Book Hotels in De Soto, MO
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Top De Soto hotels

Gated 35-Acre De Soto Estate: Pool, Lake & Patio!
"Hosts were responsive and very helpful! We had a larger group and it fit everyone comfortably all of the amenities made it so much fun! Great property and would definitely recommend!"
Reviewed on Oct 11, 2026

Secluded cabin on private property
"The perfect getaway place. Fall colors, quiet surroundings and beautifully decorated cabin. The thoughtful hosts have created the best possible stay imaginable."
Reviewed on Oct 29, 2026

82 Acre Hobby Farm with Lincoln Log Cabin
"Very clean and decorated for Halloween. Nothing spooky, just sweet. Very rural (what we were going for!) but close to De Soto and Crystal City MO. Had deer (5) and wild turkey (2) each morning. The entire space is a loft, but easy to climb the stairs. Had a great time."
Reviewed on Oct 12, 2026

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
"Limpio,muy fácil el check in cómodo y limpio."
Reviewed on Nov 2, 2026

Drury Inn & Suites St. Louis Arnold
"The hotel was very well kept and clean. The staff were very friendly and helpful. The amenities were great."
Reviewed on Nov 9, 2026

Comfort Inn Festus - St Louis South
"We arrived we noticed that the stove was dirty. There were no dishes available. The dishes that were available were incomplete. It was a crockpot with no cooker no lid. There were no towels for drying our bodies."
Reviewed on Nov 9, 2026

Pear Tree Inn St. Louis Arnold

Baymont Inn and Suites by Wyndham Farmington, MO

Crown Pointe Lodge, BW Signature Collection
De Soto Hotel & Travel Guide\n
Dreaming about exploring De Soto? Travelocity has no hotels and apartments, however, there are 4 places to rest and relax within an easy drive of De Soto.
The nearest Travelocity-listed accommodation is the Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, Missouri, 9 miles (15 kilometers) from the middle of De Soto. Another Travelocity accommodation option is the Lexington Inn - Shalimar Plaza & Conference Center, situated in Missouri, 10 miles (15 kilometers) from the middle of De Soto.
The Comfort Inn is 10 miles (15 kilometers) outside the city center of De Soto. An alternative accommodation option is the Super 8 Pevely, which can be found approximately 14 miles (22 kilometers) away. The Super 8 Potosi Mo as well as the Super 8 Bonne Terre are two other Travelocity-listed accommodation options worth checking out around De Soto.
There are various Travelocity-registered hotels in Pilot Knob, which is situated 35 miles (55 kilometers) south of De Soto. The Fort Davidson Hotel and Shepherd Mountain Inn are a few of the establishments here.
Make sure you get your fix of local sport by making the journey to Busch Stadium, which is 40 miles (64 kilometers) to the northeast of De Soto. Enlightened travelers wanting to find a Travelocity-listed room near to the action can choose from the Four Seasons Hotel St Louis or the Grand Center Inn.
Lambert-St. Louis International Airport is a practical arrival point for flights, and is situated 45 miles (72 kilometers) away from De Soto. Travelocity-listed hotels close to Lambert-St. Louis International Airport include Marriott St. Louis Airport and Holiday Inn St. Louis-Airport.
Frequently asked questions
Recent De Soto hotel reviews by fellow wanderers

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
"The hotel is kept up beautifully and personnel were very welcoming and helpful. The breakfast was enjoyable and fresh which we really appreciated!"
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