Book Hotels in Wykoff, MN
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Top Wykoff hotels

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $160 total per night from May 31 to Jun 1
$160 total
May 31 - Jun 1
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"The staff at the Hyatt House in Rochester Minnesota was very friendly. The breakfast was great. They had fresh fruit every morning and plain Greek yogurt. The breakfast area was clean and well stocked. My only issue was in our room that there were stains on the sheets. The mattress was comfy and ..."
Reviewed on May 22, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$103 nightly
The price is $119 total per night from May 25 to May 26
$119 total
May 25 - May 26
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"The room was ok, the beds were comfortable. Housekeeping never came even though we requested them in writing; so a 4 night stay with no housekeeping. The common areas were not well maintained, hallways are dark and common staircases look neglected. Good proximity to Mayo, but we will not stay here ..."
Reviewed on May 22, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from May 23 to May 24
$131 total
May 23 - May 24
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
"I will not stay there again."
Reviewed on May 21, 2026

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
1125 2nd St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $113 total per night from Jun 12 to Jun 13
$113 total
Jun 12 - Jun 13
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
"Yes very nice"
Reviewed on May 19, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from May 23 to May 24
$146 total
May 23 - May 24
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"The best part of our stay was the staff. Everyone was friendly and helpful. Parking was rough. The garage next to the hotel was full and I did not want to pay $34 for valet parking. The next nearest garage was a couple blocks away. With all the construction, the hotel has provided great unloading ..."
Reviewed on May 20, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
1517 16th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from May 27 to May 28
$108 total
May 27 - May 28
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Bring the family and enjoy the children's pool, waterslide, and arcade/game room. Enjoy the ...
"The room was clean, the staff were very friendly and helpful and the pool area is amazing. I stayed for almost 2 weeks and I will be booking here again if I need to come back!"
Reviewed on May 20, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from May 23 to May 24
$152 total
May 23 - May 24
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
"Room was clean, the breakfast was very good, only thing we didn't like was the underground parking."
Reviewed on May 20, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $87 total per night from Jun 14 to Jun 15
$87 total
Jun 14 - Jun 15
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
"Needs work…beds were comfy tho"
Reviewed on May 21, 2026

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Fully refundable
$103 nightly
The price is $118 total per night from May 23 to May 24
$118 total
May 23 - May 24
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Wykoff hotel reviews by fellow wanderers

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3 out of 5
Posted 11 hours ago
Travelocity Verified Review
"The room was ok, the beds were comfortable. Housekeeping never came even though we requested them in writing; so a 4 night stay with no housekeeping. The common areas were not well maintained, hallways are dark and common staircases look neglected. Good proximity to Mayo, but we will not stay here again if we have other options."
A verified traveler stayed at Hotel Indigo Rochester – Mayo Clinic Area by IHG
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