Explore top 2026 4 Star Hotels in O'Fallon

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Top O'Fallon 4 Star hotels

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $179 total per night from Oct 1 to Oct 2
$179 total
Oct 1 - Oct 2
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
8.6/10 Excellent! (4,310 reviews)
"Location, staff, and room were all fantastic. We were surprised at the quiet of the hallways and room. We would totally stay again! Other travelers should know that you are required to use Valet parking on Friday and Saturday nights, something that isn't immediately clear until you get further information ..."

Reviewed on Sep 21, 2026

Opens in a new windowHyatt Regency St. Louis at The Arch
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $173 total per night from Oct 18 to Oct 19
$173 total
Oct 18 - Oct 19
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Opens in a new window21C Museum Hotel St Louis
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave St. Louis MO
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $189 total per night from Sep 27 to Sep 28
$189 total
Sep 27 - Sep 28
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
Opens in a new windowLive by Loews - St.Louis
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
3550 Samuel Sheppard Drive St. Louis MO
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $139 total per night from Oct 5 to Oct 6
$139 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...
8.8/10 Excellent! (1,167 reviews)
"Nice place. Very clean. Good water pressure. Lol. I enjoyed the art throughout the hotel. The rooftop bar area is really cool. I didn’t try breakfast at the restaurant. Only coffee to go as I was otw out."

Reviewed on Sep 21, 2026

Opens in a new windowAngad Arts Hotel St. Louis, Tapestry Collection by Hilton
The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
212 N Kingshighway St. Louis MO
Fully refundableReserve now, pay when you stay
$174 nightly
The price is $205 total per night from Oct 4 to Oct 5
$205 total
Oct 4 - Oct 5
Total with taxes and fees
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
9.2/10 Wonderful! (1,005 reviews)
"I have stayed at The Chase multiple times and each time is wonderful. This time as well was top-notch. It is one of my favorite places to have a staycation!"

Reviewed on Sep 20, 2026

Opens in a new window The Royal Sonesta Chase Park Plaza St. Louis
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $129 total per night from Oct 5 to Oct 6
$129 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...
9/10 Wonderful! (1,798 reviews)
"Traveling through, the hotel is a bit off the freeway but worth it. We were there early weekday, so the 2 best restaurants were closed, the Asian noodle food was pretty bad, tasteless, disappointing for a casino. Consequently we didn’t try the other restaurants for breakfast, just headed out next ..."

Reviewed on Sep 21, 2026

Opens in a new windowRiver City Casino & Hotel
The Westin St. Louis

The Westin St. Louis

4.5 out of 5
811 Spruce St St. Louis MO
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $153 total per night from Oct 18 to Oct 19
$153 total
Oct 18 - Oct 19
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...
8.6/10 Excellent! (1,008 reviews)
"We were in town for the games. PERFECT location close to the stadium. Especially if you have seats on the 3rd baseline. Comfortable beds and pillows very clean and spacious room. Excellent food and drinks in the restaurant."

Reviewed on Sep 21, 2026

Opens in a new windowThe Westin St. Louis
Marriott St. Louis Grand

Marriott St. Louis Grand

4 out of 5
800 Washington Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $181 total per night from Oct 2 to Oct 3
$181 total
Oct 2 - Oct 3
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.2/10 Very Good! (1,004 reviews)
"Staff was great! A small repair in bathroom work but lacked class."

Reviewed on Sep 21, 2026

Opens in a new windowMarriott St. Louis Grand
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $132 total per night from Sep 27 to Sep 28
$132 total
Sep 27 - Sep 28
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
8.6/10 Excellent! (1,366 reviews)
"The staff were excellent; the air conditioning in the hotel wasn't working; it was extremely hot in St Louis and the room temp was 74 and 76 the nights we were there. The staff were very apologetic but the fact that the hotel wasn't able to resolve this sooner was not great. It was very difficult ..."

Reviewed on Sep 21, 2026

Opens in a new windowMagnolia Hotel St. Louis, a Tribute Portfolio Hotel
Moonrise Hotel

Moonrise Hotel

4 out of 5
6177 Delmar Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$169 nightly
The price is $201 total per night from Sep 28 to Sep 29
$201 total
Sep 28 - Sep 29
Total with taxes and fees
The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (2,024 reviews)
"The hotel and room were great, as we're the staff but the television quit working and they couldn't fix it and did not offer any sort of restitution so to speak."

Reviewed on Sep 20, 2026

Opens in a new windowMoonrise Hotel
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4 Star Hotels O'Fallon

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in O'Fallon 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in O'Fallon will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in O'Fallon, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent O'Fallon hotel reviews by fellow wanderers

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

5 out of 5
Posted 3 hours ago
Travelocity Verified Review
"Location, staff, and room were all fantastic. We were surprised at the quiet of the hallways and room. We would totally stay again! Other travelers should know that you are required to use Valet parking on Friday and Saturday nights, something that isn't immediately clear until you get further information from the hotel. Valet staff were great! Bathroom had a few signs of aging - peeling wall paper in a corner and the shower door leaked a lot. Additionally, the shower had no handle or grab bar, which is particularly tricky as there was a step in/out and the shower floor was slippery."
A verified traveler stayed at Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch

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