Find and compare 3 Star hotels in Southeast Missouri

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Top Southeast Missouri 3 Star hotels

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Oct 2 to Oct 3
$102 total
Oct 2 - Oct 3
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9.4/10 Exceptional! (1,017 reviews)
"Breakfast and kick-back were excellent. Wish the kick-back hours could be a little longer."

Reviewed on Sep 21, 2025

Opens in a new windowDrury Plaza Hotel Cape Girardeau Conference Center
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $91 total per night from Sep 30 to Oct 1
$91 total
Sep 30 - Oct 1
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
8.8/10 Excellent! (622 reviews)
"Clean room and breakfast area!"

Reviewed on Sep 18, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $103 total per night from Oct 5 to Oct 6
$103 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.4/10 Exceptional! (1,012 reviews)
"Everything was extremely nice"

Reviewed on Sep 22, 2025

Opens in a new windowDrury Inn & Suites Sikeston, MO
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd, Festus, MO
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $126 total per night from Oct 5 to Oct 6
$126 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
7.8/10 Good! (856 reviews)
"Great easy place to stay. Good location."

Reviewed on Sep 20, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham Festus - St. Louis South
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Oct 2 to Oct 3
$102 total
Oct 2 - Oct 3
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.2/10 Wonderful! (998 reviews)
"I like the 5:30 kickback of snacks and drinks at no cost"

Reviewed on Sep 15, 2025

Opens in a new windowDrury Inn & Suites Cape Girardeau
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St., Cape Girardeau, MO
$125 nightly
The price is $142 total per night from Oct 19 to Oct 20
$142 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9.4/10 Exceptional! (450 reviews)
"My husband and I love this hotel. We stay here every single time we are in the area. While it’s a little pricier than a few other options it is definitely worth it for us. The hotel is beautiful and the staff is always very accommodating. Emily and the rest of the staff are so sweet and helpful. ..."

Reviewed on Sep 21, 2025

Opens in a new windowCourtyard by Marriott Cape Girardeau Downtown
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane, Jackson, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $95 total per night from Oct 2 to Oct 3
$95 total
Oct 2 - Oct 3
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.6/10 Exceptional! (1,011 reviews)
"The staff were very helpful. & friendly."

Reviewed on Sep 22, 2025

Opens in a new windowDrury Inn & Suites Jackson MO
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3 out of 5
2220 N Westwood Blvd, Poplar Bluff, MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Oct 2 to Oct 3
$106 total
Oct 2 - Oct 3
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.2/10 Wonderful! (913 reviews)
Weekend Getaway
"The staff was very friendly."

Reviewed on Sep 21, 2025

Opens in a new windowDrury Inn & Suites Poplar Bluff
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3 out of 5
1317 E Highway 84, Hayti, MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $107 total per night from Oct 5 to Oct 6
$107 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
9.2/10 Wonderful! (1,006 reviews)
"Very clean, room was spacious. Breakfast was usual fare, but hot and good, breakfast staff welcoming. Check in staff at midnight was super rude, but check out staff in morning was friendly."

Reviewed on Sep 22, 2025

Opens in a new windowDrury Inn & Suites Hayti Caruthersville
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3 out of 5
2781 N Westwood Blvd, Poplar Bluff, MO
Fully refundable
$97 nightly
The price is $110 total per night from Oct 5 to Oct 6
$110 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
8.6/10 Excellent! (675 reviews)
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Reviewed on Aug 11, 2025

Opens in a new windowHoliday Inn Poplar Bluff by IHG
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3 Star Hotels Southeast Missouri

Maybe you’ve got to travel for work, or perhaps you’re finally ready to book that much-deserved vacation—regardless, it’s time for you to get on a plane and you’re going to make the most of it. You’ve traveled enough to know how important a comfy bed and room service can be, so booking a hotel with all the amenities you need is a priority.

You can find 3 star hotels in Southeast Missouri that keep you close to all the great sightseeing and activities around the area, or even book a place that’s a bit more secluded, if that’s what you prefer. No matter what you’re looking for—whether you’re all about the location or are invested in on-site perks--Travelocity will help you find the accommodation that works best for you.

When it comes to options, you’ll have them. The Southeast Missouri 3 star hotels give you plenty of choices as far as access to the best areas, and many also offer a breakfast buffet, as well as plenty of other amenities like high-speed Wi-Fi and an on-site pool or spa.

Whatever you’re looking for on your next getaway, browse Travelocity’s big selection of hotels to ensure you get the best possible deal. Book one of the best 3 star hotels in Southeast Missouri today!

Recent Southeast Missouri hotel reviews by fellow wanderers