Book Hotels in Wykoff, MN
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Top Wykoff hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Fully refundable
$116 nightly
The price is $133 total per night from Jan 31 to Feb 1
$133 total
Jan 31 - Feb 1
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Great
Reviewed on Jan 9, 2026

Spark by Hilton Rochester South
4165 Maine Ave SE Rochester MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Jan 25 to Jan 26
$84 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free perks ...
Clean, quiet and a spacious room at a reasonable price.
Reviewed on Jan 10, 2026

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$133 nightly
The price is $153 total per night from Jan 31 to Feb 1
$153 total
Jan 31 - Feb 1
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Was supposed to have food available and there wasn't due to not having a cook. Nobody said anything at check-in, wasn't listed on their website. Cost extra to have food delivered, which we were trying to avoid.
Reviewed on Jan 12, 2026

Aspen Suites
1211 2nd Street Rochester MN
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $149 total per night from Feb 1 to Feb 2
$149 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
I stayed here for 2+ months this past summer when my daughter had her heart transplant and they became like family to me and they helped me get through it. We were back this past week for my daughters check up and as usual everything and everyone was wonderful. The breakfast food was fresh and delicious. ...
Reviewed on Jan 16, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$85 nightly
The price is $98 total per night from Jan 30 to Jan 31
$98 total
Jan 30 - Jan 31
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Need to change up the beding. Not the best. Comforter to hold.
Reviewed on Jan 14, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Jan 18 to Jan 19
$146 total
Jan 18 - Jan 19
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
The employees were very nice and polite.
Reviewed on Jan 14, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $87 total per night from Jan 22 to Jan 23
$87 total
Jan 22 - Jan 23
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
The room was spotless, the staff very friendly, breakfast more than needed, coffee the best of anyplace we've stayed.
Reviewed on Jan 13, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $151 total per night from Jan 24 to Jan 25
$151 total
Jan 24 - Jan 25
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
It is great but very noisy next to active construction. Very hard to rest in between appointments. BRING EAR PLUGS.
Reviewed on Jan 15, 2026

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
4353 Canal Pl SE Rochester MN
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $88 total per night from Jan 18 to Jan 19
$88 total
Jan 18 - Jan 19
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of the ...
Clean and nice rooms
Reviewed on Jan 12, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Wykoff hotel reviews by fellow wanderers

Aspen Suites
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"I stayed here for 2+ months this past summer when my daughter had her heart transplant and they became like family to me and they helped me get through it. We were back this past week for my daughters check up and as usual everything and everyone was wonderful. The breakfast food was fresh and delicious. The staff is the best ever. The room was spotless and so comfortable. The entire place is homey and cozy. It is our home away from home. Thank you so much guys ♥️"
A verified traveler stayed at Aspen Suites
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