Explore top 2026 4 Star Hotels in O'Fallon

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Top O'Fallon 4 Star hotels

The Westin St. Louis

The Westin St. Louis

4.5 out of 5
811 Spruce St St. Louis MO
$135 nightly
The price is $158 total per night from Apr 5 to Apr 6
$158 total
Apr 5 - Apr 6
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...
8.6/10 Excellent! (1,006 reviews)
I liked everything the breakfast price was a bit high

Reviewed on Mar 9, 2026

Opens in a new windowThe Westin St. Louis
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
$131 nightly
The price is $153 total per night from Apr 5 to Apr 6
$153 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,646 reviews)
Stay was great and the hotel was a close walk to Enterprise Center.

Reviewed on Mar 9, 2026

Opens in a new window21C Museum Hotel St Louis
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
$169 nightly
The price is $199 total per night from Mar 23 to Mar 24
$199 total
Mar 23 - Mar 24
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
8.6/10 Excellent! (4,009 reviews)
The hotel was great. I love the options to dine at the hotel. The brewery had amazing food with great staff and the breakfast buffet was wonderful. The front staff were all polite and friendly. The hotel store was open early and late which was very convenient. The area was also pleasant and had a ...

Reviewed on Mar 9, 2026

Opens in a new windowHyatt Regency St. Louis at The Arch
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave St. Louis MO
$149 nightly
The price is $177 total per night from Apr 3 to Apr 4
$177 total
Apr 3 - Apr 4
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (1,130 reviews)
Room was excellent clean no issues

Reviewed on Mar 7, 2026

Opens in a new windowLive by Loews - St.Louis
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $115 total per night from Mar 16 to Mar 17
$115 total
Mar 16 - Mar 17
Total with taxes and fees
This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...
9/10 Wonderful! (1,498 reviews)
The staff were very friendly and efficient. Check in was a breeze.

Reviewed on Mar 8, 2026

Opens in a new windowRiver City Casino & Hotel
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
$125 nightly
The price is $149 total per night from Mar 22 to Mar 23
$149 total
Mar 22 - Mar 23
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
8.8/10 Excellent! (1,258 reviews)
Had a great time, clean room, great food at the bar wonderful historic hotel, lots of nostalgia

Reviewed on Mar 8, 2026

Opens in a new windowMagnolia Hotel St. Louis, a Tribute Portfolio Hotel
Moonrise Hotel

Moonrise Hotel

4 out of 5
6177 Delmar Blvd St. Louis MO
$132 nightly
The price is $157 total per night from Mar 11 to Mar 12
$157 total
Mar 11 - Mar 12
Total with taxes and fees
The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (1,927 reviews)
The staff was fantastic!!

Reviewed on Mar 9, 2026

Opens in a new windowMoonrise Hotel
 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
212 N Kingshighway St. Louis MO
$174 nightly
The price is $205 total per night from Mar 15 to Mar 16
$205 total
Mar 15 - Mar 16
Total with taxes and fees
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
9/10 Wonderful! (1,006 reviews)
This place is awesome. Great location great property. Right across the street from the park so if you’re someone who likes to take walk or go for a run, it’s great place. It also has to have the absolute best gym I’ve ever seen at a hotel.

Reviewed on Mar 9, 2026

Opens in a new window The Royal Sonesta Chase Park Plaza St. Louis
St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton

4 out of 5
1820 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$193 nightly
The price is $229 total per night from Mar 22 to Mar 23
$229 total
Mar 22 - Mar 23
Total with taxes and fees
This luxury hotel's 7 restaurants, 3 bars/lounges, and 24-hour gym are some of the featured amenities. Enjoy the seasonal outdoor pool and perks like free WiFi. ...
8.6/10 Excellent! (1,006 reviews)
This place is from the Gilded Age and beautiful. The flooring, tiling, the atmosphere was cool. The one thing, though, was that the valet was extremely difficult to work with and not labeled to where to go, there was no signage anywhere. We had to drive around the city and find a place to park to ...

Reviewed on Mar 9, 2026

Opens in a new windowSt. Louis Union Station Hotel, Curio Collection by Hilton
Hilton Pennywell St. Louis at the Arch

Hilton Pennywell St. Louis at the Arch

4 out of 5
400 Olive St St. Louis MO
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $140 total per night from Mar 16 to Mar 17
$140 total
Mar 16 - Mar 17
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the express check-in, express check-out, and valet parking. ...
8.8/10 Excellent! (1,031 reviews)
The room was dirty, sheets weren’t clean, bathroom was filthy, each light was different and flickering, HVAC was SOOO loud we were up all night, hall HVAC was like a train going through the hall. Avoid like the plague!!!

Reviewed on Mar 9, 2026

Opens in a new windowHilton Pennywell St. Louis at the Arch
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4 Star Hotels O'Fallon

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in O'Fallon 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in O'Fallon will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in O'Fallon, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

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