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Top Tenderloin Spa Resorts & Hotels

Hotel Nikko San Francisco

222 Mason St San Francisco CA

Free Cancellation

Reserve now, pay when you stay

$191 nightly

$225 total

Jan 4 - Jan 5, 2026

Total with taxes and fees

A nightclub, 2 restaurants, and an indoor pool are all featured at this luxury hotel. Enjoy the gym and perks like free WiFi. You'll appreciate the a rooftop ...

The Marker Union Square San Francisco

501 Geary St San Francisco CA

Free Cancellation

Reserve now, pay when you stay

$140 nightly

$164 total

Dec 16 - Dec 17

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. If you want to take your pet along, this pet-friendly property offers everything you'll need ...

The Clift Royal Sonesta San Francisco

495 Geary St San Francisco CA

Free Cancellation

Reserve now, pay when you stay

$182 nightly

$214 total

Dec 25 - Dec 26

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...

Handlery Union Square Hotel

351 Geary St San Francisco CA

Free Cancellation

Reserve now, pay when you stay

$132 nightly

$155 total

Dec 23 - Dec 24

Total with taxes and fees

This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. ...

Hotel Spero, Vignette Collection by IHG

405 Taylor St San Francisco CA

Free Cancellation

$157 nightly

$185 total

Dec 15 - Dec 16

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, 24-hour business center, ...

Parc 55 San Francisco - A Hilton Hotel

55 Cyril Magnin St San Francisco CA

Free Cancellation

Reserve now, pay when you stay

$164 nightly

$193 total

Dec 21 - Dec 22

Total with taxes and fees

This Art Deco hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public ...

Hilton San Francisco Union Square

333 O'Farrell St. San Francisco CA

Free Cancellation

Reserve now, pay when you stay

$165 nightly

$195 total

Dec 21 - Dec 22

Total with taxes and fees

The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center and ...

COVA Hotel

655 Ellis Street San Francisco CA

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This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Tenderloin hotels essential information

Accommodation	4,689 hotels
Lowest Price	$155
Highest Price	$225
Popular hotels	Hotel Nikko San Francisco, Hilton San Francisco Union Square, The Marker Union Square San Francisco, Parc 55 San Francisco - A Hilton Hotel, The Clift Royal Sonesta San Francisco, Handlery Union Square Hotel, Hotel Spero, Vignette Collection by IHG, COVA Hotel