Book Hotels in Wykoff, MN

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Wykoff hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
Fully refundable
$126 nightly
The price is $145 total per night from Jun 20 to Jun 21
$145 total
Jun 20 - Jun 21
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Very pleased with this property."

Reviewed on Jun 6, 2026

Opens in a new windowEVEN Hotel Rochester - Mayo Clinic Area by IHG
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$169 nightly
The price is $195 total per night from Jun 12 to Jun 13
$195 total
Jun 12 - Jun 13
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"Great room and good breakfast!"

Reviewed on Jun 7, 2026

Opens in a new windowHyatt House Rochester/Mayo Clinic Area
Hampton Inn Rochester-South

Hampton Inn Rochester-South

2.5 out of 5
1755 S Broadway Rochester MN
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $99 total per night from Jul 5 to Jul 6
$99 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Enjoy the hot tub and free perks like buffet breakfast and free self parking. You'll appreciate the free ...
"Good stay"

Reviewed on Jun 7, 2026

Opens in a new windowHampton Inn Rochester-South
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
Fully refundable
$112 nightly
The price is $129 total per night from Jun 20 to Jun 21
$129 total
Jun 20 - Jun 21
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"Very clean & comfortable and the staff were super helpful in shipping my lost items!"

Reviewed on Jun 7, 2026

Opens in a new windowHotel Indigo Rochester – Mayo Clinic Area by IHG
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from Jun 12 to Jun 13
$131 total
Jun 12 - Jun 13
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
"My daughter and I stayed one night as she had an appointment at Mayo, and Cornerstone offers shuttle service. I had also eaten at the adjoining restaurant before, and Twig's is just the best! Especially if you need to eat gluten-free, which is the case for me."

Reviewed on Jun 7, 2026

Opens in a new windowCenterstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$146 nightly
The price is $168 total per night from Jul 8 to Jul 9
$168 total
Jul 8 - Jul 9
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"1"

Reviewed on Jun 3, 2026

Opens in a new windowKahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $178 total per night from Jun 14 to Jun 15
$178 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
"Staff is always very helpful and nice. Breakfast is good. Pool was warm!"

Reviewed on Jun 5, 2026

Opens in a new windowKahler Inn and Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $97 total per night from Jun 9 to Jun 10
$97 total
Jun 9 - Jun 10
Total with taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
"Horrible stay. My wife got bed bugs"

Reviewed on Jun 6, 2026

Opens in a new windowMed City Inn & Suites - Mayo Clinic Area
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

3 out of 5
4353 Canal Pl SE Rochester MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Jun 14 to Jun 15
$84 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel's 3 indoor pools and gym are among the featured amenities. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Love this Hotel. Always clean, staff is friendly and helpful. Perfect area with MANY eats close by. I do dog Agility and there are large open areas to walk and potty the dogs. ALWAYS stay here when I am in town."

Reviewed on Jun 6, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Don't see what you're looking for?
See all available properties in Wykoff
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Wykoff?
From well-thought-out amenities to extra space, kid-friendly hotels come with features that can help turn a regular family vacation into a fantastic one. These Wykoff properties make vacationing with little ones easy: The entire crew will love staying at Welcoming mid-century modern history-friendly home in bluff county.. A playground and a king bed are among the things that help make this hotel a sought-after option. Otherwise, spend your Wykoff break at Friendly-Farm Retreat. Make the most of a playground, a king bed and more here.
Where can I find cheap hotels in Wykoff?
At Travelocity you'll find really nice hotels in Wykoff at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Wykoff rather than in Wykoff. We may find you even better rates, too.
How do I find the best Wykoff hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Wykoff then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Wykoff?
The cheapest hotel in Wykoff is $84. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Wykoff?
There are 324 hotels in Wykoff on Travelocity.
What are the best hotels in Wykoff?
Wykoff has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Wykoff for you!
When is the best time to visit Wykoff?
If you want the joy of a fun-filled trip in peak season, visit Wykoff during May, July and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as November, December and January.
When is the cheapest time to stay in Wykoff?
Based on historic data is usually the cheapest month to visit Wykoff. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Wykoff?
There are multiple hotels in Wykoff that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Wykoff. We have plenty of kid-friendly hotels in Wykoff to choose from on Travelocity!
Why book a hotel in Wykoff through Travelocity?
Because we have the top hotels in Wykoff! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Wykoff on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Wykoff hotel reviews by fellow wanderers

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

5 out of 5
Posted 2 hours ago
Travelocity Verified Review
"My daughter and I stayed one night as she had an appointment at Mayo, and Cornerstone offers shuttle service. I had also eaten at the adjoining restaurant before, and Twig's is just the best! Especially if you need to eat gluten-free, which is the case for me."
A verified traveler stayed at Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Explore More Ways to Travel with Travelocity