Book Hotels in Wykoff, MN
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Top Wykoff hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Fully refundable
$126 nightly
The price is $145 total per night from Jun 20 to Jun 21
$145 total
Jun 20 - Jun 21
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Weird experience at the front desk, where the manager guy seemed super annoyed. He reprimanded a customer checking in for parking in the garage before check-in (how are we supposed to know not to do this), and another person because he couldn’t find their booking, complaining loudly that “everyone ..."
Reviewed on May 31, 2026

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $172 total per night from Jun 5 to Jun 6
$172 total
Jun 5 - Jun 6
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"Great location, a few minutes walk to the civic center. Plenty of good food options around the area. The staff is friendly and helpful, rooms and commons are clean, loved the breakfast menu."
Reviewed on Jun 1, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$112 nightly
The price is $129 total per night from Jun 20 to Jun 21
$129 total
Jun 20 - Jun 21
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"Great option in Rochester"
Reviewed on May 31, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from Jun 5 to Jun 6
$131 total
Jun 5 - Jun 6
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
"nice quiet clean hotel, enjoyed the pool with basketball and jacuzzi. quiet but close to downtown. can walk or drive to downtown. restaurant is nice & convenient. they privide shuttle to & from destination during available times."
Reviewed on May 31, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
$153 nightly
The price is $176 total per night from Jun 15 to Jun 16
$176 total
Jun 15 - Jun 16
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Rooms are kind of small, but fair price and most important connected to Mayo. I use them any time I have an appointment there."
Reviewed on Jun 1, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
1517 16th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Jun 7 to Jun 8
$108 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Bring the family and enjoy the children's pool, waterslide, and arcade/game room. Enjoy the ...
"Great place"
Reviewed on May 29, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
$155 nightly
The price is $178 total per night from Jun 14 to Jun 15
$178 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
"A bit of an old, confusing building, but the staff did their best to make it comfortable."
Reviewed on Jun 1, 2026

Med City Inn & Suites - Mayo Clinic Area
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $97 total per night from Jun 3 to Jun 4
$97 total
Jun 3 - Jun 4
Total with taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
"Pretty good place for the price. I felt safe and the people were really nice."
Reviewed on May 30, 2026

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
4353 Canal Pl SE Rochester MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Jun 7 to Jun 8
$84 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel's 3 indoor pools and gym are among the featured amenities. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Everything was great 👍 wonderful breakfast"
Reviewed on May 31, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Wykoff hotel reviews by fellow wanderers

Kahler Grand Hotel
4 out of 5
Posted 4 hours ago
Travelocity Verified Review
"Rooms are kind of small, but fair price and most important connected to Mayo. I use them any time I have an appointment there."
A verified traveler stayed at Kahler Grand Hotel
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