Book Hotels in Upstate South Carolina, SC
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Top Upstate South Carolina hotels
Hotel Hartness
120 Halston Avenue Greenville SC
$208 nightly
The price is $228 total per night from Oct 4 to Oct 5
$228 total
Oct 4 - Oct 5
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...
"Impeccable."
Reviewed on Sep 13, 2026
Grand Bohemian Lodge Greenville, Autograph Collection
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$361 nightly
The price is $397 total per night from Oct 4 to Oct 5
$397 total
Oct 4 - Oct 5
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
"Room was not ready. Check in said 4:00 but we had to wait a long time and they couldn’t tell us when our room would be ready."
Reviewed on Sep 12, 2026
Best Western Plus Greenville I-385 Inn & Suites
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $84 total per night from Oct 4 to Oct 5
$84 total
Oct 4 - Oct 5
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Clean, comfortable! Will definitely be back"
Reviewed on Sep 13, 2026
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $93 total per night from Sep 20 to Sep 21
$93 total
Sep 20 - Sep 21
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"I am more than happy to use my towels over but please provide towel racks."
Reviewed on Sep 13, 2026
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $116 total per night from Sep 20 to Sep 21
$116 total
Sep 20 - Sep 21
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Hilton Greenville
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$117 nightly
The price is $129 total per night from Sep 20 to Sep 21
$129 total
Sep 20 - Sep 21
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
Hyatt Regency Greenville
220 N Main St Greenville SC
$157 nightly
The price is $172 total per night from Sep 27 to Sep 28
$172 total
Sep 27 - Sep 28
Total with taxes and fees
This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $112 total per night from Sep 16 to Sep 17
$112 total
Sep 16 - Sep 17
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Days Inn by Wyndham Greenville
60 Roper Mountain Rd Greenville SC
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $66 total per night from Sep 20 to Sep 21
$66 total
Sep 20 - Sep 21
Total with taxes and fees
This motel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...
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See all available properties in Upstate South Carolina
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cheap Upstate South Carolina hotels
Baymont by Wyndham Anderson Clemson
128 Interstate Blvd Anderson SC
$64 nightly
The price is $71 total per night from Oct 11 to Oct 12
$71 total
Oct 11 - Oct 12
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Upstate South Carolina with star-rating
Check Upstate South Carolina Hotels by Star Rating
4 Star Hotels
34 properties
Recent Upstate South Carolina hotel reviews by fellow wanderers
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
4 out of 5
Posted less than an hour ago
Travelocity Verified Review
"I am more than happy to use my towels over but please provide towel racks."
A verified traveler stayed at Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
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