Book Hotels in Wykoff, MN
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Top Wykoff hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Fully refundable
$126 nightly
The price is $145 total per night from Mar 6 to Mar 7
$145 total
Mar 6 - Mar 7
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Clean, great staff & close to St Mary’s hospital
Reviewed on Feb 28, 2026

Aspen Suites
1211 2nd Street Rochester MN
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $149 total per night from Mar 7 to Mar 8
$149 total
Mar 7 - Mar 8
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Very clean room, very nice staff, wonderful breakfasts, convient to Mayo Clinic, wonderful shuttle, beautiful setting in dining room, great computer, all of it was really super great
Reviewed on Feb 28, 2026

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $160 total per night from Mar 14 to Mar 15
$160 total
Mar 14 - Mar 15
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Staff, location, clean & soup in the evenings.
Reviewed on Feb 25, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$95 nightly
The price is $109 total per night from Mar 14 to Mar 15
$109 total
Mar 14 - Mar 15
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
The room was large and modern! Very nice staff
Reviewed on Feb 25, 2026

Holiday Inn Express Rochester South - Mayo Area by IHG
4141 Maine Avenue SE Rochester MN
Fully refundable
$93 nightly
The price is $107 total per night from Mar 9 to Mar 10
$107 total
Mar 9 - Mar 10
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Room was very clean, staff was friendly and polite, this hotel has a pool and workout room, beds are comfortable, also have a hot breakfast!
Reviewed on Feb 27, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Mar 4 to Mar 5
$146 total
Mar 4 - Mar 5
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
The queen size was more like a double bed but the hotel accommodated us by an upgrade to a king. Place was clean and friendly staff but the rooms are somewhat dated. Overall, for the convenience of being connected to Mayo, and the friendly accommodating staff, I would give it a 8.4/10.
Reviewed on Feb 28, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $88 total per night from Mar 20 to Mar 21
$88 total
Mar 20 - Mar 21
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
Staff was courteous and the room was clean.
Reviewed on Feb 28, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from Mar 2 to Mar 3
$152 total
Mar 2 - Mar 3
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
Wife came up for a surgery at mayo when she was released from hospital she needed a handicap accessible bathroom which i didnt think about in my original booking the manager made phone calls to other people who booked them rooms and was able to get us in one! They went above and beyond!
Reviewed on Feb 28, 2026

The Berkman
217 14th Ave SW Rochester MN
Fully refundableReserve now, pay when you stay
$150 nightly
The price is $173 total per night from Mar 28 to Mar 29
$173 total
Mar 28 - Mar 29
Total with taxes and fees
This aparthotel features a gym and a seasonal outdoor pool. Enjoy the a rooftop terrace and perks like free WiFi. Self parking, a 24-hour business center, and ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Wykoff hotel reviews by fellow wanderers

Kahler Inn and Suites - Mayo Clinic Area
5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Comfortable, clean room. Perfect location and accessibility."
A verified traveler stayed at Kahler Inn and Suites - Mayo Clinic Area
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