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Most frequently booked South Main hotels

$85
Comfort Suites near Texas Medical Center - NRG Stadium

Comfort Suites near Texas Medical Center - NRG Stadium

2.5 out of 5.0 1055 Mcnee Rd, Houston, TX
4.2/5
(4 Reviews)
This hotel features a fitness center and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like full breakfast and free self parking.
 
$81
Crowne Plaza Hotel Houston near Reliant - Medical

Crowne Plaza Hotel Houston near Reliant - Medical

3.5 out of 5.0 8686 Kirby Drive, Houston, TX
3.5/5
(17 Reviews)
2 outdoor pools, a 24-hour fitness center, and a spa tub are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 15 conference rooms, as well as the 24-hour business center and free WiFi in public areas. Enjoy a meal from the a restaurant and perks like free self parking.
 
$59
Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center

2.5 out of 5.0 2364 South Loop W, Houston, TX
2.8/5
(15 Reviews)
This hotel features an outdoor pool and a fitness center. Families will appreciate the children's pool and onsite laundry facilities. Free perks include on-the-go breakfast, free self parking, and an area shuttle.
 
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How much is a hotel room in South Main?

Hotels in South Main start at $59 per night. Prices and availability subject to change. Additional terms may apply.

Cheap Hotels in South Main

Pack your bags—it’s time to embark on a getaway. Whether you’re craving a solo retreat or promising your family a vacation to remember, book one of the best hotels in South Main. These hotels are located within easy access of the city’s hottest attractions and entertainment, so you won’t miss a beat while you’re in town. Spend the days exploring the local landmarks and the evenings getting to know the nightlife. After exploring the city from top to bottom, rest up at a hotel that speaks to you. Find the perfect place that matches your trip’s vibe, from a trendy boutique to family-friendly accommodations.

Allow us here at Travelocity to pair you with up South Main hotels that suit your vacation preferences. Discover places with convenient on-site restaurants, around-the-clock service, and pools where your kids can make a splash. Some hotels may boast fitness rooms and spa services, while others feature game rooms and Wi-Fi access. To top it all off, you’ll score cheap hotels in South Main that let you spend more on your activities and less on your lodging. Book and bundle your flight and hotel deals together today and save up to $537. It’s time to explore a new city, and break out of your routine.


Recent South Main hotel reviews by fellow wanderers


*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.