Book Hotels in Casco Bay Islands, ME

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Top Casco Bay Islands hotels

Portland Harbor Hotel

Portland Harbor Hotel

4 out of 5
468 Fore Street Portland ME
The price is $396 total per night from Jul 7 to Jul 8
$396 total
per night
Jul 7 - Jul 8
This hotel features 3 coffee shops/cafes and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, ...
"Great stay in the middle of everything! Easy to walk to restaurants and shopping as well as the piers!"

Reviewed on Jul 4, 2026

Opens in a new windowPortland Harbor Hotel
Cambria Hotel Portland Downtown-Old Port

Cambria Hotel Portland Downtown-Old Port

3 out of 5
25 HANCOCK STREET Portland ME
Fully refundable
The price is $299 total per night from Jul 12 to Jul 13
$299 total
per night
Jul 12 - Jul 13
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"A decent place to stay in old port. Big room and nice staff. Room smelled like bleach and had a lightbulb burned out. Considering the price did not meet expectations."

Reviewed on Jul 5, 2026

Opens in a new windowCambria Hotel Portland Downtown-Old Port
Portland Regency Hotel & Spa

Portland Regency Hotel & Spa

3.5 out of 5
20 Milk Street Portland ME
The price is $278 total per night from Jul 7 to Jul 8
$278 total
per night
Jul 7 - Jul 8
A full-service spa, a hot tub, and a restaurant are all featured at this smoke-free hotel. Unwind with a drink at one of the 2 bars/lounges and enjoy freebies ...
"Excellent location! Staff we amazing. It has everything you need for a comfortable staff."

Reviewed on Jul 5, 2026

Opens in a new windowPortland Regency Hotel & Spa
Holiday Inn Portland-By the Bay by IHG

Holiday Inn Portland-By the Bay by IHG

4 out of 5
88 Spring St Portland ME
Fully refundable
The price is $271 total per night from Aug 2 to Aug 3
$271 total
per night
Aug 2 - Aug 3
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"Great staff."

Reviewed on Jul 5, 2026

Opens in a new windowHoliday Inn Portland-By the Bay by IHG
La Quinta Inn & Suites by Wyndham Portland DT/Maine Med

La Quinta Inn & Suites by Wyndham Portland DT/Maine Med

3 out of 5
340 Park Ave Portland ME
Fully refundableReserve now, pay when you stay
The price is $148 total per night from Jul 7 to Jul 8
$148 total
per night
Jul 7 - Jul 8
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport ...
"Bathroom was extremely small, shower floor was gross and water pressure in sink was basically just more than a trickle. Room was clean and comfortable otherwise. Parking was $10."

Reviewed on Jul 4, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Portland DT/Maine Med
Comfort Inn South Portland Airport

Comfort Inn South Portland Airport

2.5 out of 5
90 Maine Mall Rd South Portland ME
Fully refundable
The price is $151 total per night from Jul 8 to Jul 9
$151 total
per night
Jul 8 - Jul 9
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and a free airport shuttle. Traveling on business? Take advantage of ...
"Great location and comfort stay. However, some hotel guests play loud music and slash doors around 11 pm 1 am. Hotel management should have a rule to control such activities."

Reviewed on Jul 5, 2026

Opens in a new windowComfort Inn South Portland Airport
Casco Bay Hotel Portland Airport - Maine Mall, an Ascend Collection Hotel

Casco Bay Hotel Portland Airport - Maine Mall, an Ascend Collection Hotel

3.5 out of 5
80 John Roberts Rd. South Portland ME
Fully refundable
The price is $144 total per night from Jul 7 to Jul 8
$144 total
per night
Jul 7 - Jul 8
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free self parking, and a free airport shuttle. Business travelers can take ...
"Some of the reviews I read on the major search engine about the staff not being nice were not true. They were perfectly pleasant. The room was nice and clean. Zero complaints."

Reviewed on Jul 5, 2026

Opens in a new windowCasco Bay Hotel Portland Airport - Maine Mall, an Ascend Collection Hotel
Clarion Pointe South Portland

Clarion Pointe South Portland

2 out of 5
675 Main Street I-95 South Portland ME
Fully refundable
The price is $93 total per night from Jul 20 to Jul 21
$93 total
per night
Jul 20 - Jul 21
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and WiFi in public areas. Enjoy ...
"The bedroom floor was not clean"

Reviewed on Jul 5, 2026

Opens in a new windowClarion Pointe South Portland
Quality Inn & Suites South Portland

Quality Inn & Suites South Portland

2.5 out of 5
738 Main Street South Portland ME
Fully refundable
The price is $92 total per night from Jul 8 to Jul 9
$92 total
per night
Jul 8 - Jul 9
This hotel features free WiFi in public areas, free newspapers, and free self parking. Enjoy the free continental breakfast each morning. A garden and a picnic ...
"La Clim fonctionnait très bien, eau chaude à volonté, lit confo. Chambre viellot. Déjeuner ordinaire mais correct. Check in rapide."

Reviewed on Jul 5, 2026

Opens in a new windowQuality Inn & Suites South Portland
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Casco Bay Islands hotel reviews by fellow wanderers

Portland Regency Hotel & Spa

Portland Regency Hotel & Spa

5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Nice old hotel with a key location. My wife loved the spa and the garden restaurant was a nice feature."
A verified traveler stayed at Portland Regency Hotel & Spa
Portland Regency Hotel & Spa

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