Book Hotels in Hillsboro, MO
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Top Hillsboro hotels

Drury Inn & Suites Southwest St. Louis
Comfortable and great food
Reviewed on Apr 24, 2026

Pear Tree Inn St. Louis Arnold
The hotel was great. Friendly staff, clean, easy access to the building, plenty of parking. This was our first time staying with Drury and we will definitely be staying again.
Reviewed on Apr 23, 2026

The Wildwood Hotel
The hotel is really nice and close to good restaurants.
Reviewed on Apr 22, 2026

River City Casino & Hotel
The room was clean and well appointed with a large bathroom and great shower. Comfortable beds. Staff friendly and helpful, especially Emani at the front desk. Highly recommended.
Reviewed on Apr 24, 2026

Holiday Inn Express & Suites St. Louis West - Fenton by IHG
Third floor room that I was I was very noisy at night. From around 9:00pm on sounded like a helicopter was hovering outside my window. The bed was worn completely out and was very noisy. Needless to say there wasn’t much sleep. Probably will find a different hotel our next trip to Fenton.
Reviewed on Apr 19, 2026

Best Western St. Louis-Kirkwood Route 66
Pet friendly. The staff was helpful and the property was clean.
Reviewed on Apr 22, 2026

Best Western St. Louis Inn
My stay overnight stay was pleasant.
Reviewed on Apr 24, 2026

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Great hotel for the price.
Reviewed on Apr 24, 2026

Wingate by Wyndham St. Louis/Fenton Route 66
Multiple lights did not work and the halls were dirty.
Reviewed on Apr 23, 2026
Hillsboro Hotel & Travel Guide\n
There are no Travelocity-accredited hotels in Hillsboro. Savvy travelers hoping to explore Hillsboro are best off booking one of the 18 rooms less than 19 miles (30 kilometers) away.
The Holiday Inn St. Louis West Six Flags, Missouri, which is the nearest accommodation, is situated 18 miles (29 kilometers) from the city center of Hillsboro. A secondary handy choice is the Hampton Inn & Suites St.Louis South at I-55, in Missouri, about 20 miles (32 kilometers) from the central area of Hillsboro.
The Comfort Inn Near Six Flags St. Louis is approximately 18 miles (30 kilometers) from the main part of Hillsboro. Another hotel is the Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, which is approximately 10 miles (16 kilometers) away. Some other alternatives around Hillsboro are the Holiday Inn St. Louis-South County Center and the Quality Inn Near Six Flags St. Louis.
The closest accommodation options in Farmington include Festus and Ironton. Festus is 10 miles (17 kilometers) to the east of Hillsboro, while Ironton is 45 miles (73 kilometers) to the east. Lodgings in Festus include the Lexington Inn - Shalimar Plaza & Conference Center and Comfort Inn. The Fort Davidson Hotel and Shepherd Mountain Inn are a selection of the Travelocity-registered hotels in Ironton.
If you are into sports and enjoy attending thrilling games make sure you spend a day at Busch Stadium, situated 35 miles (53 kilometers) to the northeast of Hillsboro. Wise travelers that like the convenience of booking accommodation in the neighborhood, reserve a room in the Four Seasons Hotel St Louis or Grand Center Inn.
Located 35 miles (57 kilometers) from central Hillsboro is Lambert-St. Louis International Airport. Stay nearby in Travelocity-listed accommodation at Marriott St. Louis Airport or Holiday Inn St. Louis-Airport.
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Drury Inn & Suites Southwest St. Louis
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