Book Hotels in Casco Bay Islands, ME

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight
May 6 - May 7
Tomorrow
May 7 - May 8
This weekend
May 8 - May 10
Next weekend
May 15 - May 17

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Casco Bay Islands hotels

Portland Harbor Hotel

Portland Harbor Hotel

4 out of 5
468 Fore Street Portland ME
Fully refundableReserve now, pay when you stay
$221 nightly
The price is $244 total per night from May 10 to May 11
$244 total
May 10 - May 11
Total with taxes and fees
This hotel features 3 coffee shops/cafes and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, ...
Hotel was within walking distance to everything we wanted! Friendly, helpful staff, bartender was great! Extremely clean hotel, would absoulty stay again!

Reviewed on May 4, 2026

Opens in a new windowPortland Harbor Hotel
Cambria Hotel Portland Downtown-Old Port

Cambria Hotel Portland Downtown-Old Port

3 out of 5
25 HANCOCK STREET Portland ME
Fully refundable
$169 nightly
The price is $187 total per night from May 27 to May 28
$187 total
May 27 - May 28
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Beautiful hotel, staff was wonderful and we would stay here again.

Reviewed on May 6, 2026

Opens in a new windowCambria Hotel Portland Downtown-Old Port
Portland Regency Hotel & Spa

Portland Regency Hotel & Spa

3.5 out of 5
20 Milk Street Portland ME
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $178 total per night from May 26 to May 27
$178 total
May 26 - May 27
Total with taxes and fees
A full-service spa, a hot tub, and a restaurant are all featured at this smoke-free hotel. Unwind with a drink at one of the 2 bars/lounges and enjoy freebies ...
Excellent location & great service throughout.

Reviewed on May 6, 2026

Opens in a new windowPortland Regency Hotel & Spa
HomeAwhile

HomeAwhile

4 out of 5
205 Southborough Drive Scarborough ME
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $136 total per night from May 31 to Jun 1
$136 total
May 31 - Jun 1
Total with taxes and fees
This aparthotel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities ...
great location and clean! Very new!

Reviewed on May 5, 2026

Opens in a new windowHomeAwhile
Holiday Inn Portland-By the Bay by IHG

Holiday Inn Portland-By the Bay by IHG

4 out of 5
88 Spring St Portland ME
Fully refundable
$118 nightly
The price is $131 total per night from May 10 to May 11
$131 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Well, it was definitely an over priced hotel stay. The bathrooms in the rooms could definitely use some updates. The ceiling is very low in the bathrooms and had many peoples hairs stuck to the ceiling which was nasty. How the cleaners do not notice is disgraceful. The ceiling could be easily reached ...

Reviewed on May 3, 2026

Opens in a new windowHoliday Inn Portland-By the Bay by IHG
Hyatt Place Portland Downtown - Old Port Square

Hyatt Place Portland Downtown - Old Port Square

3 out of 5
433 Fore St Portland ME
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $148 total per night from May 10 to May 11
$148 total
May 10 - May 11
Total with taxes and fees
This hotel features a 24-hour gym and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free ...
I enjoyed my stay at the Hyatt place last week. Unfortunately my travel companion left a sweatshirt behind. Less than a week later I came in asking if it was in the lost and found and I was told to come back the following day. When I returned they said they needed another 10 minutes to check. I went ...

Reviewed on May 5, 2026

Opens in a new windowHyatt Place Portland Downtown - Old Port Square
Inn at St John Portland In-Town

Inn at St John Portland In-Town

2.5 out of 5
939 Congress St Portland ME
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $130 total per night from May 10 to May 11
$130 total
May 10 - May 11
Total with taxes and fees
This bed & breakfast features free WiFi in public areas, concierge services, and free self parking. Enjoy the free continental breakfast each morning. A lobby ...
Very charming building with very helpful and attentive staff. Would return! Great deal as well.

Reviewed on May 6, 2026

Opens in a new windowInn at St John Portland In-Town
The Westin Portland Harborview

The Westin Portland Harborview

4 out of 5
157 High St Portland ME
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $163 total per night from May 10 to May 11
$163 total
May 10 - May 11
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
Parking garage right next to hotel, close to restaurants, old port and music venues.

Reviewed on Apr 29, 2026

Opens in a new windowThe Westin Portland Harborview
Clarion Hotel Portland Airport ME

Clarion Hotel Portland Airport ME

2.5 out of 5
1230 Congress St Portland ME
Fully refundable
$88 nightly
The price is $98 total per night from May 13 to May 14
$98 total
May 13 - May 14
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport shuttle. ...
Room was clean. Breakfast is pay as you go. Key system worked most of the time.

Reviewed on May 6, 2026

Opens in a new windowClarion Hotel Portland Airport ME
Don't see what you're looking for?
See all available properties in Casco Bay Islands
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Casco Bay Islands hotel reviews by fellow wanderers

Inn at St John Portland In-Town

Inn at St John Portland In-Town

4 out of 5
Posted 5 hours ago
Travelocity Verified Review
"Very charming building with very helpful and attentive staff. Would return! Great deal as well."
A verified traveler stayed at Inn at St John Portland In-Town
Inn at St John Portland In-Town

Explore More Ways to Travel with Travelocity