Book Hotels in Defiance, MO

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Top Defiance hotels

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $107 total per night from Nov 2 to Nov 3
$107 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"Room was clean, yet picures and description are a bit deceiving. Overall, stay was good and would come back again."

Reviewed on Oct 4, 2026

Opens in a new windowThe Wildwood Hotel
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
$183 nightly
The price is $214 total per night from Oct 12 to Oct 13
$214 total
Oct 12 - Oct 13
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside ...
"Easy parking, friendly staff, and large rooms were the highlights of Ameristar. I picked this hotel for my last night in St. Louis before a depressingly early flight. At 10 minutes to the airport, it was a very easy morning. The casino was an added bonus, giving me a way to unwind before my time ..."

Reviewed on Oct 4, 2026

Opens in a new windowAmeristar Casino Resort and Spa
Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

3 out of 5
15431 Conway Rd Chesterfield MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $114 total per night from Nov 1 to Nov 2
$114 total
Nov 1 - Nov 2
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free ...
"The only complaint is out dead bolt got stuck so it was hard to close our door"

Reviewed on Oct 4, 2026

Opens in a new windowSonesta ES Suites St. Louis - Chesterfield
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $103 total per night from Nov 1 to Nov 2
$103 total
Nov 1 - Nov 2
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"It’s a former Drury Inn property so it’s built well and pretty quiet. Room was clean and comfortable. A bit on the small size but not cramped."

Reviewed on Oct 4, 2026

Opens in a new windowHeritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

3 out of 5
13639 Riverport Dr Maryland Heights MO
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $83 total per night from Oct 27 to Oct 28
$83 total
Oct 27 - Oct 28
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
"Clean and quiet place to walk from a concert at the theater. No drinking and driving"

Reviewed on Oct 4, 2026

Opens in a new windowLarkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

3 out of 5
1100 S Highway Dr Fenton MO
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $91 total per night from Oct 18 to Oct 19
$91 total
Oct 18 - Oct 19
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free full breakfast, free WiFi, and free self parking. Business travelers can take advantage of the express ...
"Good channel sel"

Reviewed on Oct 4, 2026

Opens in a new windowWingate by Wyndham St. Louis/Fenton Route 66
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
$108 nightly
The price is $127 total per night from Nov 1 to Nov 2
$127 total
Nov 1 - Nov 2
Total with taxes and fees
A casino, 7 restaurants, and a 24-hour gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...
Opens in a new windowHollywood Casino & Hotel St. Louis
Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters

3 out of 5
170 Mid Rivers Mall Circle St. Peters MO
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $136 total per night from Nov 1 to Nov 2
$136 total
Nov 1 - Nov 2
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Opens in a new windowDrury Inn & Suites St. Louis St. Peters
Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

3 out of 5
355 Chesterfield Ctr Chesterfield MO
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $151 total per night from Oct 11 to Oct 12
$151 total
Oct 11 - Oct 12
Total with taxes and fees
This hotel features an outdoor pool, an indoor pool, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
Opens in a new windowDrury Plaza Hotel St. Louis Chesterfield
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Defiance Hotel & Travel Guide\n

There isn't a big range of places to base yourself on Travelocity within a 6-mile (10-kilometer) distance of downtown Defiance. We recommend you book as soon as you're ready if you want to stay close to the action.

The Holiday Inn St. Louis West Six Flags, Missouri, which is the closest Travelocity-listed place to stay, sits 13 miles (21 kilometers) from downtown Defiance. Instead, you could think about the Residence Inn By Marriott St Louis Chesterfield, located in Missouri, which is 14 miles (22 kilometers) from the town center.

6 miles (10 kilometers) away from the heart of Defiance, you will find the Staybridge Suites O'Fallon Chesterfield. Alternatively, the Residence Inn by Marriott O'Fallon is 6 miles (10 kilometers) away. Some other options in the Defiance area include the Holiday Inn Express St. Louis West - O'Fallon and the Hilton Garden Inn St. Louis/O'Fallon.

If you have the time, why not broaden your horizons and get to know the other sights located around St. Louis - Northeast Missouri while you are in Defiance? Photographers will love St. Louis - Northeast Missouri's prairies. While you're at it, go to a few of its history museums. Sporty visitors may also try mountain biking, hiking and cycling in the region.

Downtown St. Louis is 30 miles (52 kilometers) to the east of Defiance and boasts Old Post Office and Scott Joplin House State Historic Site. The Four Seasons Hotel St Louis and Grand Center Inn are some of the great hotel choices in Downtown St. Louis. Or, you could stay in North MetroEast, 45 miles (69 kilometers) to the east of Defiance, where you can pick from the Hampton Inn Suites St LouisEdwardsville and Comfort Inn and Conference Center. If you're staying in North MetroEast, set aside some time to check out the Gardens at SIUE and Edwardsville Arts Center.

If enjoying sport is never far from your mind, pay a visit to Busch Stadium, located 35 miles (53 kilometers) to the east of Defiance. Book a hotel surrounded by the sporting action at the The Westin St. Louis or the Embassy Suites St. Louis - Downtown.

If you are planning on arriving through Lambert-St. Louis International Airport, you might like to stay at Marriott St. Louis Airport, or Holiday Inn St. Louis-Airport, both of which are a short distance away.

Frequently asked questions

What are the top kid-friendly hotels in Defiance?
Family getaways are where lifelong memories are made, but it's no secret that traveling with young ones can be difficult. These kid-friendly Defiance hotels come with perks designed to keep guests of all ages comfortable and happy: The Ruebling House Historic Defiance Apartment! will help make your getaway the best one yet. It comes with plenty of nice little touches, such as free WiFi and extra bedding. Otherwise, spend your Defiance trip at 'The Reubling House' - Modern-Rustic Cabin!. Make the most of a barbecue grill, internet access and more here.
Where can I find cheap hotels in Defiance?
At Travelocity you'll find really nice hotels in Defiance at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Defiance rather than in Defiance. We may find you even better rates, too.
How do I find the best Defiance hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Defiance then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Defiance?
The cheapest hotel in Defiance is $83. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Defiance?
There are 893 hotels in Defiance on Travelocity.
What are the best hotels in Defiance?
Defiance has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Defiance for you!
When is the best time to visit Defiance?
If you want the joy of a fun-filled trip in peak season, visit Defiance during March, April and May. If you'd prefer the peace of off-season, book a stay during quieter months, such as December, January and February.
When is the cheapest time to stay in Defiance?
Based on historic data is usually the cheapest month to visit Defiance. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Defiance?
There are multiple hotels in Defiance that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Defiance. We have plenty of kid-friendly hotels in Defiance to choose from on Travelocity!
Why book a hotel in Defiance through Travelocity?
Because we have the top hotels in Defiance! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Defiance on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Defiance hotel reviews by fellow wanderers

Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"The only complaint is out dead bolt got stuck so it was hard to close our door"
A verified traveler stayed at Sonesta ES Suites St. Louis - Chesterfield
Sonesta ES Suites St. Louis - Chesterfield

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