Book Hotels in Seneca, SC
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top Seneca hotels
Postcard Cabins Lake Hartwell
Reviewed on Jul 5, 2025
Fairfield Inn & Suites Seneca Clemson Univ Area
Reviewed on Jul 6, 2025
Incredible 10 BR home with pool
Reviewed on Jun 1, 2025
Hampton Inn & Suites Seneca-Clemson Area
Reviewed on Jun 30, 2025
Tru by Hilton Seneca Clemson
Reviewed on Jun 19, 2025
Lakeside Lodge Clemson
Reviewed on Jul 7, 2025
Best Western Seneca-Clemson
Reviewed on Jun 15, 2025
Quality Inn Seneca Clemson Area US-123
Reviewed on Jun 22, 2025
Days Inn by Wyndham Seneca / Clemson Area
Reviewed on Jun 26, 2025
Cheap Seneca hotels
Days Inn by Wyndham Seneca / Clemson Area
Seneca Hotel & Travel Guide
Wandering through Anderson? If you're looking to get a feel of the city, research places to base you adventure which are within a short drive from the excitement of Seneca. Within a 6-mile (10-kilometer) distance from central Seneca, you will find 4 suitable hotel and apartment options.
If you're seeking out a room within a short walk from the center of Seneca, Hampton Inn & Suites Seneca-Clemson Area and Best Western Executive Inn are ideal.
Our extensive database contains only a handful of no-frills accommodations in Seneca. The Quality Inn Seneca / Clemson is one such listing.
Look into the Hampton Inn Clemson and also the Liberty Hall Inn & Brandinis Cusine. The Hampton Inn Clemson is situated just 6 miles (10 kilometers) outside of the city center of Seneca. The Liberty Hall Inn & Brandinis Cusine, is located just 10 miles (16 kilometers) away. Other hotel options are the Holiday Inn Express Hotel & Suites Anderson-I-85 and the Holiday Inn Express & Suites Clemson.
Anyone who is excited to check out more of the rolling hills and foothills typical in this region of the country, you should make time for a few extra days in other destinations in Upstate South Carolina. It doesn't matter if you throw yourself at traditional pastimes, like mountain biking and hiking, or skip around the area to explore the attractions, you'll easily reserve the most comfortable hotels in the area.
The nearest hotels in Anderson are Clemson and Clemson. Clemson is 8 miles (12 kilometers) to the east of Seneca, while Clemson is 8 miles (12 kilometers) to the east. Clemson Travelocity-listed lodgings are the Courtyard Marriott Clemson and University Inn & Conference Center at Clemson. The Hotel Tillman and Days Inn Clemson are a selection of the hotel options in Clemson.
When watching stadium sport is your most-cherished pastime, visit Bon Secours Wellness Arena, which you will find 35 miles (55 kilometers) to the east of Seneca. Book Travelocity-listed accommodation near the action at the Courtyard by Marriott Greenville Downtown or the Hampton Inn & Suites Greenville Downtown RiverPlace.
If you are flying via Greenville-Spartanburg International Airport and want to book a Travelocity-listed hotel in the area, consider Greenville Marriott or Courtyard Greenville-Spartanburg by Marriott.
Top reasons for your vacation to Seneca
- Outdoor Activities: Seneca offers a variety of outdoor activities perfect for a family vacation. Explore the beautiful scenery, enjoy boating on the nearby lake, and engage in thrilling sports activities.
- Local University: Visit the local university area, filled with youthful energy and vibrant vibes. Take a campus tour and experience the lively atmosphere.
- Friendly Atmosphere: Seneca is known for its friendly people and welcoming atmosphere. Residents greet you with smiles and helpful nature, ensuring a memorable stay.
- Escape Rooms: Try the escape rooms in town for a unique and exciting experience. Challenge your family to solve puzzles and enjoy the thrill of escaping.
- Scenic Charm: Relax and enjoy the scenic charm of Seneca while sipping a cup of coffee. Take in the beautiful landscapes and immerse yourself in the peaceful ambiance.
Find your favorite hotels in Seneca
If you're planning an outdoor vacation in Seneca, South Carolina, you'll find a range of hotel accommodations to choose from. Whether you're looking for a budget-friendly option or a more luxurious stay, there are plenty of choices available. Most hotels in Seneca offer comfortable rooms and convenient amenities, making them a great choice for families. With a variety of cheap hotels in Seneca, you can find accommodation that fits your budget without sacrificing quality.
| Hotel name | Type | Stars | Description |
| Lakeside Lodge Clemson | Hotel | 2.5 | This 2.5-star rated hotel offers a serene lakeside location, perfect for outdoor enthusiasts. With its close proximity to nature trails and fishing spots, it is an ideal choice for your outdoor vacation in Seneca, South Carolina. The hotel also provides convenient facilities such as an outdoor pool and comfortable rooms, ensuring a relaxing stay for you and your family. |
| Tru by Hilton Seneca Clemson | Hotel | 2.5 | Another 2.5-star rated hotel option, Tru by Hilton Seneca Clemson, offers a contemporary and vibrant atmosphere. Its location is convenient for outdoor activities, with nearby hiking trails and parks. The hotel boasts modern amenities and comfortable rooms, providing a refreshing stay for your outdoor vacation. |
| Quality Inn Seneca US-123 | Hotel | 2.5 | This 2.5-star rated hotel stands out for its wide range of accessible facilities, including connecting rooms, an outdoor pool, and a pet-friendly policy. Its proximity to waterfalls and outdoor excursions makes it an excellent choice for an outdoor vacation in Seneca. Additionally, the hotel offers free breakfast and is known for its family-friendly environment. |
Explore the best activities and sights in Seneca
Seneca, South Carolina offers a variety of outdoor activities perfect for a family vacation. Explore the beautiful scenery and enjoy boating on the nearby lake. Engage in sports activities such as football or visit the local university for a campus tour. Take advantage of the family-friendly marina and campground area for a fun-filled stay. For a unique experience, try the escape rooms in town. Seneca is known for its friendly people and welcoming atmosphere. Don't forget to relax and enjoy a cup of coffee while taking in the charm of this scenic destination.
- Busch Gardens Tampa Bay: Busch Gardens Tampa Bay is a captivating theme park that offers a thrilling and immersive experience. Explore the beautiful gardens and be amazed by the variety of thrilling rides and attractions. Indulge in delicious dining options and shop for unique souvenirs. Enjoy live music performances and get up close and personal with the incredible animals at the zoo. With its family-friendly atmosphere, festivals, and theater shows, Busch Gardens Tampa Bay guarantees a memorable and entertaining experience for visitors of all ages.
- Great Smoky Mountains National Park: Great Smoky Mountains National Park is a breathtaking national state park that showcases the majestic beauty of mountains and nature. Embark on an exhilarating hiking adventure and soak in the panoramic views. Immerse yourself in the tranquil atmosphere of the park's rivers and waterfalls. For a touch of excitement, visit the nearby casino. Great Smoky Mountains National Park offers a perfect blend of adventure, stunning scenery, and outdoor activities that cater to nature enthusiasts and adventure seekers alike.
- Biltmore Estate: Biltmore Estate is a magnificent historic house that offers a rich cultural experience. Enjoy live music performances and theater shows amidst the stunning mountain backdrop. Wander through the beautifully manicured gardens and marvel at the colorful array of flowers. Immerse yourself in art and cultural festivals that celebrate the estate's heritage. For a unique experience, try horseback riding and take informative tours. Biltmore Estate is a must-visit destination for those seeking to immerse themselves in history, culture, and natural beauty.
Where to stay in Seneca
Get ready for a thrilling outdoor vacation in Seneca, South Carolina! This charming city boasts a warm and friendly atmosphere, making it a perfect destination for families. Explore the beautiful landscapes and stunning scenery as you engage in thrilling sports activities. Don't miss the chance to visit the local university area, which is filled with youthful energy and vibrant vibes. Seneca residents are known for their welcoming smiles and helpful nature, ensuring that your stay is memorable. If you're in the mood for a romantic getaway, nearby cities offer a peaceful and serene ambiance. Get ready for an unforgettable adventure in Seneca!
- Pine Ridge Point: Pine Ridge Point is a charming neighborhood in Seneca, South Carolina. Nestled amidst lush greenery and stunning landscapes, it offers a unique outdoor experience for families. You can enjoy activities like hiking, fishing, and boating in the nearby Lake Keowee. The neighborhood also has several parks and picnic spots where you can relax and have a great time with your family. Pine Ridge Point is known for its friendly locals and warm atmosphere, making it an ideal destination for a peaceful and rejuvenating outdoor vacation.
- Serenity Bay: Serenity Bay is a picturesque neighborhood in Seneca, South Carolina. As the name suggests, it offers a serene and tranquil atmosphere for families seeking a peaceful outdoor vacation. Surrounded by beautiful lakes and forests, Serenity Bay is perfect for activities like kayaking, paddleboarding, and nature walks. You can also enjoy picnics by the lakeside or simply soak in the breathtaking views. The neighborhood's peaceful ambiance and natural beauty make it a must-visit destination for a relaxing outdoor vacation with your family.
- Keowee Plantation: Keowee Plantation is a popular neighborhood known for its natural beauty and outdoor recreational opportunities. Located near Lake Keowee, it offers a range of water activities such as swimming, fishing, and boating. The neighborhood also has well-maintained hiking trails where you can explore the surrounding forests and enjoy stunning views. Keowee Plantation has a welcoming community and a laid-back atmosphere, making it an ideal destination for a fun-filled outdoor vacation with your family.
The travel seasons of Seneca
Trips to Seneca show no change in popularity throughout the year. The peak season to visit is from July to September, with September being the highest month. Off-peak season starts from October to December, and December sees the least travelers.
Seneca has something in store for you whenever you visit. January is the coldest month of the year, while July is hottest, with average temperatures up to 79.2 degrees Fahrenheit. The wettest month in Seneca is December, so pack accordingly.
 Calendar Month |  Temperature |  Precipitation |  Cloudiness |
| January | 41.7°F (5.4°C) | Light Rain | Mostly Sunny |
| February | 45.7°F (7.6°C) | Light Rain | Mostly Sunny |
| March | 52.0°F (11.1°C) | Light Rain | Mostly Sunny |
| April | 59.9°F (15.5°C) | Light Rain | Mostly Sunny |
| May | 68.2°F (20.1°C) | Light Rain | Mostly Sunny |
| June | 75.7°F (24.3°C) | Light Rain | Mostly Sunny |
| July | 79.2°F (26.2°C) | Light Rain | Mostly Sunny |
| August | 77.4°F (25.2°C) | Light Rain | Mostly Sunny |
| September | 72.1°F (22.3°C) | Light Rain | Mostly Sunny |
| October | 62.1°F (16.7°C) | Light Rain | Mostly Sunny |
| November | 51.4°F (10.8°C) | Light Rain | Mostly Sunny |
| December | 45.7°F (7.6°C) | Light Rain | Mostly Sunny |
Food and dining in Seneca
When visiting Seneca, South Carolina, you'll find a variety of local cuisines to satisfy your food cravings. One popular option is Applebee's, a moderately rated and highly popular restaurant that serves North American dishes. If you're in the mood for Latin American Mexican cuisine, head to Los Amigos, a highly rated and highly popular restaurant. For Asian Chinese dishes, China Wok is a moderately rated and highly popular choice. Whether you're looking for an on-site restaurant or good dining options, Seneca has something for everyone. Additionally, there are coffee shops in Seneca and bars in nearby Clemson to enjoy. Dining costs vary depending on the restaurant and menu selection.
How do I find a great hotel with Travelocity?
Ensure your entire crew has a memorable vacation with our reliable online travel platform. Discover the ideal accommodations by using our family-friendly badge, which highlights hotels offering extra amenities for children. Our custom filters allow you to narrow down options to hotels closest to top attractions, providing enhanced cleaning services, all within your budget range.
Why should I book with Travelocity?
Conference calls, to-do lists and, of course, football practice. Busy lives and packed schedules call for trips that are hassle-free. Our aim is to provide stress-free travel every time you and your family book with us so that you can spend less time worrying and more time creating cherished memories. To achieve this, we will assist you in finding and planning your perfect trip, as well as provide transparent pricing, reliable reviews, and 24/7 guaranteed customer support before, during, and after your vacation.
How can I save money on my trip to Seneca?
To save money on your trip to Seneca, consider visiting during the less popular season from October to December. By bundling your flights, hotel, and car bookings together, you can get a discounted price. While in Seneca, take advantage of the local affinities that are inexpensive. Explore the beautiful scenery and enjoy boating on the nearby lake. Visit the family-friendly marina and interact with the friendly locals. These activities will provide affordable entertainment for your family.
Frequently asked questions
Recent Seneca hotel reviews by fellow wanderers
Lakeside Lodge Clemson
Explore More Ways to Travel with Travelocity
Accommodation Types
Accommodation Types in Seneca
- Hotels on the Lake in Seneca
- Kid Friendly Hotels in Seneca
- Hotels with Restaurants in Seneca
- Hotels with Shopping in Seneca
- Hotels with Pools in Seneca
- Romantic Getaways & Hotels in Seneca
- Hotels with Balconies in Seneca
- Convention Center Hotels in Seneca
- Hotels with Free Breakfast in Seneca
- Pet Friendly Hotels in Seneca
- Cheap Hotels in Seneca
- Hotels with a Gym in Seneca
- Hotels with Hot Tubs in Seneca
- Ski Resorts and Hotels in Seneca
- Hotels with Bar in Seneca
- Golf Resorts & Hotels in Seneca
- Hotel Wedding Venues in Seneca
- Spa Resorts & Hotels in Seneca
- Hotels with smoking rooms in Seneca
- Beach Resorts & Hotels in Seneca
- Luxury Hotels in Seneca
- Highlands Hotels
- North Georgia Mountains Hotels
- Brevard Hotels
- North Carolina Mountains Hotels
- Anderson Hotels
- Cashiers Hotels
- Clemson Hotels
- Blue Ridge Mountains Hotels
- Clayton Hotels
- Tiger Hotels
- Sapphire Hotels
- Lake Toxaway Hotels
- Salem Hotels
- Toccoa Hotels
- Clarkesville Hotels
- Dillard Hotels
- Easley Hotels
- Hartwell Hotels
- Central Hotels
- Sunset Hotels
- Lakemont Hotels
- Lavonia Hotels
- Cleveland Hotels
- Mountain Rest Hotels
- Appalachian Mountains Hotels
- Townville Hotels
- Six Mile Hotels
- Fair Play Hotels
- Pickens Hotels
- Elberton Hotels
- Southeastern United States Hotels
- Westminster Hotels
- Piedmont Hotels
- Walhalla Hotels
- The Carolinas Hotels
- Pendleton Hotels
- Reed Creek Hotels
- Northeast Georgia Hotels
- Greenville - Spartanburg Hotels
- West Union Hotels