Book Hotels in De Soto, MO
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Top De Soto hotels

82 Acre Hobby Farm with Lincoln Log Cabin
The cabin was wonderful with many extras like snacks and coffee.
Reviewed on Oct 18, 2025

Secluded cabin on private property
Would definitely recommend this cabin! Very comfortable beds, well stocked kitchen, and beautiful surroundings. The host was very helpful and easy to get in touch with. Great place to stay in the area, and wonderful front and back porch to enjoy a cup of coffee in the morning.
Reviewed on Nov 12, 2025

Drury Inn & Suites St. Louis Arnold
The check in process was extremely smooth and the agent was very friendly! During our stay, we regularly saw staff doing minor cleanup (mud tracked in, etc), staffing the evening kick-back and breakfast, including keeping the food refreshed and full. The room was clean and comfortable. It was a wonderful, ...
Reviewed on Nov 23, 2025

Pear Tree Inn St. Louis Arnold
The staff they were friendly and help me out after a difficult day. I would highly recommend staying here.
Reviewed on Nov 26, 2025

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Very clean and comfortable room, nice front desk staff. Great breakfast
Reviewed on Nov 24, 2025

Super 8 by Wyndham Farmington
The room was excellent and the staff was extremely nice
Reviewed on Nov 25, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
Was very good stay
Reviewed on Dec 3, 2025

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
The staff was amazing!!
Reviewed on Nov 22, 2025

Baymont by Wyndham Festus
The hotel was very clean and had a nice variety for breakfast. Breakfast area was kept clean and well stocked.
Reviewed on Nov 20, 2025
De Soto Hotel & Travel Guide\n
Dreaming about exploring De Soto? Travelocity has no hotels and apartments, however, there are 4 places to rest and relax within an easy drive of De Soto.
The nearest Travelocity-listed accommodation is the Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, Missouri, 9 miles (15 kilometers) from the middle of De Soto. Another Travelocity accommodation option is the Lexington Inn - Shalimar Plaza & Conference Center, situated in Missouri, 10 miles (15 kilometers) from the middle of De Soto.
The Comfort Inn is 10 miles (15 kilometers) outside the city center of De Soto. An alternative accommodation option is the Super 8 Pevely, which can be found approximately 14 miles (22 kilometers) away. The Super 8 Potosi Mo as well as the Super 8 Bonne Terre are two other Travelocity-listed accommodation options worth checking out around De Soto.
There are various Travelocity-registered hotels in Pilot Knob, which is situated 35 miles (55 kilometers) south of De Soto. The Fort Davidson Hotel and Shepherd Mountain Inn are a few of the establishments here.
Make sure you get your fix of local sport by making the journey to Busch Stadium, which is 40 miles (64 kilometers) to the northeast of De Soto. Enlightened travelers wanting to find a Travelocity-listed room near to the action can choose from the Four Seasons Hotel St Louis or the Grand Center Inn.
Lambert-St. Louis International Airport is a practical arrival point for flights, and is situated 45 miles (72 kilometers) away from De Soto. Travelocity-listed hotels close to Lambert-St. Louis International Airport include Marriott St. Louis Airport and Holiday Inn St. Louis-Airport.
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Baymont Inn and Suites by Wyndham Farmington, MO
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