Book Hotels in Casco Bay Islands, ME
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Top Casco Bay Islands hotels

Portland Harbor Hotel
468 Fore Street Portland ME
Fully refundableReserve now, pay when you stay
$349 nightly
The price is $386 total per night from Jul 5 to Jul 6
$386 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features 3 coffee shops/cafes and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, ...
"We had a great stay! Everyone was so nice, helpful, and efficient! We loved the location. Portland is an amazing city! Wasn’t aware of the $35 a day charges but it worked out!"
Reviewed on Jun 12, 2026

Cambria Hotel Portland Downtown-Old Port
25 HANCOCK STREET Portland ME
Fully refundableReserve now, pay when you stay
$279 nightly
The price is $308 total per night from Jun 21 to Jun 22
$308 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"Very clean, beds very comfortable, hotel quiet"
Reviewed on Jun 14, 2026

Portland Regency Hotel & Spa
20 Milk Street Portland ME
Fully refundableReserve now, pay when you stay
$239 nightly
The price is $265 total per night from Jun 15 to Jun 16
$265 total
Jun 15 - Jun 16
Total with taxes and fees
A full-service spa, a hot tub, and a restaurant are all featured at this smoke-free hotel. Unwind with a drink at one of the 2 bars/lounges and enjoy freebies ...
"Hotel was spotless, highly recommended the spa treatment, the entire staff from check in, valet, and cleaning all extremely friendly. The drinks at the outside cafe great as well. Will definitely stay there for our next visit!"
Reviewed on Jun 14, 2026

La Quinta Inn & Suites by Wyndham Portland DT/Maine Med
340 Park Ave Portland ME
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $165 total per night from Jun 16 to Jun 17
$165 total
Jun 16 - Jun 17
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport ...
"Extremely clean property and great location!"
Reviewed on Jun 14, 2026

Comfort Inn South Portland Airport
90 Maine Mall Rd South Portland ME
Fully refundable
$115 nightly
The price is $126 total per night from Jun 28 to Jun 29
$126 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and a free airport shuttle. Traveling on business? Take advantage of ...
"Came in late for a one-night stay. You have to call the shuttle but it showed up promptly despite it being 1:30 AM. Clean and comfortable, lovely staff. Only thing was some grass trimming noise at 2:00 AM. Stuck in some earplugs and solved it. Good solid choice."
Reviewed on Jun 14, 2026

Casco Bay Hotel Portland Airport - Maine Mall, an Ascend Collection Hotel
80 John Roberts Rd. South Portland ME
Fully refundable
$113 nightly
The price is $123 total per night from Jun 15 to Jun 16
$123 total
Jun 15 - Jun 16
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free self parking, and a free airport shuttle. Business travelers can take ...
"Managers are putting a lot of effort in daily, seemed like they're slowly updating the rooms. Great place to stay for the price."
Reviewed on Jun 14, 2026

Clarion Hotel Portland Airport ME
1230 Congress St Portland ME
$127 nightly
The price is $140 total per night from Jun 22 to Jun 23
$140 total
Jun 22 - Jun 23
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport shuttle. ...
"This was fine for a 12 hour stay before a very early flight out of Portland. Drive to the airport from here is very easy and quick, and Ubers were easy to get. They have a shuttle to the airport, BUT it's earliest departure from the hotel is 4:30 a.m. We needed to leave closer to 4:00, so this did ..."
Reviewed on Jun 14, 2026

Clarion Pointe South Portland
675 Main Street I-95 South Portland ME
Fully refundable
$98 nightly
The price is $107 total per night from Jun 21 to Jun 22
$107 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and WiFi in public areas. Enjoy ...
"The only thing that I didn’t like was I had to ask for towels, there was no towels in our room other then that I have nothing bad to say, the staff was very nice"
Reviewed on Jun 14, 2026

Quality Inn & Suites South Portland
738 Main Street South Portland ME
Fully refundable
$85 nightly
The price is $92 total per night from Jun 16 to Jun 17
$92 total
Jun 16 - Jun 17
Total with taxes and fees
This hotel features free WiFi in public areas, free newspapers, and free self parking. Enjoy the free continental breakfast each morning. A garden and a picnic ...
"tv in the room didn’t work. carpet near the a/c was soaked. items from last person’s stay were left in the bathroom (NyQuil packets, hair clips, etc)."
Reviewed on Jun 13, 2026
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Casco Bay Islands with star-rating
Check Casco Bay Islands Hotels by Star Rating

4 Star Hotels
15 properties
Recent Casco Bay Islands hotel reviews by fellow wanderers

Comfort Inn South Portland Airport
5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Came in late for a one-night stay. You have to call the shuttle but it showed up promptly despite it being 1:30 AM. Clean and comfortable, lovely staff. Only thing was some grass trimming noise at 2:00 AM. Stuck in some earplugs and solved it. Good solid choice."
A verified traveler stayed at Comfort Inn South Portland Airport
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