Cheap Flights to Southeast Missouri from $29
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How Much Does it Cost To Fly To Southeast Missouri?
The cheapest prices found with in the last 7 days for return flights were $58 and $29 for one-way flights to Southeast Missouri for the period specified. Prices and availability are subject to change. Additional terms apply
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$58 Roundtrip, found 7 hours ago
$58
Roundtrip
found 7 hours ago
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| EWR | St. Louis | August 4 to August 11 | $220 |
| BWI | St. Louis | September 3 to September 5 | $240 |
| CMH | St. Louis | October 1 to October 4 | $256 |
| LAX | St. Louis | September 26 to September 28 | $269 |
| MSP | West Paducah | August 14 to August 16 | $301 |
| EWR | Marion | July 9 to July 10 | $530 |
| STL | Marion | July 18 to July 20 | $571 |
| MSP | Marion | July 10 to July 13 | $670 |
| MSP | Scott City | July 21 to July 28 | $680 |
| LAX | Scott City | August 10 to August 25 | $695 |
| LAX | West Paducah | August 17 to August 18 | $749 |
| LAX | Marion | July 20 to July 24 | $751 |
| MCI | Scott City | August 5 to August 7 | $870 |
| BWI | Marion | July 15 to July 20 | $1,237 |
| DCA | Scott City | July 20 to July 23 | $1,382 |
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| DCA | St. Louis | July 4 to July 8 | $323 |
| BWI | St. Louis | July 4 to July 8 | $323 |
| MSY | West Paducah | July 3 to July 5 | $351 |
| LAX | St. Louis | July 4 to July 9 | $367 |
| EWR | St. Louis | July 5 to July 9 | $372 |
| CMH | St. Louis | July 3 to July 5 | $415 |
| MSP | St. Louis | July 5 to July 11 | $686 |
| MCI | St. Louis | July 4 to July 8 | $751 |
| MSY | St. Louis | July 5 to July 17 | $813 |
| SAT | St. Louis | July 5 to July 9 | $968 |
| MSP | West Paducah | July 5 to July 6 | $1,237 |
| MCI | Marion | July 3 to July 5 | $1,857 |
Southeast Missouri Flight Information
Traveling to | Southeast Missouri |
|---|---|
Lowest Price | $58 |
Number of Airlines Serving | |
Airlines Serving | Frontier Airlines |
Number of Daily Flights | |
Airlines with Direct Flights |
Find The Perfect Hotel For After Your Flight
Amazing Southeast Missouri Accommodation Deals
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
$79 nightly
The price is $88 total per night from Jul 6 to Jul 7
$88 total
Jul 6 - Jul 7
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,000 reviews)
"Room was clean, staff were friendly. The bench in the gazebo was broke but we didn't use that area I just saw it. There were some loud guests with kids running around at midnight but that can happen at any hotel. My recommendation would be more than two pillows per bed. This is our second year staying ..."
Reviewed on Jun 27, 2026
Super 8 by Wyndham Farmington
930 Valley Creek Dr Farmington MO
$62 nightly
The price is $68 total per night from Jul 12 to Jul 13
$68 total
Jul 12 - Jul 13
Total with taxes and fees
Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (660 reviews)
"Appreciated the outdoor pool after a hot day of hiking and outdoor activity. Also really appreciated that front desk staff immediately put me in a different but identical room after I walked into the first room, tried to close the shade and the cord totally broke. I was very comfortable, had all ..."
Reviewed on Jun 25, 2026
Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
$64 nightly
The price is $73 total per night from Jul 30 to Jul 31
$73 total
Jul 30 - Jul 31
Total with taxes and fees
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (855 reviews)
"Had a suite... one bed was fine, the other had spring issues. Pull out couch was placed in a spot that it couldn't pull out because a bed was in the way. Front desk was not available when we needed to request more towels. Breakfast was sub par, with no protein or fruit options. Fitness center was ..."
Reviewed on Jun 20, 2026
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Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
$72 nightly
The price is $81 total per night from Jul 5 to Jul 6
$81 total
Jul 5 - Jul 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,000 reviews)
"The staff was extremely friendly. The charger in my room didn't work and the front desk worker allowed me to borrow one. She was extremely helpful. Breakfast was really good and my room was very clean. Bed was comfy and I had everything I needed. Would definitely stay again."
Reviewed on Jun 21, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Luxury Hotels in Southeast Missouri
Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
$64 nightly
The price is $73 total per night from Jul 30 to Jul 31
$73 total
Jul 30 - Jul 31
Total with taxes and fees
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (855 reviews)
"Had a suite... one bed was fine, the other had spring issues. Pull out couch was placed in a spot that it couldn't pull out because a bed was in the way. Front desk was not available when we needed to request more towels. Breakfast was sub par, with no protein or fruit options. Fitness center was ..."
Reviewed on Jun 20, 2026
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
$79 nightly
The price is $88 total per night from Jul 6 to Jul 7
$88 total
Jul 6 - Jul 7
Total with taxes and fees
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,000 reviews)
"Room was clean, staff were friendly. The bench in the gazebo was broke but we didn't use that area I just saw it. There were some loud guests with kids running around at midnight but that can happen at any hotel. My recommendation would be more than two pillows per bed. This is our second year staying ..."
Reviewed on Jun 27, 2026
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
$69 nightly
The price is $78 total per night from Jul 26 to Jul 27
$78 total
Jul 26 - Jul 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
"The air conditioning was good! But not very clean room. Hair everywhere. Strange fluids on bed and couch. Very spacious. You get what you pay for."
Reviewed on Jun 29, 2026
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Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Riverfront Park and eDen Spa & Salon are located ...
10/10 Exceptional! (227 reviews)
"This was a great place to stay in the historical downtown Cape area! The location was very convenient to many shops and restaurants and the property was very well taken care of and clean. We look forward to staying here again!"
Reviewed on Jun 18, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Family Friendly Hotels in Southeast Missouri
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
$111 nightly
The price is $128 total per night from Jul 6 to Jul 7
$128 total
Jul 6 - Jul 7
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,000 reviews)
"Very clean"
Reviewed on Jul 1, 2026
Best Western Plus Sikeston I-55
120 S Interstate Drive Sikeston MO
$85 nightly
The price is $97 total per night from Jul 26 to Jul 27
$97 total
Jul 26 - Jul 27
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,006 reviews)
"The room was clean. It is a little run down but not too bad at all. Be aware that you have to get a new key everyday. They didn't harass us over needing extra towels the first night but they ran out of towels the second night which is weird."
Reviewed on Jun 29, 2026
Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
$93 nightly
The price is $105 total per night from Jul 5 to Jul 6
$105 total
Jul 5 - Jul 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,003 reviews)
"We had a very good experience at this hotel. The rooms are spacious & very clean. The staff were wonderful, helpful and friendly. The breakfast was outstanding. Would definitely stay here again."
Reviewed on Jun 30, 2026
Save an average of 15% on thousands of hotels when you're signed in
Comfort Suites Jackson-Cape Girardeau
2904 Old Orchard Rd Jackson MO
$92 nightly
The price is $100 total per night from Jul 4 to Jul 5
$100 total
Jul 4 - Jul 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
8.2/10 Very Good! (771 reviews)
"We stayed at Comfort Suites in Jackson, Missouri, for two nights and had a very pleasant experience overall. The rooms could use a few cosmetic updates and minor touch-ups, but they were clean, comfortable, and well-maintained where it mattered most. The staff was friendly, welcoming, and helpful ..."
Reviewed on Jun 21, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Best Southeast Missouri Flight and Hotel Packages
Southeast Missouri flight + hotel packages - economy flights
Price found within the past 48 hours. Click for updated prices.
Don't see what you're looking for?
See all available trips from Portland to Southeast Missouri
View all tripsNeed a Car For After Your Flight?
Economy
West Paducah, Kentucky, USA
$58
$174 total
found 1 day ago
Compact
West Paducah, Kentucky, USA
$60
$180 total
found 1 day ago
Midsize
West Paducah, Kentucky, USA
$62
$186 total
found 1 day ago
Standard
West Paducah, Kentucky, USA
$63
$188 total
found 1 day ago
Frequently asked questions
Plane Tickets To Southeast Missouri
Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Southeast Missouri. Browse through our inventory to explore a wide range of cheap flights to Southeast Missouri to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Southeast Missouri as you anxiously await to exit the plane and explore what Southeast Missouri has to offer. Considering all the amazing local food and culture in Southeast Missouri, we won't hold this against you.
When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Southeast Missouri to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Southeast Missouri without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Southeast Missouri with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Southeast Missouri today!
More Ways To Wander
Southeast Missouri Hotels
Find the perfect hotel after your flight
Southeast Missouri Vacation Rentals
Great Deals on alternative accommodations
Southeast Missouri Car Rentals
Affordable cars to get you around town
Southeast Missouri Vacations
Save more by combining flights, hotels and cars
Things to do in Southeast Missouri
Activities, attractions and tours
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