Find a Hotel in South Central Houston

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top hotels in South Central Houston

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
Fully refundableReserve now, pay when you stay
$172 nightly
The price is $199 total per night from Apr 18 to Apr 19
$199 total
Apr 18 - Apr 19
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Clean Room,Very friendly staff, and close proximity to site of meeting in Texas Medical Center

Reviewed on Apr 10, 2026

Opens in a new windowThe Westin Houston Medical Center/Museum District
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St Houston TX
Fully refundable
$188 nightly
The price is $221 total per night from Apr 18 to Apr 19
$221 total
Apr 18 - Apr 19
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
I've stayed at Intercontinental several times in the past including my honeymoon and have had a great experience. However, my experience at the Houston location wasn't as smooth. To start, the bell man was great, he was personable and was ready to help us. We had 4 big luggages and he was ready and ...

Reviewed on Apr 13, 2026

Opens in a new windowInterContinental Houston by IHG
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$235 nightly
The price is $274 total per night from Apr 26 to Apr 27
$274 total
Apr 26 - Apr 27
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
Hallways a little noisy night. Meeting had hotel meal, which was delish, and served very well by the staff.

Reviewed on Apr 11, 2026

Opens in a new windowHotel Zaza Houston Museum District
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street Houston TX
Fully refundableReserve now, pay when you stay
$207 nightly
The price is $242 total per night from Apr 25 to Apr 26
$242 total
Apr 25 - Apr 26
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
Right in the center of the Medical District. Didn’t even have to go outside to get to my wife’s appointment.

Reviewed on Apr 7, 2026

Opens in a new windowHouston Marriott Medical Center/Museum District
Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown

2 out of 5
2510 Hamilton St Houston TX
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $101 total per night from Apr 20 to Apr 21
$101 total
Apr 20 - Apr 21
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like self-serve breakfast and WiFi in ...
Okay for a short stay. For a motel it is in a fairly decent condition.

Reviewed on Apr 11, 2026

Opens in a new windowDowntowner Inns - Houston Downtown
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $117 total per night from Apr 19 to Apr 20
$117 total
Apr 19 - Apr 20
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
Was called handicap room, however my husband who is in a wheelchair, couldn’t get in shower and barely to toilet. No microwave in room, but they did bring one.

Reviewed on Apr 14, 2026

Opens in a new windowHilton Houston Plaza/Medical Center
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $123 total per night from Apr 25 to Apr 26
$123 total
Apr 25 - Apr 26
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
The staff was super friendly. My only complaint was that my room was really nasty. Found hair everywhere and stains on the bed and towels

Reviewed on Apr 13, 2026

Opens in a new windowDoubleTree by Hilton Houston Medical Center Hotel & Suites
Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown

2 out of 5
2419 Riverside Dr Houston TX
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $116 total per night from Apr 15 to Apr 16
$116 total
Apr 15 - Apr 16
Total with taxes and fees
Free self parking is available and the motel's front desk is staffed around-the-clock. WiFi in public areas is free. Express check-out is also provided.
Shower water pressure was not always present

Reviewed on Apr 12, 2026

Opens in a new windowAmericas Best Value Inn Medical Center Downtown
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

2.5 out of 5
1301 Braeswood Blvd Houston TX
Fully refundableReserve now, pay when you stay
$74 nightly
The price is $87 total per night from Apr 23 to Apr 24
$87 total
Apr 23 - Apr 24
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference space. Guests will ...
Staff was friendly!

Reviewed on Apr 11, 2026

Opens in a new windowExtended Stay America Suites Houston Med Ctr Braeswood Bl
Don't see what you're looking for?
See all available properties in South Central Houston
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Central Houston Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on South Central Houston area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near South Central Houston to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near South Central Houston are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent South Central Houston hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity