Explore top 2026 4 Star Hotels in Jeffersonville

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Top Jeffersonville 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$136 nightly
The price is $160 total per night from Nov 22 to Nov 23
$160 total
Nov 22 - Nov 23
Total with taxes and fees
A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Opens in a new windowGalt House Hotel Trademark Collection by Wyndham
The Brown Hotel

The Brown Hotel

4.5 out of 5
335 W Broadway Louisville KY
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $128 total per night from Nov 28 to Nov 29
$128 total
Nov 28 - Nov 29
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...
9.4/10 Exceptional! (1,471 reviews)
"The Brown is my favorite Hotel, but they have taken away the complimentary coffee they have had for years. It now costs five dollars. It may seem petty, but this will definitely influence my next decision to consider staying there."

Reviewed on Nov 9, 2026

Opens in a new windowThe Brown Hotel
Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

4 out of 5
4520 Poplar Level Rd Louisville KY
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $107 total per night from Nov 15 to Nov 16
$107 total
Nov 15 - Nov 16
Total with taxes and fees
This smoke-free hotel features 3 restaurants and 3 bars/lounges. Guests will appreciate free perks like free self parking and WiFi in public areas. A coffee ...
9.6/10 Exceptional! (2,623 reviews)
"Perfect stay for Bourbon and Beyond. Enjoyed the casino a lot before heading to the venue each day. Room is clean, bed is comfortable, appreciated waters already stocked In the fridge. This was our second year there in a row. Didn’t disappoint!"

Reviewed on Nov 10, 2026

Opens in a new windowDerby City Gaming & Hotel - A Churchill Downs Property (Adults Only)
Omni Louisville Hotel

Omni Louisville Hotel

4 out of 5
400 S. 2nd Street Louisville KY
Fully refundableReserve now, pay when you stay
$178 nightly
The price is $209 total per night from Nov 24 to Nov 25
$209 total
Nov 24 - Nov 25
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
Opens in a new windowOmni Louisville Hotel
Louisville Marriott Downtown

Louisville Marriott Downtown

4 out of 5
280 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$168 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Opens in a new windowLouisville Marriott Downtown
Hyatt Regency Louisville

Hyatt Regency Louisville

4 out of 5
320 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $147 total per night from Nov 22 to Nov 23
$147 total
Nov 22 - Nov 23
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.8/10 Excellent! (1,003 reviews)
"Housekeeping knocked"

Reviewed on Nov 8, 2026

Opens in a new windowHyatt Regency Louisville
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

4 out of 5
501 South Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $144 total per night from Nov 23 to Nov 24
$144 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...
9/10 Wonderful! (1,392 reviews)
"Beautiful hotel, great evening reception and delicious made to order breakfast"

Reviewed on Nov 9, 2026

Opens in a new windowEmbassy Suites Louisville Downtown
The Grady

The Grady

4 out of 5
601 W Main St Louisville KY
Fully refundableReserve now, pay when you stay
$153 nightly
The price is $180 total per night from Nov 24 to Nov 25
$180 total
Nov 24 - Nov 25
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.
9.4/10 Exceptional! (1,011 reviews)
"The design is amazing!"

Reviewed on Nov 9, 2026

Opens in a new windowThe Grady
21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 out of 5
700 W Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $184 total per night from Dec 6 to Dec 7
$184 total
Dec 6 - Dec 7
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
Opens in a new window21c Museum Hotel Louisville
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

4 out of 5
101 West Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$202 nightly
The price is $237 total per night from Nov 22 to Nov 23
$237 total
Nov 22 - Nov 23
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.6/10 Exceptional! (519 reviews)
"Excellent location and room!"

Reviewed on Nov 6, 2026

Opens in a new windowHotel Distil, Autograph Collection
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4 Star Hotels Jeffersonville

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Jeffersonville 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Jeffersonville will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Jeffersonville, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Jeffersonville hotel reviews by fellow wanderers

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