Find a Hotel in Santa Ana

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top hotels in Santa Ana

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla Panama City Panama
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $114 total per night from May 8 to May 9
$114 total
May 8 - May 9
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Breakfast, clean, staff, location

Reviewed on Apr 26, 2026

Opens in a new windowPlaza Paitilla Inn Hotel
The Executive Hotel

The Executive Hotel

3.5 out of 5
Calle 52 Panama City Panama
Fully refundable
$81 nightly
The price is $89 total per night from May 5 to May 6
$89 total
May 5 - May 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Muy buen atención, desayuno rico, instalaciones limpias. Estuve cuatro dias hospedada y todo fue excelente.

Reviewed on Apr 26, 2026

Opens in a new windowThe Executive Hotel
Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste Panama City Provincia de Panamá
$111 nightly
The price is $122 total per night from Apr 29 to Apr 30
$122 total
Apr 29 - Apr 30
Total with taxes and fees
An outdoor pool is featured at this condo, along with a terrace and a garden. Staff at the 24-hour front desk can provide around-the-clock assistance.
Room was clean, AC was powerful, kitchen was well equipped, and the balcony had a little seating area where we dried swimwear. The pool was lovely and the common area is comfy. The only issue I had was the lack of communication with the staff, they read all of our messages but hardly responded. We ...

Reviewed on Apr 26, 2026

Opens in a new windowCasco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$138 nightly
The price is $151 total per night from May 5 to May 6
$151 total
May 5 - May 6
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Clean rooms, fresh breakfast, outdoor pool and bar great.

Reviewed on Apr 27, 2026

Opens in a new windowHotel Riu Plaza Panama
Principe Hotel and Suites

Principe Hotel and Suites

3 out of 5
Via Argentina Panama City Panama
Fully refundableReserve now, pay when you stay
$57 nightly
The price is $62 total per night from Apr 29 to Apr 30
$62 total
Apr 29 - Apr 30
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Unfortunately, this stay was a huge disappointment. We visit Panama frequently to see family and friends and usually choose El Cangrejo as our favorite neighborhood. Hotel El Principe used to be one of our top choices, but after this experience, that is no longer the case. The issues began at check-in, ...

Reviewed on Apr 25, 2026

Opens in a new windowPrincipe Hotel and Suites
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $100 total per night from Apr 28 to Apr 29
$100 total
Apr 28 - Apr 29
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
I had an exceptional stay at this hotel and would highly recommend it to anyone seeking a quality experience. The hotel has a cohesive aesthetic that is both elegant and welcoming. Cleanliness was maintained to an outstanding standard throughout. Staff were kind and the breakfast was delicious!

Reviewed on Apr 27, 2026

Opens in a new windowWaymore Hotel Spa & Casino
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$133 nightly
The price is $146 total per night from May 5 to May 6
$146 total
May 5 - May 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...
Thanks

Reviewed on Apr 27, 2026

Opens in a new windowCrowne Plaza Panama Airport by IHG
Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

4.5 out of 5
Amador Avenue & Van Hook Street Panama City Panama
Fully refundable
$74 nightly
The price is $81 total per night from May 10 to May 11
$81 total
May 10 - May 11
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 2 outdoor pools, and a gym. Families will appreciate the children's pool and onsite laundry facilities. Unwind ...
Excelente servicio, buena atención al cliente, el desayuno buffet estaba muy bueno. La habitación 10/10, tenía de todo. 100% recomendado. Volveríamos a ir.

Reviewed on Apr 26, 2026

Opens in a new windowRadisson Hotel Panama Canal
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
$293 nightly
The price is $293 total per night from Apr 28 to Apr 29
$293 total
Apr 28 - Apr 29
Total with taxes and fees
This all-inclusive property features a full-service spa, a nightclub, and 7 restaurants. Spend a day at the beach kayaking, or relax with free beach cabanas ...
We loved Dreams. The food and drinks were delicious. The property is beautiful and well maintained. Wish we could have stayed longer.

Reviewed on Apr 22, 2026

Opens in a new windowDreams Playa Bonita Panama - All Inclusive
Don't see what you're looking for?
See all available properties in Santa Ana
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santa Ana Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Santa Ana area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Santa Ana to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Santa Ana are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Santa Ana hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity