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Southeast Missouri

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
The price is $108 total per night from Mar 18 to Mar 19
$108 total
per night
Mar 18 - Mar 19
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,003 reviews)
We didn’t use the pool but the happy hour/ buffet was delicious! Breakfast was very nice!! Room was very clean and staff friendly and helpful

Reviewed on Mar 12, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
The price is $93 total per night from Mar 22 to Mar 23
$93 total
per night
Mar 22 - Mar 23
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,002 reviews)
nice and covenant have stay here a few times, staff always has a smile.

Reviewed on Mar 10, 2026

Opens in a new windowBest Western Plus Sikeston I-55
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
The price is $102 total per night from Mar 17 to Mar 18
$102 total
per night
Mar 17 - Mar 18
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,000 reviews)
Easy parking. Very clean room. Accommodating. Nice and helpful staff.

Reviewed on Mar 11, 2026

Opens in a new windowDrury Inn & Suites Cape Girardeau
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Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd Jackson MO
The price is $100 total per night from Mar 15 to Mar 16
$100 total
per night
Mar 15 - Mar 16
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
8.2/10 Very Good! (750 reviews)
Beds felt amazing. My family and I had a great time

Reviewed on Mar 10, 2026

Opens in a new windowComfort Suites Jackson-Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best Southeast Missouri Flight and Hotel Packages

Southeast Missouri flight + hotel packages - economy flights

Price found within the past 48 hours. Click for updated prices.
Hilton Pennywell St. Louis at the Arch
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Home2 Suites by Hilton St. Louis Downtown
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Frequently asked questions

How much is the cheapest flight to Southeast Missouri?
A roundtrip flight to Southeast Missouri cost as little as $78 over the last seven days. Once you've chosen your travel dates, we'll help you find an amazing deal. This price was available on Travelocity for flights to Southeast Missouri departing within the next year. Prices and availability are subject to change. Additional terms apply.
What is the cheapest month to fly to Southeast Missouri?
Be sure to leave April empty in your calendar, because it's the most affordable month to travel to Southeast Missouri. That's based on Travelocity's direct flight demand from January to December last year. With the cash you save, you can go on a spending spree, go for a fancy dinner or whatever makes you happy.
How can I check my flight status to Southeast Missouri?
Make the most of Travelocity's handy portal, Trips. You'll find just about everything related to your flight to Southeast Missouri here, including details about flight status, gate numbers and more. Look for Trips at the top of the Travelocity homepage. Create your free account and get the answers you need. Or you can access your itinerary while you're on the go and get real-time travel updates through the Travelocity app. You'll find all your itineraries in one place, making it a cinch to share details with any members of your family flying with you.
How do I find the best deals on flights to Southeast Missouri?
Being flexible with your dates is one of the best ways to snag an awesome deal. Travelocity makes it a cinch to find your perfect fare through the "Flexible dates" feature. First, search for your Southeast Missouri flight, then compare prices for surrounding dates by hitting the Flexible dates box above. Booking in advance and avoiding peak travel periods are other steps you can take. In the last seven days, the lowest price for a return flight to Southeast Missouri was $78. This price was available on Travelocity for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
Why should I book my flight to Southeast Missouri with Travelocity?
If you're looking for cheap flights to Southeast Missouri, you'll discover some tempting deals with Travelocity. From cheap family flights with low-cost airlines to flexible tickets, we can help you. Enjoy a worry-free trip with our 24/7 customer support, Price Match Guarantee and free cancellations with most hotels. Start packing your bags and get ready to jump on a plane to this interesting destination.
How much is a flight to Southeast Missouri on average?
Airfares for roundtrip flights to Southeast Missouri were priced between $78 and $6,918 in the last seven days. The minute you spot a good deal, snap it up and get ready for your dream getaway with Travelocity. These prices were available on Travelocity for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
What can I expect on a flight to Southeast Missouri?
Factors like who you're flying with and where you're departing from will mostly determine what you'll be offered on your trip. Chances are you'll find all kinds of flights to Southeast Missouri, from cheap flights for family vacations to premium fares. Warm meals, entertainment and games for the little ones are usually what most airlines offer on long-haul flights.

Plane Tickets To Southeast Missouri

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Southeast Missouri. Browse through our inventory to explore a wide range of cheap flights to Southeast Missouri to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Southeast Missouri as you anxiously await to exit the plane and explore what Southeast Missouri has to offer. Considering all the amazing local food and culture in Southeast Missouri, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Southeast Missouri to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Southeast Missouri without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Southeast Missouri with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Southeast Missouri today!

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*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.