Book Hotels in Upstate South Carolina, SC
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Top Upstate South Carolina hotels
Hotel Hartness
120 Halston Avenue Greenville SC
Fully refundableReserve now, pay when you stay
$208 nightly
The price is $228 total per night from Oct 4 to Oct 5
$228 total
Oct 4 - Oct 5
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...
"Great place and vibe!"
Reviewed on Sep 28, 2026
Grand Bohemian Lodge Greenville, Autograph Collection
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$401 nightly
The price is $441 total per night from Oct 4 to Oct 5
$441 total
Oct 4 - Oct 5
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
"Perfect property"
Reviewed on Sep 28, 2026
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
$99 nightly
The price is $110 total per night from Oct 18 to Oct 19
$110 total
Oct 18 - Oct 19
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"clean room"
Reviewed on Sep 28, 2026
Hyatt Place Greenville/Haywood
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $91 total per night from Oct 18 to Oct 19
$91 total
Oct 18 - Oct 19
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"I was grateful to have a place to stay for the night but they were in the middle of extensive renovations. Not safe (there was construction equipment out and about, trip hazards, etc), not quiet, and only one elevator that was barely working for the whole building. They should close the hotel for ..."
Reviewed on Sep 25, 2026
Hilton Greenville
45 W Orchard Park Dr Greenville SC
$117 nightly
The price is $129 total per night from Oct 11 to Oct 12
$129 total
Oct 11 - Oct 12
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$108 nightly
The price is $120 total per night from Oct 4 to Oct 5
$120 total
Oct 4 - Oct 5
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Best Western Plus Greenville I-385 Inn & Suites
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $84 total per night from Oct 18 to Oct 19
$84 total
Oct 18 - Oct 19
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Mint House Greenville Downtown by Kasa
101 Falls Park Dr Greenville SC
$145 nightly
The price is $160 total per night from Oct 4 to Oct 5
$160 total
Oct 4 - Oct 5
Total with taxes and fees
A 24-hour gym, self parking, and laundry facilities are featured at this apartment. Express check-in and express check-out are also provided.
Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $117 total per night from Oct 4 to Oct 5
$117 total
Oct 4 - Oct 5
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
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See all available properties in Upstate South Carolina
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cheap Upstate South Carolina hotels
Baymont by Wyndham Anderson Clemson
128 Interstate Blvd Anderson SC
$64 nightly
The price is $71 total per night from Oct 6 to Oct 7
$71 total
Oct 6 - Oct 7
Total with taxes and fees
7/10 Good! (920 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Upstate South Carolina with star-rating
Check Upstate South Carolina Hotels by Star Rating
4 Star Hotels
34 properties
Recent Upstate South Carolina hotel reviews by fellow wanderers
Hotel Hartness
5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Great place and vibe!"
A verified traveler stayed at Hotel Hartness
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