Find and compare 3 Star hotels in Southeast Missouri

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Top Southeast Missouri 3 Star hotels

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Dec 1 to Dec 2
$102 total
Dec 1 - Dec 2
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9.4/10 Exceptional! (1,003 reviews)
Clean room and amenities were great

Reviewed on Nov 9, 2025

Opens in a new windowDrury Plaza Hotel Cape Girardeau Conference Center
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3 out of 5
2781 N Westwood Blvd, Poplar Bluff, MO
Fully refundable
$101 nightly
The price is $114 total per night from Nov 23 to Nov 24
$114 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
8.6/10 Excellent! (685 reviews)
I appreciated the quiet room, friendly staff and the included breakfast

Reviewed on Oct 27, 2025

Opens in a new windowHoliday Inn Poplar Bluff by IHG
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $91 total per night from Nov 18 to Nov 19
$91 total
Nov 18 - Nov 19
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
8.8/10 Excellent! (648 reviews)
Thanks

Reviewed on Nov 9, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $110 total per night from Nov 21 to Nov 22
$110 total
Nov 21 - Nov 22
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.4/10 Exceptional! (1,000 reviews)
The room was very clean. The front desk staff were courteous and helpful.

Reviewed on Nov 9, 2025

Opens in a new windowDrury Inn & Suites Sikeston, MO
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3 out of 5
2220 N Westwood Blvd Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Nov 21 to Nov 22
$106 total
Nov 21 - Nov 22
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.2/10 Wonderful! (945 reviews)
The only thing was food was left on the fridge. Otherwise, excellent service and condition!

Reviewed on Nov 14, 2025

Opens in a new windowDrury Inn & Suites Poplar Bluff
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St. Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $131 total per night from Nov 27 to Nov 28
$131 total
Nov 27 - Nov 28
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9.4/10 Exceptional! (462 reviews)
The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us.

Reviewed on Nov 14, 2025

Opens in a new windowCourtyard by Marriott Cape Girardeau Downtown
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Nov 30 to Dec 1
$102 total
Nov 30 - Dec 1
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.4/10 Exceptional! (999 reviews)
Clean and friendly staff!!!

Reviewed on Nov 9, 2025

Opens in a new windowDrury Inn & Suites Cape Girardeau
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3 out of 5
1317 E Highway 84 Hayti MO
$94 nightly
The price is $107 total per night from Nov 23 to Nov 24
$107 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.2/10 Wonderful! (1,001 reviews)
Clean and safe. Very friendly staff.

Reviewed on Nov 12, 2025

Opens in a new windowDrury Inn & Suites Hayti Caruthersville
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $112 total per night from Nov 23 to Nov 24
$112 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
7.8/10 Good! (878 reviews)
One of the quietest hotels I’ve ever stayed in. The staff is amazing as well. The rooms are clean, the beds are comfortable and everything is literally right there. A front desk worker named Jessica helped me out with something going above and beyond. This hotel deserves all the business.

Reviewed on Nov 11, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham Festus - St. Louis South
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane, Jackson, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $95 total per night from Nov 23 to Nov 24
$95 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.6/10 Exceptional! (1,001 reviews)
Nice staff. Clean rooms.

Reviewed on Nov 13, 2025

Opens in a new windowDrury Inn & Suites Jackson MO
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3 Star Hotels Southeast Missouri

Maybe you’ve got to travel for work, or perhaps you’re finally ready to book that much-deserved vacation—regardless, it’s time for you to get on a plane and you’re going to make the most of it. You’ve traveled enough to know how important a comfy bed and room service can be, so booking a hotel with all the amenities you need is a priority.

You can find 3 star hotels in Southeast Missouri that keep you close to all the great sightseeing and activities around the area, or even book a place that’s a bit more secluded, if that’s what you prefer. No matter what you’re looking for—whether you’re all about the location or are invested in on-site perks--Travelocity will help you find the accommodation that works best for you.

When it comes to options, you’ll have them. The Southeast Missouri 3 star hotels give you plenty of choices as far as access to the best areas, and many also offer a breakfast buffet, as well as plenty of other amenities like high-speed Wi-Fi and an on-site pool or spa.

Whatever you’re looking for on your next getaway, browse Travelocity’s big selection of hotels to ensure you get the best possible deal. Book one of the best 3 star hotels in Southeast Missouri today!

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