Book Hotels in Upstate South Carolina, SC

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Top Upstate South Carolina hotels

Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson SC
Free WiFi in public areas is available at this cottage.
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Opens in a new windowWooded Cottage - 3 Mi to Clemson University
Homewood Suites by Hilton Greenville Downtown

Homewood Suites by Hilton Greenville Downtown

3 out of 5
950 South Main Street Greenville SC
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $135 total per night from Dec 21 to Dec 22
$135 total
Dec 21 - Dec 22
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Great room and nice staff

Reviewed on Dec 3, 2025

Opens in a new windowHomewood Suites by Hilton Greenville Downtown
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$295 nightly
The price is $324 total per night from Jan 4 to Jan 5
$324 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...
great service

Reviewed on Nov 16, 2025

Opens in a new windowGrand Bohemian Lodge Greenville, Autograph Collection
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $115 total per night from Dec 19 to Dec 20
$115 total
Dec 19 - Dec 20
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
yes

Reviewed on Dec 5, 2025

Opens in a new windowBest Western Plus Greenville I-385 Inn & Suites
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

3.5 out of 5
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $101 total per night from Dec 14 to Dec 15
$101 total
Dec 14 - Dec 15
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Good

Reviewed on Dec 2, 2025

Opens in a new windowEmbassy Suites Greenville Golf Resort & Conference Center
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

3 out of 5
11 Ketron Court Greenville SC
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $100 total per night from Dec 9 to Dec 10
$100 total
Dec 9 - Dec 10
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free breakfast and free WiFi. Traveling on business? Take advantage of the 24-hour business center and ...
I'm Happy

Reviewed on Nov 30, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
851 Congaree Rd Greenville SC
Fully refundable
$87 nightly
The price is $96 total per night from Dec 14 to Dec 15
$96 total
Dec 14 - Dec 15
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Overall was fine. Can’t blame the hotel for the clientele, but one room was making the hall reek of weed. To the hotel’s credit they sent someone right away to deal with the issue. The room was comfortable.

Reviewed on Nov 28, 2025

Opens in a new windowCrowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $110 total per night from Dec 14 to Dec 15
$110 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
Can use a little updating but overall good location.

Reviewed on Dec 5, 2025

Opens in a new windowHilton Greenville
ECHO Suites Extended Stay by Wyndham Spartanburg

ECHO Suites Extended Stay by Wyndham Spartanburg

2 out of 5
490 W Blackstock Road Spartanburg SC
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $84 total per night from Dec 9 to Dec 10
$84 total
Dec 9 - Dec 10
Total with taxes and fees
A 24-hour gym, free self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Staff at the 24-hour front desk can provide ...
Nice hotel

Reviewed on Dec 2, 2025

Opens in a new windowECHO Suites Extended Stay by Wyndham Spartanburg
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Upstate South Carolina hotels

Baymont by Wyndham Anderson Clemson

Baymont by Wyndham Anderson Clemson

128 Interstate Blvd Anderson SC
$64 nightly
The price is $71 total per night from Dec 14 to Dec 15
$71 total
Dec 14 - Dec 15
Total with taxes and fees
7/10 Good! (839 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Upstate South Carolina hotel reviews by fellow wanderers

Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"yes"
A verified traveler stayed at Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & Suites

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