Book Hotels in Defiance, MO

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Top Defiance hotels

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

3 out of 5
355 Chesterfield Ctr Chesterfield MO
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $151 total per night from Aug 30 to Aug 31
$151 total
Aug 30 - Aug 31
Total with taxes and fees
This hotel features an outdoor pool, an indoor pool, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
"The staff were very pleasant. The breakfast and dinners were great. Room was very clean,"

Reviewed on Aug 17, 2026

Opens in a new windowDrury Plaza Hotel St. Louis Chesterfield
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $92 total per night from Sep 7 to Sep 8
$92 total
Sep 7 - Sep 8
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"Nice classy hotel..right next to police station...very secure place to be!"

Reviewed on Aug 16, 2026

Opens in a new windowThe Wildwood Hotel
Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

4 out of 5
1335 S Lindbergh Blvd Frontenac MO
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $171 total per night from Aug 30 to Aug 31
$171 total
Aug 30 - Aug 31
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"My second time staying there I absolutely love it"

Reviewed on Aug 17, 2026

Opens in a new windowHilton St. Louis Frontenac
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $146 total per night from Sep 2 to Sep 3
$146 total
Sep 2 - Sep 3
Total with taxes and fees
A casino, 7 restaurants, and a 24-hour gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...
"Smell of fish in the hall outside room. Otherwise great."

Reviewed on Aug 15, 2026

Opens in a new windowHollywood Casino & Hotel St. Louis
Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

3 out of 5
1100 S Highway Dr Fenton MO
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $97 total per night from Aug 31 to Sep 1
$97 total
Aug 31 - Sep 1
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"Staff was fine. The bed was comfortable. The room was carpeted but the carpet was sticky and could really use a deep cleaning. We found a flea in the room and then learned that the hotel was pet friendly so I suspect that was the reason. Just one flea, no signs of any severe infestation. Convenient ..."

Reviewed on Aug 17, 2026

Opens in a new windowWingate by Wyndham St. Louis/Fenton Route 66
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

2.5 out of 5
1970 Craig Rd Maryland Heights MO
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $79 total per night from Aug 23 to Aug 24
$79 total
Aug 23 - Aug 24
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. ...
"Roaches, no housekeeping! Smelled bad very dissatisfied"

Reviewed on Aug 17, 2026

Opens in a new windowDays Inn and Suites by Wyndham St. Louis/Westport Plaza
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $109 total per night from Aug 18 to Aug 19
$109 total
Aug 18 - Aug 19
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Opens in a new windowHeritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Drury Plaza Hotel St. Louis Creve Coeur

Drury Plaza Hotel St. Louis Creve Coeur

3 out of 5
11980 Olive Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$136 nightly
The price is $158 total per night from Sep 16 to Sep 17
$158 total
Sep 16 - Sep 17
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Opens in a new windowDrury Plaza Hotel St. Louis Creve Coeur
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 out of 5
1147 Technology Drive O'Fallon MO
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $93 total per night from Sep 7 to Sep 8
$93 total
Sep 7 - Sep 8
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Opens in a new windowSleep Inn & Suites O'Fallon MO - Technology Drive
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See all available properties in Defiance
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Defiance Hotel & Travel Guide\n

There isn't a big range of places to base yourself on Travelocity within a 6-mile (10-kilometer) distance of downtown Defiance. We recommend you book as soon as you're ready if you want to stay close to the action.

The Holiday Inn St. Louis West Six Flags, Missouri, which is the closest Travelocity-listed place to stay, sits 13 miles (21 kilometers) from downtown Defiance. Instead, you could think about the Residence Inn By Marriott St Louis Chesterfield, located in Missouri, which is 14 miles (22 kilometers) from the town center.

6 miles (10 kilometers) away from the heart of Defiance, you will find the Staybridge Suites O'Fallon Chesterfield. Alternatively, the Residence Inn by Marriott O'Fallon is 6 miles (10 kilometers) away. Some other options in the Defiance area include the Holiday Inn Express St. Louis West - O'Fallon and the Hilton Garden Inn St. Louis/O'Fallon.

If you have the time, why not broaden your horizons and get to know the other sights located around St. Louis - Northeast Missouri while you are in Defiance? Photographers will love St. Louis - Northeast Missouri's prairies. While you're at it, go to a few of its history museums. Sporty visitors may also try mountain biking, hiking and cycling in the region.

Downtown St. Louis is 30 miles (52 kilometers) to the east of Defiance and boasts Old Post Office and Scott Joplin House State Historic Site. The Four Seasons Hotel St Louis and Grand Center Inn are some of the great hotel choices in Downtown St. Louis. Or, you could stay in North MetroEast, 45 miles (69 kilometers) to the east of Defiance, where you can pick from the Hampton Inn Suites St LouisEdwardsville and Comfort Inn and Conference Center. If you're staying in North MetroEast, set aside some time to check out the Gardens at SIUE and Edwardsville Arts Center.

If enjoying sport is never far from your mind, pay a visit to Busch Stadium, located 35 miles (53 kilometers) to the east of Defiance. Book a hotel surrounded by the sporting action at the The Westin St. Louis or the Embassy Suites St. Louis - Downtown.

If you are planning on arriving through Lambert-St. Louis International Airport, you might like to stay at Marriott St. Louis Airport, or Holiday Inn St. Louis-Airport, both of which are a short distance away.

Frequently asked questions

What are the top kid-friendly hotels in Defiance?
Family getaways are where lifelong memories are made, but it's no secret that traveling with young ones can be difficult. These kid-friendly Defiance hotels come with perks designed to keep guests of all ages comfortable and happy: The Ruebling House Historic Defiance Apartment! will help make your getaway the best one yet. It comes with plenty of nice little touches, such as free WiFi and extra bedding. Otherwise, spend your Defiance trip at 'The Reubling House' - Modern-Rustic Cabin!. Make the most of a barbecue grill, internet access and more here.
Where can I find cheap hotels in Defiance?
At Travelocity you'll find really nice hotels in Defiance at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Defiance rather than in Defiance. We may find you even better rates, too.
How do I find the best Defiance hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Defiance then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Defiance?
The cheapest hotel in Defiance is $79. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Defiance?
There are 878 hotels in Defiance on Travelocity.
What are the best hotels in Defiance?
Defiance has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Defiance for you!
When is the best time to visit Defiance?
If you want the joy of a fun-filled trip in peak season, visit Defiance during March, April and May. If you'd prefer the peace of off-season, book a stay during quieter months, such as December, January and February.
When is the cheapest time to stay in Defiance?
Based on historic data is usually the cheapest month to visit Defiance. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Defiance?
There are multiple hotels in Defiance that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Defiance. We have plenty of kid-friendly hotels in Defiance to choose from on Travelocity!
Why book a hotel in Defiance through Travelocity?
Because we have the top hotels in Defiance! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Defiance on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Defiance hotel reviews by fellow wanderers

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"The staff were very pleasant. The breakfast and dinners were great. Room was very clean,"
A verified traveler stayed at Drury Plaza Hotel St. Louis Chesterfield
Drury Plaza Hotel St. Louis Chesterfield

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