Book Hotels in Upstate South Carolina, SC

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Check hotel availability in Upstate South Carolina

Tonight
Check prices in Upstate South Carolina for tonight, Dec 4 - Dec 5
Dec 4 - Dec 5
Tomorrow night
Check prices in Upstate South Carolina for tomorrow night, Dec 5 - Dec 6
Dec 5 - Dec 6
Next weekend
Check prices in Upstate South Carolina for next weekend, Dec 9 - Dec 11
Dec 9 - Dec 11

Most frequently booked Upstate South Carolina hotels

Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd, Greenville, SC, 29607-3521
Free Cancellation
Reserve now, pay when you stay
5.19 mi from city center
The price is $89 per night
$89
per night
Dec 11 - Dec 12
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 2 conference rooms, as well as the business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.
Pool
Free WiFi
Comfort Inn Greenville - Haywood Mall

Comfort Inn Greenville - Haywood Mall

2.5 out of 5
246 Congaree Road, Greenville, SC, 29607-2708
Free Cancellation
Reserve now, pay when you stay
6.47 mi from city center
The price is $78 per night
$78
per night
Dec 11 - Dec 12
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.
Pool
Free WiFi
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr, Greenville, SC, 29615-3538
Free Cancellation
Reserve now, pay when you stay
6.7 mi from city center
The price is $101 per night
$101
per night
Dec 17 - Dec 18
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 8 conference rooms, as well as dry cleaning/laundry services and WiFi in public areas. Free self parking, a terrace, and a garden are also offered.
Parking included
Pet friendly
Holiday Inn Woodruff Road, an IHG Hotel

Holiday Inn Woodruff Road, an IHG Hotel

3 out of 5
25 OLD COUNTRY ROAD, Greenville, SC, 29607
Free Cancellation
4.27 mi from city center
The price is $98 per night
$98
per night
Dec 6 - Dec 7
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Relax with a drink at the bar/lounge and enjoy perks like free self parking.
Pool
Free WiFi
Hyatt Place Greenville/Downtown

Hyatt Place Greenville/Downtown

3 out of 5
128 East Broad Street, Greenville, SC, 29601
Free Cancellation
8.51 mi from city center
The price is $134 per night
$134
per night
Dec 11 - Dec 12
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 4 conference rooms, 24-hour business center, and valet parking. Enjoy the 24-hour gym and free perks like continental breakfast and WiFi in public areas.
Pool
Free WiFi
Cambria Hotel Greenville

Cambria Hotel Greenville

3 out of 5
135 Carolina Point Parkway, Greenville, SC, 29607
Free Cancellation
Reserve now, pay when you stay
3.86 mi from city center
The price is $107 per night
$107
per night
Dec 18 - Dec 19
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the seasonal outdoor pool and perks like free self parking.
Pool
Free WiFi
La Quinta Inn & Suites by Wyndham Greenville Haywood

La Quinta Inn & Suites by Wyndham Greenville Haywood

2.5 out of 5
65 W Orchard Park Dr, Greenville, SC, 29615-3538
Free Cancellation
Reserve now, pay when you stay
6.84 mi from city center
The price is $81 per night
$81
per night
Dec 11 - Dec 12
This hotel features a gym and a seasonal outdoor pool. Guests will appreciate free perks like free self parking and WiFi in public areas. A business center, a terrace, and a garden are also on offer.
Pool
Free WiFi
Best Western Greenville Airport Inn

Best Western Greenville Airport Inn

2.5 out of 5
5009 Pelham Road, Greenville, SC, 29615-5465
Free Cancellation
Reserve now, pay when you stay
6.02 mi from city center
The price is $76 per night
$76
per night
Dec 10 - Dec 11
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport shuttle. Guests will appreciate freebies like continental breakfast and free self parking.
Pool
Free WiFi
My Place Hotel - Greenville, SC

My Place Hotel - Greenville, SC

2.5 out of 5
11 Ketron Court, Greenville, SC, 29607
Free Cancellation
Reserve now, pay when you stay
4.72 mi from city center
The price is $77 per night
$77
per night
Dec 26 - Dec 27
Free WiFi in public areas, a garden, and a picnic area are available at this hotel. Traveling on business? Take advantage of the 24-hour business center and free Internet in public areas. Dry cleaning, luggage storage, and laundry facilities are also on offer.
Free WiFi
Pet friendly
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See all available properties in Upstate South Carolina
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top family friendly Upstate South Carolina hotel deals

  • Best Western Greenville Airport Inn

    Best Western Greenville Airport Inn

    5009 Pelham Road, Greenville, SC, 29615-5465
    The price is $76 per night from Dec 10 to Dec 11
    $76
    per night
    Dec 10 - Dec 11
    3.8/5 Good! (1,000 reviews)

Top cheap Upstate South Carolina hotel deals

  • Baymont by Wyndham Anderson Clemson

    Baymont by Wyndham Anderson Clemson

    128 Interstate Blvd, Anderson, SC, 29621-2319
    The price is $59 per night from Dec 11 to Dec 12
    $59
    per night
    Dec 11 - Dec 12
    3.5/5 Good! (617 reviews)

Top hotels in Upstate South Carolina for Extended Stay

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Seize your some day

Cheap Hotels in Upstate South Carolina

Pack your bags—it’s time to embark on a getaway. Whether you’re craving a solo retreat or promising your family a vacation to remember, book one of the best hotels in Upstate South Carolina. These hotels are located within easy access of the city’s hottest attractions and entertainment, so you won’t miss a beat while you’re in town. Spend the days exploring the local landmarks and the evenings getting to know the nightlife. After exploring the city from top to bottom, rest up at a hotel that speaks to you. Find the perfect place that matches your trip’s vibe, from a trendy boutique to family-friendly accommodations.

Allow us here at Travelocity to pair you with up Upstate South Carolina hotels that suit your vacation preferences. Discover places with convenient on-site restaurants, around-the-clock service, and pools where your kids can make a splash. Some hotels may boast fitness rooms and spa services, while others feature game rooms and Wi-Fi access. To top it all off, you’ll score cheap hotels in Upstate South Carolina that let you spend more on your activities and less on your lodging. Book and bundle your flight and hotel deals together today and save $$$. It’s time to explore a new city, and break out of your routine.

Recent Upstate South Carolina hotel reviews by fellow wanderers

  • Hyatt Place Greenville/Downtown

    Hyatt Place Greenville/Downtown

    5 out of 5
    Posted 2 days ago
    travelocity Verified Review
    "Hotel is very well located. Near all points of interest in Downtown area. Pool was fantastic. Would definitely stay here again. "
    A verified traveler stayed at Hyatt Place Greenville/Downtown
    Hyatt Place Greenville/Downtown