Book Hotels in Upstate South Carolina, SC
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Top Upstate South Carolina hotels
Hotel Hartness
120 Halston Avenue Greenville SC
Fully refundableReserve now, pay when you stay
$219 nightly
The price is $241 total per night from Jul 19 to Jul 20
$241 total
Jul 19 - Jul 20
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...
"I have loved this hotel since it opened, and I have given it rave reviews in the past. I stay at least once a year, but this trip was definitely a surprise. If you are a repeat guest and you haven’t been around since December, then you’ll be sad to find as I was that the vibe has changed from what ..."
Reviewed on Jul 11, 2026
Grand Bohemian Lodge Greenville, Autograph Collection
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$361 nightly
The price is $396 total per night from Aug 2 to Aug 3
$396 total
Aug 2 - Aug 3
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
"Perfect location to visit downtown , staff was very helpful and valet was top notch. We stayed in a suite and had the best view of the falls , great property."
Reviewed on Jul 11, 2026
Best Western Plus Greenville I-385 Inn & Suites
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $91 total per night from Jul 19 to Jul 20
$91 total
Jul 19 - Jul 20
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
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Reviewed on Jul 10, 2026
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $107 total per night from Aug 2 to Aug 3
$107 total
Aug 2 - Aug 3
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Courteous, helpful staff. Great amenities."
Reviewed on Jul 9, 2026
Hyatt Regency Greenville
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$157 nightly
The price is $172 total per night from Jul 19 to Jul 20
$172 total
Jul 19 - Jul 20
Total with taxes and fees
This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"very nice hotel but the rooms and hallways need updating"
Reviewed on Jul 10, 2026
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
$85 nightly
The price is $93 total per night from Aug 2 to Aug 3
$93 total
Aug 2 - Aug 3
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Clean rooms, comfortable beds and nice staff members. Over great experience"
Reviewed on Jul 11, 2026
Hilton Greenville
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$117 nightly
The price is $129 total per night from Jul 26 to Jul 27
$129 total
Jul 26 - Jul 27
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
"Everything was excellent"
Reviewed on Jul 12, 2026
Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Jul 13 to Jul 14
$106 total
Jul 13 - Jul 14
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"Room was clean as taff was nice our bathroom pipes were making sounds in the room so they let us Change rooms with no issues. The new girl at the front desk was new and very kind but charged us after we had reservation with Expedia but that is being credited to us. Expedia helped in that situation. ..."
Reviewed on Jul 10, 2026
Hyatt Place Greenville/Haywood
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $92 total per night from Aug 10 to Aug 11
$92 total
Aug 10 - Aug 11
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"N/A"
Reviewed on Jul 12, 2026
Don't see what you're looking for?
See all available properties in Upstate South Carolina
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cheap Upstate South Carolina hotels
Baymont by Wyndham Anderson Clemson
128 Interstate Blvd Anderson SC
$57 nightly
The price is $63 total per night from Jul 19 to Jul 20
$63 total
Jul 19 - Jul 20
Total with taxes and fees
7/10 Good! (900 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Upstate South Carolina with star-rating
Check Upstate South Carolina Hotels by Star Rating
4 Star Hotels
32 properties
Recent Upstate South Carolina hotel reviews by fellow wanderers
Hilton Greenville
4 out of 5
Posted 3 hours ago
Travelocity Verified Review
"Everything was excellent"
A verified traveler stayed at Hilton Greenville
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