Book Hotels in Brussels, IL
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Top Brussels hotels

Drury Plaza Hotel St. Louis Chesterfield
Nice property, friendly staff, clean/comfy room and good breakfast. My only complaint is that the rooms on the front of the property face Interstate 64 and the road noise is extremely loud.
Reviewed on Apr 21, 2026

Pear Tree Inn St. Louis Airport
Check in was easy and the room was clean and inviting after 12 hours of flying.
Reviewed on Apr 21, 2026

Drury Inn & Suites St. Louis Airport
Staff was very accommodating. Everyone was so nice. The breakfast was a basic breakfast. No bacon!!! Smh The manager’s reception is something every hotel should have. Just my opinion. The only thing is that next time I’m going to request my room not be right by the elevator. Kids like to knock, run, ...
Reviewed on Apr 21, 2026

Hyatt Select St. Louis Airport
The attention to detail and overall quality of the hotel was outstanding
Reviewed on Apr 20, 2026

Motel 6 Hazelwood, MO
Nice large rooms Could have used. 2nd pillow
Reviewed on Apr 19, 2026

Hollywood Casino & Hotel St. Louis
Didn't get breakfast
Reviewed on Apr 21, 2026

Ameristar Casino Resort and Spa
Room was beautiful. Staff very helpful. Lots of parking.
Reviewed on Apr 21, 2026

Hilton St. Louis Airport
The hotel was
Reviewed on Apr 20, 2026

Renaissance St. Louis Airport Hotel
Brussels Hotel & Travel Guide\n
You may have realized that there are no accommodations options on Travelocity in Brussels. You don't need to stress, because you'll find 2 places to put your feet up an easy drive from Brussels.
The closest Travelocity-listed accommodation option is the Ameristar Casino Resort and Spa, Missouri, 14 miles (22 kilometers) from the downtown core of Brussels. Another handy option is the Embassy Suites St. Louis - St. Charles, situated in Missouri, 13 miles (21 kilometers) from the central area of Brussels.
You could also check out the The Green Tree Inn as well as the Staybridge Suites O'Fallon Chesterfield. The The Green Tree Inn is located only 12 miles (20 kilometers) from central Brussels. The Staybridge Suites O'Fallon Chesterfield, is located just 17 miles (28 kilometers) away. The Residence Inn by Marriott O'Fallon as well as the Sheraton Westport Plaza Hotel St. Louis are other alternative places to book accommodation in Brussels.
Researching so you can go a bit further afield? Southern Illinois has a number of things to see. If you love nature, get ready to discover Southern Illinois's rural landscapes, rolling hills and prairies. You could also venture through its farms. Visitors in this section of United States of America often enjoy rock climbing, hiking and abseiling.
25 miles (40 kilometers) away from Brussels, you will reach Alton, where visitors can enjoy Argosy Casino and Alton Square Mall. The Atrium Hotel and Conference Center and Comfort Inn are just some of the convenient lodging options in Alton. 40 miles (64 kilometers) southeast of Brussels, you'll reach Fairview Heights, which is home to the Holiday Inn St. Louis Fairview Heights and Fairfield Inn by Marriott Fairview Heights. While in Fairview Heights, it's worth visiting the Stonewolf Golf Course and St. Claire Square Mall.
If you can't stop thinking about sport and love attending local games you and your traveling partner should stop by Busch Stadium, which can be found 30 miles (50 kilometers) to the southeast of Brussels. Travelocity customers who would like the ease of booking a bed in the vicinity, reserve a room in the Four Seasons Hotel St Louis or Grand Center Inn.
Lambert-St. Louis International Airport is a primary entry point for those flying to Brussels. It is 19 miles (30 kilometers) from the town center. If you choose to stay nearby, look into Marriott St. Louis Airport or Holiday Inn St. Louis-Airport.
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Recent Brussels hotel reviews by fellow wanderers

Drury Inn & Suites St. Louis St. Peters
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