Explore top 2026 4 Star Hotels in Upstate South Carolina

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Top Upstate South Carolina 4 Star hotels

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$339 nightly
The price is $372 total per night from May 3 to May 4
$372 total
May 3 - May 4
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.6/10 Exceptional! (483 reviews)
Clean room.

Reviewed on Apr 22, 2026

Opens in a new windowGrand Bohemian Lodge Greenville, Autograph Collection
Hotel Hartness

Hotel Hartness

4 out of 5
120 Halston Avenue Greenville SC
Fully refundableReserve now, pay when you stay
$209 nightly
The price is $230 total per night from May 27 to May 28
$230 total
May 27 - May 28
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...
9.8/10 Exceptional! (713 reviews)
Our anniversary trip to this hotel was FABULOUS! Special thanks to Ciara, the Bartender. She was kind and gave excellent suggestions regarding different liquors and food tastings. Rashad, at the front desk, was funny and very friendly. Everyone that we encountered went out of their way to be helpful ...

Reviewed on Apr 29, 2026

Opens in a new windowHotel Hartness
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St Clemson SC
Fully refundableReserve now, pay when you stay
$199 nightly
The price is $221 total per night from May 10 to May 11
$221 total
May 10 - May 11
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also ...
9.8/10 Exceptional! (793 reviews)
Beautiful hotel conveniently located next to Clemson University. Highly recommend!!

Reviewed on Apr 27, 2026

Opens in a new windowThe Shepherd Hotel Downtown Clemson
Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa

4 out of 5
101 Falls Park Dr Greenville SC
$102 nightly
The price is $112 total per night from May 18 to May 19
$112 total
May 18 - May 19
Total with taxes and fees
A 24-hour gym, self parking, and laundry facilities are featured at this apartment. Express check-in and express check-out are also provided.
9.2/10 Wonderful! (820 reviews)
Never got check-in instructions. Way too much time spent dorking around st front door trying to get set Parking not clearly marked. For check out say the elevators did not respond to call buttons Good price, nice room but the overall experience was terrible. Kasa / Mint House just dropped the ball ...

Reviewed on Apr 29, 2026

Opens in a new windowMint House Greenville Downtown by Kasa
The Westin Poinsett Greenville

The Westin Poinsett Greenville

4 out of 5
120 South Main St Greenville SC
Fully refundableReserve now, pay when you stay
$202 nightly
The price is $222 total per night from May 17 to May 18
$222 total
May 17 - May 18
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free ...
9.2/10 Wonderful! (1,001 reviews)
The hotel has an understated elegance - historical, lovely, but not stuffy or “over the top.” We stayed in a junior suite which was generously sized and had a very comfortable sofa and arm chair. One of the things we enjoyed most was the piano music every evening at 5:30, except for Sundays. Very ...

Reviewed on Apr 30, 2026

Opens in a new windowThe Westin Poinsett Greenville
Greenville Marriott

Greenville Marriott

4 out of 5
One Parkway E Greenville SC
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $145 total per night from May 17 to May 18
$145 total
May 17 - May 18
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-in, ...
8.6/10 Excellent! (647 reviews)
Shannon is amazing!!

Reviewed on Apr 30, 2026

Opens in a new windowGreenville Marriott
The Abernathy of Clemson

The Abernathy of Clemson

4 out of 5
157 Old Greenville Hwy Clemson SC
Fully refundableReserve now, pay when you stay
$164 nightly
The price is $182 total per night from May 18 to May 19
$182 total
May 18 - May 19
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...
9.6/10 Exceptional! (594 reviews)
Easy parking, great location. Will stay there again

Reviewed on Apr 24, 2026

Opens in a new windowThe Abernathy of Clemson
Doubletree By Hilton Greenville Airport

Doubletree By Hilton Greenville Airport

4 out of 5
125 The Parkway Greer SC
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $139 total per night from Jun 1 to Jun 2
$139 total
Jun 1 - Jun 2
Total with taxes and fees
A 24-hour gym is available at this hotel. Take advantage of the free self parking.
10/10 Exceptional! (2 reviews)
This work trip was last minute and no hotels were available. This one popped up and I was nervous bc I had never seen it before. That’s because it had only been open 4 days! I couldn’t believe my luck. It was perfect! Perfect food! Perfect hospitality! Perfect room!

Reviewed on Mar 23, 2026

Opens in a new windowDoubletree By Hilton Greenville Airport
The Station by Compo Hotels

The Station by Compo Hotels

4 out of 5
745 Old Buncombe Rd Travelers Rest SC
$361 nightly
The price is $397 total per night from May 4 to May 5
$397 total
May 4 - May 5
Total with taxes and fees
This aparthotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Barbecue grills are provided for your convenience.
10/10 Exceptional! (19 reviews)
Swamp rabbit trail and restaurants very close

Reviewed on Apr 2, 2026

Opens in a new windowThe Station by Compo Hotels
Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast

4 out of 5
621 S Mechanic St Pendleton SC
$176 nightly
The price is $195 total per night from May 9 to May 10
$195 total
May 9 - May 10
Total with taxes and fees
This bed & breakfast features free WiFi in public areas, concierge services, and free self parking. Enjoy the free full breakfast each morning. A garden, express ...
10/10 Exceptional! (88 reviews)
Such a great getaway! My room was clean and breakfast the next morning was absolutely delicious. The porches were such great relaxing spots as well during my stay, can’t wait to return!!

Reviewed on Apr 28, 2026

Opens in a new windowLiberty Hall Bed and Breakfast
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4 Star Hotels Upstate South Carolina

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Upstate South Carolina 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Upstate South Carolina will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Upstate South Carolina, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Upstate South Carolina hotel reviews by fellow wanderers

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