Book Hotels in Wykoff, MN
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top Wykoff hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Fully refundable
$116 nightly
The price is $133 total per night from Apr 3 to Apr 4
$133 total
Apr 3 - Apr 4
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Very nice place to stay at and very close to the mayo clinic
Reviewed on Mar 12, 2026

Spark by Hilton Rochester South
4165 Maine Ave SE Rochester MN
Fully refundableReserve now, pay when you stay
$69 nightly
The price is $79 total per night from Mar 22 to Mar 23
$79 total
Mar 22 - Mar 23
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free perks ...
Quick check in, nice room. Insulation is lacking so be prepared to hear your neighbors. Breakfast has a lot of high carb options, so if you’re looking for a protein breakfast, you’ll likely need to eat offsite.
Reviewed on Mar 14, 2026

Aspen Suites
1211 2nd Street Rochester MN
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $175 total per night from Mar 18 to Mar 19
$175 total
Mar 18 - Mar 19
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Great amenities
Reviewed on Mar 13, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$90 nightly
The price is $104 total per night from Apr 3 to Apr 4
$104 total
Apr 3 - Apr 4
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Nice room
Reviewed on Mar 10, 2026

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
1125 2nd St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Mar 21 to Mar 22
$108 total
Mar 21 - Mar 22
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Pros: affordable, staff willing to help and breakfast Cons: bathroom flooring buckling, no pool towels (asked for some but out), hot tub was warm but not working and stains on the furniture.
Reviewed on Mar 11, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Mar 15 to Mar 16
$146 total
Mar 15 - Mar 16
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
For the price parking should be cheaper and breakfast should be free, especially since most people are staying here for medical reasons
Reviewed on Mar 13, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
1517 16th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $91 total per night from Mar 16 to Mar 17
$91 total
Mar 16 - Mar 17
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Bring the family and enjoy the children's pool, waterslide, and arcade/game room. Enjoy the ...
The entire property smelled strongly of chlorine from the pool. That included in our room. My friend had irritated eyes and sinuses from it. I had a bad headache. It's a nice property with a great staff, but something needs to be done about the smell.
Reviewed on Mar 13, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Mar 22 to Mar 23
$84 total
Mar 22 - Mar 23
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
Good place to stay
Reviewed on Mar 12, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from Mar 15 to Mar 16
$152 total
Mar 15 - Mar 16
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
Very clean, nice breakfast and convenient to the clinic via walking subway.
Reviewed on Mar 13, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Wykoff hotel reviews by fellow wanderers

Spark by Hilton Rochester South
5 out of 5
Posted 2 hours ago
Travelocity Verified Review
"Quick check in, nice room. Insulation is lacking so be prepared to hear your neighbors. Breakfast has a lot of high carb options, so if you’re looking for a protein breakfast, you’ll likely need to eat offsite. "
A verified traveler stayed at Spark by Hilton Rochester South
Explore More Ways to Travel with Travelocity
- Hotels near Rochester Community and Technical College
- Hotels near Apache Mall
- Hotels near Old Barn Resort Course
- St. Charles Hotels
- Hotels near Olmsted County Fairgrounds
- Rochester Hotels
- Hotels near Forestville Mystery Cave State Park
- Hotels near Mayo Clinic
- Hotels near Niagara Cave
- B&B in Stewartville
- Cottages in Stewartville
- Extended Stay Hotels in Stewartville
- Stewartville Hotels
- Motels in Stewartville
- Farmstay in Lanesboro
- Apartments in Lanesboro
- B&B in Lanesboro
- Cabins in Lanesboro
- Cottages in Lanesboro
- Golf Resorts & in Lanesboro
- Spa Resorts & in Lanesboro
- Lanesboro Hotels
- Inns in Lanesboro
- Motels in Lanesboro
- Vacation Homes in Lanesboro
- Villas in Lanesboro
- B&B in Whalan
- Cabins in Whalan
- Guest Houses in Whalan
- Whalan Hotels
- Inns in Whalan
- Lodges in Whalan
- Villas in Whalan
- B&B in Preston
- Cabins in Preston
- Guest Houses in Preston
- Kid Friendly Hotels in Preston
- Hotels with Pools in Preston
- Preston Hotels
- Motels in Preston
- Le Roy Hotels
- Hotels near Regional Sports Center
- Hotels near Mayo Clinic Hospital - Saint Marys Campus
- Peterson Hotels
- Motels in Grand Meadow
- B&B in Harmony
- Cabins in Harmony
- Extended Stay Hotels in Harmony
- Harmony Hotels
- 4 Star Hotels in Spring Valley
- Farmstay in Spring Valley
- Apartments in Spring Valley
- Cabins in Spring Valley
- Condos in Spring Valley
- Extended Stay Hotels in Spring Valley
- Spring Valley Hotels
- Vacation Homes in Spring Valley
- Hotels near Rochester Intl.
- Hotels near Soldiers Field Golf Course
- Canton Hotels
- Hotels near Plummer House
- Hotels near Deer Creek Speedway
- Hotels near Root River
- Eyota Hotels
- B&B in Chatfield
- Cabins in Chatfield
- Extended Stay Hotels in Chatfield
- Chatfield Hotels
- Motels in Chatfield
- Vacation Homes in Chatfield
- Hotels near Lanesboro Arts Center
- Hotels near Commonweal Theatre Company
- Hotels near Four Daughters Vineyard & Winery
- Flights to Harmony
- Flights from Rochester Intl.
- American Airlines Dallas (DFW) to Rochester (RST) flights
- Delta Detroit (DTW) to Rochester (RST) flights
- Delta Minneapolis (MSP) to Rochester (RST) flights
- Flights from Denver (DEN) to Rochester (RST)
- Flights from Des Moines (DSM) to Rochester (RST)
- Flights from Grand Rapids (GRR) to Rochester (RST)
- Flights from Kansas City (MCI) to Rochester (RST)
- Flights from Orlando (MCO) to Rochester (RST)
- Flights from Minneapolis (MSP) to Rochester (RST)
- Flights from Omaha (OMA) to Rochester (RST)
- Flights from Chicago (ORD) to Rochester (RST)
- Flights from Portland (PDX) to Rochester (RST)
- Flights from Phoenix (PHX) to Rochester (RST)
- Flights from Rapid City (RAP) to Rochester (RST)
- Flights from St. Louis (STL) to Rochester (RST)
- Flights to Chatfield






