Defiance Vacation Packages 2026 from $495

Defiance flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

21C Museum Hotel St Louis

Downtown West

$495

per person

Apr 17 - Apr 20

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Enjoy the gym and conveniences like a 24-hour front desk and concierge services.

Hotel Saint Louis, Autograph Collection

Downtown St. Louis

$611

per person

Apr 17 - Apr 20

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. There's a bar/lounge on site, and laundry facilities and concierge services are also provided.

The Cheshire

$566

per person

Apr 17 - Apr 20

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal outdoor pool and free English breakfast each morning.

Landing Apartments - Eureka

$1,099

per person

Mar 29 - Apr 3

found 1 day ago

Roundtrip non-stop flight included

Akron (CAK) to St. Louis (STL)

This aparthotel features an outdoor pool and a gym. Guests will appreciate free perks like free self parking and WiFi in public areas. A virtual front desk are provided for your convenience.

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Grand Center

$496

per person

Apr 17 - Apr 20

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. There's a rooftop terrace on site, and a 24-hour front desk and a snack bar/deli are also provided.

Top Defiance hotels deals

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

1088 South Highway Drive Fenton MO

Free Cancellation

Reserve now, pay when you stay

$89 nightly

$103 total

Feb 10 - Feb 11

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Pool

Hot Tub

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive Maryland Heights MO

Free Cancellation

Reserve now, pay when you stay

$142 nightly

$166 total

Feb 16 - Feb 17

Total with taxes and fees

A casino, 7 restaurants, and a 24-hour gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, express check-out, and free airport shuttle. Relax with a drink at one of the 3 bars/lounges and enjoy perks like free self parking.

The Wildwood Hotel

2801 Fountain Pl Wildwood MO

Free Cancellation

Reserve now, pay when you stay

$98 nightly

$114 total

Feb 12 - Feb 13

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

Free Cancellation

Reserve now, pay when you stay

$184 nightly

$215 total

Mar 9 - Mar 10

Total with taxes and fees

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside bar.

Courtyard by Marriott St Louis Creve Coeur

828 N New Ballas Rd St. Louis MO

Free Cancellation

Reserve now, pay when you stay

$114 nightly

$133 total

Feb 20 - Feb 21

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 2 conference rooms, free WiFi in public areas, and express check-out. Free self parking, a coffee shop, and a snack bar/deli are also offered.

Pet friendly

Parking included

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

13639 Riverport Dr Maryland Heights MO

Free Cancellation

Reserve now, pay when you stay

$67 nightly

$78 total

Feb 19 - Feb 20

Total with taxes and fees

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

St. Louis Union Station

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game.

Busch Stadium

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's fascinating museums or attend a baseball game.

Gateway Arch

Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.

Frequently asked questions

How much are vacation packages to Defiance?

Treat yourself to a one-of-a-kind experience in Defiance with a vacation package starting from just $495. Organizing your hotels, tours and flights with Travelocity is a piece of cake. What's more, our vacation deals will leave you with extra cash for loads of fun times.

Where can I get the best vacation package deals for Defiance?

It's difficult to beat Travelocity when it comes to piecing together your Defiance package deal. There are as many as 400 partner airlines and 1,000,000 properties around the world to choose from. Secure your trip now and get ready to cross another amazing place off your travel bucket list.

Why should I purchase my Defiance vacation package with Travelocity?

From our 24/7 customer care to our range of fantastic destinations, we're committed to fulfilling your travel desires. All you'll have to do is click and book — our Price Match Guarantee will make sure you score the best price.

Can I save on my Defiance car rental if I bundle it with my hotel or flight?

With a Defiance vacation package, you can bundle your hotel, car and flight bookings and save some serious money. If you'd love to discover the best of this wonderful part of the world, why not head to Busch Stadium? This popular attraction is 30 mi from Defiance. With your own rental car, you'll be there before you know it.

Which airport is best for Defiance?

Lambert-St. Louis Intl. Airport (STL) is the top airport for those flying to Defiance. Once you touch down, you'll find yourself 25 mi east of the downtown area.

What is there to do in Defiance?

There is a certain magic in the air as you stroll the streets of Defiance. Chandler Hill Vineyards and Historic Daniel Boone Home and Heritage Center are just two famous sights that make this city so popular, so put them at the top of your must-see list.

Where should I stay when visiting Defiance?

The BACKYARD OASIS! Cozy and charming 60s Brick ranch with relaxing gazebo over pond is recommended by many travelers. Book soon to avoid missing out.