Book Hotels in Upstate South Carolina, SC

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Top Upstate South Carolina hotels

Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson SC
Free WiFi in public areas is available at this cottage.
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Opens in a new windowWooded Cottage - 3 Mi to Clemson University
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$278 nightly
The price is $306 total per night from Dec 14 to Dec 15
$306 total
Dec 14 - Dec 15
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...
great service

Reviewed on Nov 16, 2025

Opens in a new windowGrand Bohemian Lodge Greenville, Autograph Collection
Homewood Suites by Hilton Greenville Downtown

Homewood Suites by Hilton Greenville Downtown

3 out of 5
950 South Main Street Greenville SC
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $98 total per night from Dec 24 to Dec 25
$98 total
Dec 24 - Dec 25
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Everything was first class. Individual attention to special needs and a smiling desk attendant and some flexibility with check in. Guy named Kenny was very helpful. It's nice to see people go the extra mile.

Reviewed on Nov 27, 2025

Opens in a new windowHomewood Suites by Hilton Greenville Downtown
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $115 total per night from Dec 19 to Dec 20
$115 total
Dec 19 - Dec 20
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Smooth and perfect. Queen Suite is par excellence. Neat clean and all in place and more than what was expected.

Reviewed on Nov 27, 2025

Opens in a new windowBest Western Plus Greenville I-385 Inn & Suites
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

3.5 out of 5
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $101 total per night from Dec 7 to Dec 8
$101 total
Dec 7 - Dec 8
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Love the corner room. So large

Reviewed on Nov 27, 2025

Opens in a new windowEmbassy Suites Greenville Golf Resort & Conference Center
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$140 nightly
The price is $153 total per night from Dec 21 to Dec 22
$153 total
Dec 21 - Dec 22
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
They did a wonderful job everything was great!!!

Reviewed on Nov 24, 2025

Opens in a new windowHyatt Regency Greenville
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

3 out of 5
11 Ketron Court Greenville SC
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $104 total per night from Dec 14 to Dec 15
$104 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free breakfast and free WiFi. Traveling on business? Take advantage of the 24-hour business center and ...
I was very relieved when i walked in the lobby. It was clean and the staff was very helpful and polite. I even stayed a second night!

Reviewed on Nov 15, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $110 total per night from Dec 14 to Dec 15
$110 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
Room was great. Joe at check in was more than helpful.

Reviewed on Nov 24, 2025

Opens in a new windowHilton Greenville
Hyatt Place Greenville/Haywood

Hyatt Place Greenville/Haywood

3 out of 5
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $89 total per night from Dec 29 to Dec 30
$89 total
Dec 29 - Dec 30
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
While the room was acceptable, there was quite a bit of dirt on the floor. Also, the ice bucket and glasses were dirty. We had to go downstairs to get clean ones. Also the soap dispenser in the shower was enptu

Reviewed on Nov 28, 2025

Opens in a new windowHyatt Place Greenville/Haywood
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Upstate South Carolina hotels

Baymont by Wyndham Anderson Clemson

Baymont by Wyndham Anderson Clemson

128 Interstate Blvd Anderson SC
$60 nightly
The price is $66 total per night from Dec 8 to Dec 9
$66 total
Dec 8 - Dec 9
Total with taxes and fees
7/10 Good! (838 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Upstate South Carolina hotel reviews by fellow wanderers

Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

5 out of 5
Posted 4 days ago
Travelocity Verified Review
"Smooth and perfect. Queen Suite is par excellence. Neat clean and all in place and more than what was expected. "
A verified traveler stayed at Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & Suites

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