Book Hotels in De Soto, MO

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top De Soto hotels

Gated 35-Acre De Soto Estate: Pool, Lake & Patio!

Gated 35-Acre De Soto Estate: Pool, Lake & Patio!

De Soto MO
This vacation home features a garden, laundry facilities, and barbecue grills.
"Great place for a family to spend time together. Lots of things to do! Beautiful land with pond and flowers. Turtles at the pond. Pool with bathhouse. Fun games in the garage, upstairs is a great set-up with darts, billiards, smart tv, shuffle board, mini kitchen. The place was immaculately clean! ..."

Reviewed on Jul 28, 2026

Get rates
Opens in a new windowGated 35-Acre De Soto Estate: Pool, Lake & Patio!
Secluded cabin on private property

Secluded cabin on private property

De Soto MO
This cabin features a garden, laundry facilities, and barbecue grills.
"Such a beautiful cabin in a secluded and peaceful area. I’m sure it’s gorgeous in the fall. Definitely would recommend!"

Reviewed on Aug 30, 2026

Get rates
Opens in a new windowSecluded cabin on private property
82 Acre Hobby Farm with Lincoln Log Cabin

82 Acre Hobby Farm with Lincoln Log Cabin

De Soto MO
$268 nightly
The price is $284 total per night from Sep 30 to Oct 1
$284 total
Sep 30 - Oct 1
Total with taxes and fees
This cabin features a garden, laundry facilities, and barbecue grills.
"Loved the view from the back deck! Saw lots of wildlife. Very peaceful location. The house was clean and nicely decorated. We enjoyed our stay!"

Reviewed on Aug 13, 2026

Opens in a new window82 Acre Hobby Farm with Lincoln Log Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
$133 nightly
The price is $151 total per night from Sep 17 to Sep 18
$151 total
Sep 17 - Sep 18
Total with taxes and fees
This cabin includes express check-out and a virtual front desk. Take advantage of the free self parking.
"Perfect trip!!! I can’t wait to go back when it gets colder outside :)"

Reviewed on Sep 10, 2026

Opens in a new windowPostcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Drury Inn & Suites St. Louis Arnold

Drury Inn & Suites St. Louis Arnold

3 out of 5
3800 State Rt 141 Arnold MO
Fully refundableReserve now, pay when you stay
$126 nightly
The price is $146 total per night from Sep 20 to Sep 21
$146 total
Sep 20 - Sep 21
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"Parking can be challenging, but the hotel was excellent"

Reviewed on Sep 8, 2026

Opens in a new windowDrury Inn & Suites St. Louis Arnold
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

2.5 out of 5
1303 Veterans Blvd Festus MO
Fully refundable
$73 nightly
The price is $83 total per night from Oct 11 to Oct 12
$83 total
Oct 11 - Oct 12
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business ...
"I loved the breakfasts, the reception was nice but when I got there the blanket appeared to have a very questionable stain. I was stressed and just wanted to be in my room so I changed the sheets and everything my self. Also of the week I was there the coffee wasnt available for 3 of the days. I ..."

Reviewed on Sep 10, 2026

Opens in a new windowComfort Inn Festus - St Louis South
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

2.5 out of 5
1201 Drury Ln Arnold MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $104 total per night from Sep 15 to Sep 16
$104 total
Sep 15 - Sep 16
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Opens in a new windowPear Tree Inn St. Louis Arnold
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
$55 nightly
The price is $60 total per night from Oct 4 to Oct 5
$60 total
Oct 4 - Oct 5
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Opens in a new windowBaymont Inn and Suites by Wyndham Farmington, MO
Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection

2.5 out of 5
4245 Hunt Rd Farmington MO
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $119 total per night from Sep 17 to Sep 18
$119 total
Sep 17 - Sep 18
Total with taxes and fees
A golf course and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
Opens in a new windowCrown Pointe Lodge, BW Signature Collection
Don't see what you're looking for?
See all available properties in De Soto
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

De Soto Hotel & Travel Guide\n

Dreaming about exploring De Soto? Travelocity has no hotels and apartments, however, there are 4 places to rest and relax within an easy drive of De Soto.

The nearest Travelocity-listed accommodation is the Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, Missouri, 9 miles (15 kilometers) from the middle of De Soto. Another Travelocity accommodation option is the Lexington Inn - Shalimar Plaza & Conference Center, situated in Missouri, 10 miles (15 kilometers) from the middle of De Soto.

The Comfort Inn is 10 miles (15 kilometers) outside the city center of De Soto. An alternative accommodation option is the Super 8 Pevely, which can be found approximately 14 miles (22 kilometers) away. The Super 8 Potosi Mo as well as the Super 8 Bonne Terre are two other Travelocity-listed accommodation options worth checking out around De Soto.

There are various Travelocity-registered hotels in Pilot Knob, which is situated 35 miles (55 kilometers) south of De Soto. The Fort Davidson Hotel and Shepherd Mountain Inn are a few of the establishments here.

Make sure you get your fix of local sport by making the journey to Busch Stadium, which is 40 miles (64 kilometers) to the northeast of De Soto. Enlightened travelers wanting to find a Travelocity-listed room near to the action can choose from the Four Seasons Hotel St Louis or the Grand Center Inn.

Lambert-St. Louis International Airport is a practical arrival point for flights, and is situated 45 miles (72 kilometers) away from De Soto. Travelocity-listed hotels close to Lambert-St. Louis International Airport include Marriott St. Louis Airport and Holiday Inn St. Louis-Airport.

Frequently asked questions

What are the top kid-friendly hotels in De Soto?
From carefully considered amenities to rooms with bunk beds, kid-friendly hotels are equipped with features that can help transform a nice family vacation into a fantastic one. These De Soto properties make vacationing with your youngsters a snap: Put your bags down at NEW! Traditional Country Home in De Soto w/ Yard!. It comes with a firepit, a fireplace and a flair for making families feel at home. Beautiful 2 bedroom unit at resort, sleeps 6 is also a great choice. After a fun day of exploring, return to your comfy room and perks like a sauna and a king bed.
Where can I find cheap hotels in De Soto?
At Travelocity you'll find really nice hotels in De Soto at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near De Soto rather than in De Soto. We may find you even better rates, too.
How do I find the best De Soto hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in De Soto then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in De Soto?
The cheapest hotel in De Soto is $60. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in De Soto?
There are 203 hotels in De Soto on Travelocity.
What are the best hotels in De Soto?
De Soto has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in De Soto for you!
When is the best time to visit De Soto?
If you want the joy of a fun-filled trip in peak season, visit De Soto during March, April and May. If you'd prefer the peace of off-season, book a stay during quieter months, such as June, October and November.
When is the cheapest time to stay in De Soto?
Based on historic data is usually the cheapest month to visit De Soto. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in De Soto?
There are multiple hotels in De Soto that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to De Soto. We have plenty of kid-friendly hotels in De Soto to choose from on Travelocity!
Why book a hotel in De Soto through Travelocity?
Because we have the top hotels in De Soto! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in De Soto on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent De Soto hotel reviews by fellow wanderers

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Perfect trip!!! I can’t wait to go back when it gets colder outside :)"
A verified traveler stayed at Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Explore More Ways to Travel with Travelocity