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Tonight Dec 12 - Dec 13
This weekend Dec 13 - Dec 15
Next weekend Dec 20 - Dec 22

Most Frequently Booked Defiance Hotels

$84
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5.0 777 Casino Center Drive, Maryland Heights, MO
3.8/5
(65 Reviews)
This hotel features a casino, a nightclub, and a 24-hour fitness center. Traveling on business? Take advantage of the free WiFi in public areas, express check-out, and free airport shuttle. Relax with a drink at one of the 3 bars/lounges and enjoy perks like free self parking.
 
$111
Ameristar Casino Resort and Spa (St. Charles)

Ameristar Casino Resort and Spa (St. Charles)

4.5 out of 5.0 1 Ameristar Blvd, St. Charles, MO
3.6/5
(14 Reviews)
This luxury hotel features a casino, a full-service spa, and a nightclub. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free valet parking. Free self parking is free for guests, and you can enjoy a meal in one of the 7 restaurants.
 
$68
Wingate by Wyndham St. Charles MO

Wingate by Wyndham St. Charles MO

3.0 out of 5.0 32 Research Park Circle, St. Charles, MO
4.1/5
(16 Reviews)
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the 2 conference rooms, as well as the 24-hour business center and free WiFi in public areas. Enjoy the 24-hour fitness center and free perks like buffet breakfast and free self parking.
 
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How much is a hotel room in Defiance?

Hotels in Defiance start at $68 per night. Prices and availability subject to change. Additional terms may apply.

Defiance Hotel & Travel Guide

There isn't a big range of places to base yourself on Travelocity within a 6-mile (10-kilometer) distance of downtown Defiance. We recommend you book as soon as you're ready if you want to stay close to the action.

The Holiday Inn St. Louis West Six Flags, Missouri, which is the closest Travelocity-listed place to stay, sits 13 miles (21 kilometers) from downtown Defiance. Instead, you could think about the Residence Inn By Marriott St Louis Chesterfield, located in Missouri, which is 14 miles (22 kilometers) from the town center.

6 miles (10 kilometers) away from the heart of Defiance, you will find the Staybridge Suites O'Fallon Chesterfield. Alternatively, the Residence Inn by Marriott O'Fallon is 6 miles (10 kilometers) away. Some other options in the Defiance area include the Holiday Inn Express St. Louis West - O'Fallon and the Hilton Garden Inn St. Louis/O'Fallon.

If you have the time, why not broaden your horizons and get to know the other sights located around St. Louis - Northeast Missouri while you are in Defiance? Photographers will love St. Louis - Northeast Missouri's prairies. While you're at it, go to a few of its history museums. Sporty visitors may also try mountain biking, hiking and cycling in the region.

Downtown St. Louis is 30 miles (52 kilometers) to the east of Defiance and boasts Old Post Office and Scott Joplin House State Historic Site. The Four Seasons Hotel St Louis and Grand Center Inn are some of the great hotel choices in Downtown St. Louis. Or, you could stay in North MetroEast, 45 miles (69 kilometers) to the east of Defiance, where you can pick from the Hampton Inn Suites St LouisEdwardsville and Comfort Inn and Conference Center. If you're staying in North MetroEast, set aside some time to check out the Gardens at SIUE and Edwardsville Arts Center.

If enjoying sport is never far from your mind, pay a visit to Busch Stadium, located 35 miles (53 kilometers) to the east of Defiance. Book a hotel surrounded by the sporting action at the The Westin St. Louis or the Embassy Suites St. Louis - Downtown.

If you are planning on arriving through Lambert-St. Louis International Airport, you might like to stay at Marriott St. Louis Airport, or Holiday Inn St. Louis-Airport, both of which are a short distance away.


Recent Defiance Hotel Reviews By Fellow Wanderers


*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.