Book Hotels in Upstate South Carolina, SC
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Top Upstate South Carolina hotels
Wooded Cottage - 3 Mi to Clemson University
Clemson
Free WiFi in public areas is available at this cottage. Take advantage of the free self parking.
Grand Bohemian Lodge Greenville, Autograph Collection
44 EAST CAMPERDOWN WAY, Greenville, SC
Fully refundableReserve now, pay when you stay
$267 nightly
The price is $294 total per night from Oct 26 to Oct 27
$294 total
Oct 26 - Oct 27
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...
"What a fabulous hotel. Great location, super clean, and the most helpful staff."
Reviewed on Sep 29, 2025
Hyatt Place Greenville Downtown
128 East Broad Street, Greenville, SC
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $149 total per night from Nov 2 to Nov 3
$149 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Wonderful stay!
"From the moment we arrived until we left the staff was very customer service oriented. Was willing to share and always had a smile!"
Reviewed on Sep 29, 2025
Best Western Plus Greenville I-385 Inn & Suites
831 Congaree Rd, Greenville, SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $92 total per night from Oct 5 to Oct 6
$92 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Always very good stay. They have some construction going on with the elevator though"
Reviewed on Sep 30, 2025
Courtyard by Marriott Greenville Haywood Mall
70 Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $121 total per night from Oct 12 to Oct 13
$121 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
"Small pet friendly."
Reviewed on Sep 9, 2025
Hyatt Regency Greenville
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
$166 nightly
The price is $182 total per night from Oct 12 to Oct 13
$182 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"The Hyatt was in the center of eveything that is going on. Staff was very kind and very helpfull and so many good restaurants in walking distance and well night life. Highly recommend staying at the Hyatt Regency!"
Reviewed on Sep 29, 2025
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd, Greenville, SC
Fully refundable
$95 nightly
The price is $105 total per night from Oct 5 to Oct 6
$105 total
Oct 5 - Oct 6
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Check in was very smooth and staff were very friendly. The room was nice bed was comfortable. We had a wonderful dinner in the Ruth Chris restaurant!"
Reviewed on Sep 29, 2025
Hilton Greenville
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $114 total per night from Oct 5 to Oct 6
$114 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
"Very nice"
Reviewed on Sep 30, 2025
La Quinta Inn & Suites by Wyndham Greenville Haywood
65 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $73 total per night from Oct 5 to Oct 6
$73 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. ...
"Clean room, nice staff, and convenient location."
Reviewed on Oct 1, 2025
Don't see what you're looking for?
See all available properties in Upstate South Carolina
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cheap Upstate South Carolina hotels
Baymont by Wyndham Anderson Clemson
128 Interstate Blvd, Anderson, SC
$68 nightly
The price is $75 total per night from Oct 12 to Oct 13
$75 total
Oct 12 - Oct 13
Total with taxes and fees
6.8/10 (818 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Upstate South Carolina with star-rating
Check Upstate South Carolina Hotels by Star Rating
4 Star Hotels
14 properties
Recent Upstate South Carolina hotel reviews by fellow wanderers
La Quinta Inn & Suites by Wyndham Greenville Haywood
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Clean room, nice staff, and convenient location. "
A verified traveler stayed at La Quinta Inn & Suites by Wyndham Greenville Haywood
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