Book Hotels in Wykoff, MN
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Top Wykoff hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Fully refundable
$130 nightly
The price is $149 total per night from Jun 28 to Jun 29
$149 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Amazing place to stay , highly recommend"
Reviewed on Jun 21, 2026

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$169 nightly
The price is $195 total per night from Jun 27 to Jun 28
$195 total
Jun 27 - Jun 28
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"Staff were uniformly friendly and helpful. That made all the difference for us since we were commuting to/from Mayo Clinic. The free breakfast was decent, but lacked variety, wearing thin during our 1 week stay. Trash was not emptied nearly often enough from the small bins near the elevators. Also ..."
Reviewed on Jun 19, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$120 nightly
The price is $138 total per night from Jun 30 to Jul 1
$138 total
Jun 30 - Jul 1
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"The staff were nice and helpful. The room and hotel were clean. Housecleaning is advertised as being included, however it is by request only. Requests for what you want done in your room (i.e. trash can emptied, bed made, bathroom cleaned) must be checked and turned in before 8 am for the room to ..."
Reviewed on Jun 22, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $118 total per night from Jul 9 to Jul 10
$118 total
Jul 9 - Jul 10
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
"Absolutely amazing hotel to stay at if you have celiac or need to be gluten free. It was a dream! Rooms are a little dated but overall great place and location to Mayo!"
Reviewed on Jun 23, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $151 total per night from Jun 30 to Jul 1
$151 total
Jun 30 - Jul 1
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"The Kahler is always an excellent choice…particularly if you are visiting the Mayo Clinic."
Reviewed on Jun 22, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
1517 16th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $91 total per night from Jun 28 to Jun 29
$91 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Bring the family and enjoy the children's pool, waterslide, and arcade/game room. Enjoy the ...
"Clean room and facilities. Although we didn't have kids, the pool area looked fun for the family. Great location to Mayo Clinic. We will be staying there again on our next trip."
Reviewed on Jun 21, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $88 total per night from Jul 12 to Jul 13
$88 total
Jul 12 - Jul 13
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
"Easy check in and out. Quiet room"
Reviewed on Jun 20, 2026

Med City Inn & Suites - Mayo Clinic Area
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $87 total per night from Jul 9 to Jul 10
$87 total
Jul 9 - Jul 10
Total with taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
"Once hot breakfast was added it was a great improvement. The dining area is keep clean & isn’t crowded. Staff at front desk varied from nice to snarky. My Doctor cancelled my surgery for medical reasons & ordered me back in 2 weeks. No refunds or credits at given or allowed. Think carefully about ..."
Reviewed on Jun 22, 2026

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
4353 Canal Pl SE Rochester MN
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $87 total per night from Jul 5 to Jul 6
$87 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel's 3 indoor pools and gym are among the featured amenities. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"The mattress on the bed was well used. A dip in the middle. 😏 The shower/tub in the bathroom was slippery when using the shower. My husband almost fell. There was no closet. However, it was quiet and the staff was very gracious. We will stay there again."
Reviewed on Jun 21, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Recent Wykoff hotel reviews by fellow wanderers

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
5 out of 5
Posted 12 hours ago
Travelocity Verified Review
"Absolutely amazing hotel to stay at if you have celiac or need to be gluten free. It was a dream! Rooms are a little dated but overall great place and location to Mayo!"
A verified traveler stayed at Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
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