Find a Hotel in South Central Houston

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Top hotels in South Central Houston

Wanderstay Boutique Hotel

Wanderstay Boutique Hotel

2 out of 5
520 Sampson St Houston TX
$117 nightly
The price is $137 total per night from Jan 12 to Jan 13
$137 total
Jan 12 - Jan 13, 2026
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A communal living room, express check-in, and express check-out are also ...
The room was adorable and the staff were very friendly and informative.

Reviewed on Dec 20, 2025

Opens in a new windowWanderstay Boutique Hotel
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St Houston TX
Fully refundable
$169 nightly
The price is $198 total per night from Jan 1 to Jan 2
$198 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Clean quick check in

Reviewed on Dec 19, 2025

Opens in a new windowInterContinental Houston by IHG
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
Fully refundableReserve now, pay when you stay
$173 nightly
The price is $201 total per night from Jan 1 to Jan 2
$201 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Everything was great. No complaints here. Very convenient location and can access from the Hospital Bridges.

Reviewed on Dec 26, 2025

Opens in a new windowThe Westin Houston Medical Center/Museum District
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street Houston TX
Fully refundableReserve now, pay when you stay
$170 nightly
The price is $199 total per night from Jan 9 to Jan 10
$199 total
Jan 9 - Jan 10, 2026
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
Very nice, clean room. No8thing fancy, but not bad at all.

Reviewed on Dec 25, 2025

Opens in a new windowHouston Marriott Medical Center/Museum District
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$277 nightly
The price is $324 total per night from Jan 1 to Jan 2
$324 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury aparthotel. Traveling on business? Take advantage of the 24-hour business ...
The room was lovely. Outstanding service.

Reviewed on Dec 27, 2025

Opens in a new windowHotel Zaza Houston Museum District
Hilton University of Houston

Hilton University of Houston

3.5 out of 5
4450 University Drive Houston TX
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $172 total per night from Jan 6 to Jan 7
$172 total
Jan 6 - Jan 7, 2026
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...
Free breakfast made this great. Wouldn’t have been happy without it. But people are nice. No food around unless school is actively in session

Reviewed on Dec 22, 2025

Opens in a new windowHilton University of Houston
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $108 total per night from Jan 4 to Jan 5
$108 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
Satisfactory

Reviewed on Dec 28, 2025

Opens in a new windowHilton Houston Plaza/Medical Center
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $130 total per night from Jan 23 to Jan 24
$130 total
Jan 23 - Jan 24, 2026
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Room is very clean and nice. Lovely staff!

Reviewed on Dec 22, 2025

Opens in a new windowDoubleTree by Hilton Houston Medical Center Hotel & Suites
Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown

2 out of 5
2510 Hamilton St Houston TX
$77 nightly
The price is $91 total per night from Jan 1 to Jan 2
$91 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like self-serve breakfast and WiFi in ...
Room was nice, clean and close to midtown

Reviewed on Dec 26, 2025

Opens in a new windowDowntowner Inns - Houston Downtown
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Central Houston Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on South Central Houston area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near South Central Houston to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near South Central Houston are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent South Central Houston hotel reviews by fellow wanderers

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