Book Hotels in Casco Bay Islands, ME

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Top Casco Bay Islands hotels

Portland Harbor Hotel

Portland Harbor Hotel

4 out of 5
468 Fore Street Portland ME
$308 nightly
The price is $340 total per night from Jul 5 to Jul 6
$340 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features 3 coffee shops/cafes and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, ...
"Great location"

Reviewed on Jun 17, 2026

Opens in a new windowPortland Harbor Hotel
Cambria Hotel Portland Downtown-Old Port

Cambria Hotel Portland Downtown-Old Port

3 out of 5
25 HANCOCK STREET Portland ME
Fully refundable
$269 nightly
The price is $297 total per night from Jun 21 to Jun 22
$297 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"Room was clean, staff was nice"

Reviewed on Jun 16, 2026

Opens in a new windowCambria Hotel Portland Downtown-Old Port
Portland Regency Hotel & Spa

Portland Regency Hotel & Spa

3.5 out of 5
20 Milk Street Portland ME
$314 nightly
The price is $347 total per night from Jun 21 to Jun 22
$347 total
Jun 21 - Jun 22
Total with taxes and fees
A full-service spa, a hot tub, and a restaurant are all featured at this smoke-free hotel. Unwind with a drink at one of the 2 bars/lounges and enjoy freebies ...
"Clean place, great location."

Reviewed on Jun 16, 2026

Opens in a new windowPortland Regency Hotel & Spa
La Quinta Inn & Suites by Wyndham Portland DT/Maine Med

La Quinta Inn & Suites by Wyndham Portland DT/Maine Med

3 out of 5
340 Park Ave Portland ME
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $154 total per night from Jun 22 to Jun 23
$154 total
Jun 22 - Jun 23
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport ...
"Fairly clean but pretty outdated. Very thin walls…can hear the neighbors like they are in your room. Free breakfast but mediocre at best. Fortunately there is a really good bakery nearby—tandem bakery was amazing."

Reviewed on Jun 16, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Portland DT/Maine Med
Comfort Inn South Portland Airport

Comfort Inn South Portland Airport

2.5 out of 5
90 Maine Mall Rd South Portland ME
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $123 total per night from Jun 28 to Jun 29
$123 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and a free airport shuttle. Traveling on business? Take advantage of ...
"Rooms could use a mirror in the common space and towel racks would be helpful."

Reviewed on Jun 17, 2026

Opens in a new windowComfort Inn South Portland Airport
Casco Bay Hotel Portland Airport - Maine Mall, an Ascend Collection Hotel

Casco Bay Hotel Portland Airport - Maine Mall, an Ascend Collection Hotel

3.5 out of 5
80 John Roberts Rd. South Portland ME
Fully refundable
$123 nightly
The price is $134 total per night from Jun 21 to Jun 22
$134 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free self parking, and a free airport shuttle. Business travelers can take ...
"Nice hotel with a good gym."

Reviewed on Jun 17, 2026

Opens in a new windowCasco Bay Hotel Portland Airport - Maine Mall, an Ascend Collection Hotel
Clarion Hotel Portland Airport ME

Clarion Hotel Portland Airport ME

2.5 out of 5
1230 Congress St Portland ME
$142 nightly
The price is $157 total per night from Jun 22 to Jun 23
$157 total
Jun 22 - Jun 23
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport shuttle. ...
"It felt like I went back in time to an old rundown hotel the Ramada inn used to to run that location and it was a good hotel for the price"

Reviewed on Jun 17, 2026

Opens in a new windowClarion Hotel Portland Airport ME
Clarion Pointe South Portland

Clarion Pointe South Portland

2 out of 5
675 Main Street I-95 South Portland ME
$95 nightly
The price is $104 total per night from Jun 21 to Jun 22
$104 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and WiFi in public areas. Enjoy ...
"My sons room needed to be changed. Toilet didn’t work and my friends room the toilet handle fell off . Lots of strange activity in this hotel . No hair dryers in rooms ."

Reviewed on Jun 17, 2026

Opens in a new windowClarion Pointe South Portland
Quality Inn & Suites South Portland

Quality Inn & Suites South Portland

2.5 out of 5
738 Main Street South Portland ME
Fully refundable
$89 nightly
The price is $97 total per night from Jun 18 to Jun 19
$97 total
Jun 18 - Jun 19
Total with taxes and fees
This hotel features free WiFi in public areas, free newspapers, and free self parking. Enjoy the free continental breakfast each morning. A garden and a picnic ...
"The bed was nice and comfortable and the room was clean. The toliet was so low. Very hard to get up from it. The breakfast was fair. No eggs and French toast was dry. We have had better breakfasts at other Quality Inns."

Reviewed on Jun 17, 2026

Opens in a new windowQuality Inn & Suites South Portland
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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