Book Hotels in Upstate South Carolina, SC

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Top Upstate South Carolina hotels

Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson SC
Free WiFi in public areas is available at this cottage.
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Opens in a new windowWooded Cottage - 3 Mi to Clemson University
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$276 nightly
The price is $304 total per night from Nov 30 to Dec 1
$304 total
Nov 30 - Dec 1
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...
Will definitely be back !!

Reviewed on Nov 11, 2025

Opens in a new windowGrand Bohemian Lodge Greenville, Autograph Collection
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $92 total per night from Nov 23 to Nov 24
$92 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
We had a great time. We enjoyed the clean room, breakfast, and great service!

Reviewed on Nov 12, 2025

Opens in a new windowBest Western Plus Greenville I-385 Inn & Suites
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$164 nightly
The price is $180 total per night from Nov 23 to Nov 24
$180 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Convenient to Main Street area.

Reviewed on Nov 8, 2025

Opens in a new windowHyatt Regency Greenville
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
851 Congaree Rd Greenville SC
Fully refundable
$91 nightly
The price is $100 total per night from Nov 23 to Nov 24
$100 total
Nov 23 - Nov 24
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Parking was fine. Did not eat breakfast.

Reviewed on Nov 12, 2025

Opens in a new windowCrowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $101 total per night from Nov 23 to Nov 24
$101 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
Everything was great

Reviewed on Nov 14, 2025

Opens in a new windowHilton Greenville
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $103 total per night from Nov 23 to Nov 24
$103 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Restaurant connected to hotel

Reviewed on Nov 4, 2025

Opens in a new windowBest Western Plus Clemson Hotel & Conference Center
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd Seneca SC
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $89 total per night from Dec 7 to Dec 8
$89 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
Clean room w fridge and microwave Comfy bed

Reviewed on Nov 15, 2025

Opens in a new windowQuality Inn Seneca Clemson Area US-123
La Quinta Inn & Suites by Wyndham Greenville Haywood

La Quinta Inn & Suites by Wyndham Greenville Haywood

3 out of 5
65 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $82 total per night from Nov 23 to Nov 24
$82 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. ...
Q

Reviewed on Nov 3, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham Greenville Haywood
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Upstate South Carolina hotels

Baymont by Wyndham Anderson Clemson

Baymont by Wyndham Anderson Clemson

128 Interstate Blvd Anderson SC
$60 nightly
The price is $66 total per night from Dec 1 to Dec 2
$66 total
Dec 1 - Dec 2
Total with taxes and fees
7/10 Good! (831 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Upstate South Carolina hotel reviews by fellow wanderers

Hyatt Place Greenville/Haywood

Hyatt Place Greenville/Haywood

5 out of 5
Posted 1 day ago
Travelocity Verified Review
"James checked us in on 11/15 and was absolutely kind and courteous! We were only there for one night for a soccer tournament and he made us feel so welcomed and went above and beyond! Will definitely stay here again on our next tournament weekend!"
A verified traveler stayed at Hyatt Place Greenville/Haywood
Hyatt Place Greenville/Haywood

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