Book Hotels in Casco Bay Islands, ME

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Top Casco Bay Islands hotels

Portland Harbor Hotel

Portland Harbor Hotel

4 out of 5
468 Fore Street Portland ME
Fully refundableReserve now, pay when you stay
$331 nightly
The price is $366 total per night from Jul 5 to Jul 6
$366 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features 3 coffee shops/cafes and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, ...
"Great room. Excellent location nice courtyard for food and drinks with firepit"

Reviewed on Jul 1, 2026

Opens in a new windowPortland Harbor Hotel
Cambria Hotel Portland Downtown-Old Port

Cambria Hotel Portland Downtown-Old Port

3 out of 5
25 HANCOCK STREET Portland ME
Fully refundableReserve now, pay when you stay
$256 nightly
The price is $283 total per night from Jul 5 to Jul 6
$283 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"We arrived to the hotel and were greeted by friendly staff. We opted out of the $40 valet parking and found free overnight parking on the street. The rooms were very clean, updated, and spacious. The bed was very comfortable. The location was perfect for getting around. I will definitely be ..."

Reviewed on Jul 2, 2026

Opens in a new windowCambria Hotel Portland Downtown-Old Port
Portland Regency Hotel & Spa

Portland Regency Hotel & Spa

3.5 out of 5
20 Milk Street Portland ME
Fully refundableReserve now, pay when you stay
$242 nightly
The price is $268 total per night from Jul 7 to Jul 8
$268 total
Jul 7 - Jul 8
Total with taxes and fees
A full-service spa, a hot tub, and a restaurant are all featured at this smoke-free hotel. Unwind with a drink at one of the 2 bars/lounges and enjoy freebies ...
"Two pillowcases head stains on them and there was also no hair dryer. Staff was not very friendly, especially some of the valet people. Pillows were also uncomfortable, and the Jacuzzi was broken. Also crazy that valet is $40 a night."

Reviewed on Jul 3, 2026

Opens in a new windowPortland Regency Hotel & Spa
Holiday Inn Portland-By the Bay by IHG

Holiday Inn Portland-By the Bay by IHG

4 out of 5
88 Spring St Portland ME
$199 nightly
The price is $220 total per night from Jul 5 to Jul 6
$220 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"Hotel staff is friendly and helpful. Rooms were clean and view of the bay was nice."

Reviewed on Jul 2, 2026

Opens in a new windowHoliday Inn Portland-By the Bay by IHG
La Quinta Inn & Suites by Wyndham Portland DT/Maine Med

La Quinta Inn & Suites by Wyndham Portland DT/Maine Med

3 out of 5
340 Park Ave Portland ME
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $165 total per night from Jul 5 to Jul 6
$165 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport ...
"Nothing special !"

Reviewed on Jul 2, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Portland DT/Maine Med
Comfort Inn South Portland Airport

Comfort Inn South Portland Airport

2.5 out of 5
90 Maine Mall Rd South Portland ME
Fully refundable
$120 nightly
The price is $131 total per night from Jul 5 to Jul 6
$131 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and a free airport shuttle. Traveling on business? Take advantage of ...
"Breakfast was pretty good"

Reviewed on Jul 3, 2026

Opens in a new windowComfort Inn South Portland Airport
Casco Bay Hotel Portland Airport - Maine Mall, an Ascend Collection Hotel

Casco Bay Hotel Portland Airport - Maine Mall, an Ascend Collection Hotel

3.5 out of 5
80 John Roberts Rd. South Portland ME
Fully refundable
$151 nightly
The price is $165 total per night from Jul 5 to Jul 6
$165 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free self parking, and a free airport shuttle. Business travelers can take ...
"The room smells like dog."

Reviewed on Jul 2, 2026

Opens in a new windowCasco Bay Hotel Portland Airport - Maine Mall, an Ascend Collection Hotel
Clarion Pointe South Portland

Clarion Pointe South Portland

2 out of 5
675 Main Street I-95 South Portland ME
Fully refundable
$99 nightly
The price is $108 total per night from Jul 20 to Jul 21
$108 total
Jul 20 - Jul 21
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and WiFi in public areas. Enjoy ...
"Right as you walked in the room it smelled of wet dog. The tub was durty we had no hand soap or wash cloths. The next day the had some kind of party right next to us load at 9 o'clock we ask for a new room . They had no problem giving us one and that was vary nice of them."

Reviewed on Jul 2, 2026

Opens in a new windowClarion Pointe South Portland
Quality Inn & Suites South Portland

Quality Inn & Suites South Portland

2.5 out of 5
738 Main Street South Portland ME
Fully refundable
$104 nightly
The price is $113 total per night from Jul 5 to Jul 6
$113 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features free WiFi in public areas, free newspapers, and free self parking. Enjoy the free continental breakfast each morning. A garden and a picnic ...
"Do not stay here!! We attempted to stay here ending out our 2 week vacation to all the states of New England. In all my years. Travels during military and civilian as a health care worker during Covid. I’ve never in my life received such bad treatment. The room was horribly disgusting as soon as ..."

Reviewed on Jul 2, 2026

Opens in a new windowQuality Inn & Suites South Portland
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Casco Bay Islands hotel reviews by fellow wanderers

Comfort Inn South Portland Airport

Comfort Inn South Portland Airport

5 out of 5
Posted 2 hours ago
Travelocity Verified Review
"Breakfast was pretty good"
A verified traveler stayed at Comfort Inn South Portland Airport
Comfort Inn South Portland Airport

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