Find and compare 3 Star hotels in Southeast Missouri

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Top Southeast Missouri 3 Star hotels

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $113 total per night from Feb 22 to Feb 23
$113 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9.6/10 Exceptional! (1,000 reviews)
Clean, great staff

Reviewed on Feb 15, 2026

Opens in a new windowDrury Plaza Hotel Cape Girardeau Conference Center
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3 out of 5
2781 N Westwood Blvd Poplar Bluff MO
Fully refundable
$84 nightly
The price is $95 total per night from Mar 20 to Mar 21
$95 total
Mar 20 - Mar 21
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Opens in a new windowHoliday Inn Poplar Bluff by IHG
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $91 total per night from Feb 19 to Feb 20
$91 total
Feb 19 - Feb 20
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
9/10 Wonderful! (706 reviews)
Nice clean room. The breakfast could be improved but overall a good comfortable stay.

Reviewed on Feb 17, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $107 total per night from Feb 24 to Feb 25
$107 total
Feb 24 - Feb 25
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.4/10 Exceptional! (1,001 reviews)
upgrade to a suite

Reviewed on Feb 16, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3 out of 5
2220 N Westwood Blvd Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Feb 21 to Feb 22
$106 total
Feb 21 - Feb 22
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.2/10 Wonderful! (995 reviews)
Staff was fantastic

Reviewed on Feb 17, 2026

Opens in a new windowDrury Inn & Suites Poplar Bluff
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St. Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $142 total per night from Mar 1 to Mar 2
$142 total
Mar 1 - Mar 2
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9.6/10 Exceptional! (489 reviews)
Amazing stay. Very clean. Staff was wonderful.

Reviewed on Feb 16, 2026

Opens in a new windowCourtyard by Marriott Cape Girardeau Downtown
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Feb 22 to Feb 23
$102 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.4/10 Exceptional! (1,003 reviews)
Friendly staff, great amneties, spotless, relaxing. We always look for Drurys wherever we go.

Reviewed on Feb 15, 2026

Opens in a new windowDrury Inn & Suites Cape Girardeau
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3 out of 5
1317 E Highway 84 Hayti MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $112 total per night from Mar 8 to Mar 9
$112 total
Mar 8 - Mar 9
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.4/10 Exceptional! (1,004 reviews)
Just as expected.

Reviewed on Feb 17, 2026

Opens in a new windowDrury Inn & Suites Hayti Caruthersville
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $113 total per night from Feb 22 to Feb 23
$113 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
8/10 Very Good! (913 reviews)
The staff is awesome

Reviewed on Feb 17, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Festus - St. Louis South
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane Jackson MO
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $85 total per night from Feb 22 to Feb 23
$85 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.6/10 Exceptional! (1,005 reviews)
Great room and awesome staff

Reviewed on Feb 16, 2026

Opens in a new windowDrury Inn & Suites Jackson MO
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3 Star Hotels Southeast Missouri

Maybe you’ve got to travel for work, or perhaps you’re finally ready to book that much-deserved vacation—regardless, it’s time for you to get on a plane and you’re going to make the most of it. You’ve traveled enough to know how important a comfy bed and room service can be, so booking a hotel with all the amenities you need is a priority.

You can find 3 star hotels in Southeast Missouri that keep you close to all the great sightseeing and activities around the area, or even book a place that’s a bit more secluded, if that’s what you prefer. No matter what you’re looking for—whether you’re all about the location or are invested in on-site perks--Travelocity will help you find the accommodation that works best for you.

When it comes to options, you’ll have them. The Southeast Missouri 3 star hotels give you plenty of choices as far as access to the best areas, and many also offer a breakfast buffet, as well as plenty of other amenities like high-speed Wi-Fi and an on-site pool or spa.

Whatever you’re looking for on your next getaway, browse Travelocity’s big selection of hotels to ensure you get the best possible deal. Book one of the best 3 star hotels in Southeast Missouri today!

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