Book Hotels in Wykoff, MN
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Top Wykoff hotels

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $128 total per night from Nov 27 to Nov 28
$128 total
Nov 27 - Nov 28
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"Clean and nice hotel. Excellent breakfast."
Reviewed on Nov 13, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from Nov 14 to Nov 15
$131 total
Nov 14 - Nov 15
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
"I love the swimming pool"
Reviewed on Nov 13, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $165 total per night from Dec 12 to Dec 13
$165 total
Dec 12 - Dec 13
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
"Very convenient to Mayo Clinic using subway access from hotel. No need to walk outside."
Reviewed on Nov 13, 2026

Med City Inn & Suites - Mayo Clinic Area
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Dec 13 to Dec 14
$84 total
Dec 13 - Dec 14
Total with taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
"Old place. Rooms were decent and show some updating. Common areas real run down. Hot tub was non-operational and that was a big reason why I booked the stay."
Reviewed on Nov 11, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $178 total per night from Nov 26 to Nov 27
$178 total
Nov 26 - Nov 27
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Dec 6 to Dec 7
$84 total
Dec 6 - Dec 7
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...

Brentwood Inn & Suites
123 Fourth Ave. NW Rochester MN
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $138 total per night from Nov 14 to Nov 15
$138 total
Nov 14 - Nov 15
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast and free WiFi. Business travelers can take advantage of the 24-hour business ...

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$97 nightly
The price is $112 total per night from Nov 28 to Nov 29
$112 total
Nov 28 - Nov 29
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...

The Berkman
217 14th Ave SW Rochester MN
Fully refundableReserve now, pay when you stay
$210 nightly
The price is $241 total per night from Dec 1 to Dec 2
$241 total
Dec 1 - Dec 2
Total with taxes and fees
This aparthotel features a gym and a seasonal outdoor pool. Enjoy the a rooftop terrace and perks like free WiFi. Self parking, a 24-hour business center, and ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Wykoff hotel reviews by fellow wanderers

Kahler Inn and Suites - Mayo Clinic Area
5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Very convenient to Mayo Clinic using subway access from hotel. No need to walk outside."
A verified traveler stayed at Kahler Inn and Suites - Mayo Clinic Area
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