Book Hotels in Picayune, MS
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Top Picayune hotels

The Southern Hotel
Great charming hotel with lots of character. Awesome bar downstairs in the lobby as well. We sat and enjoyed $5 old fashions for hours
Reviewed on Feb 5, 2026

Holiday Inn Express Picayune-Stennis Space Center by IHG
Good location. Friendly staff Clean room.
Reviewed on Feb 3, 2026

Comfort Inn & Suites
Room was very clean. Bed was extremely comfortable. The only thing that was not beyond expectation was that we had trouble changing temperature in the room. Heat was set on 71 and couldn't be changed. AC was set on 69 and couldn't be changed.
Reviewed on Jan 31, 2026

Heritage Inn Picayune
Clean room and the nice staff
Reviewed on Jan 4, 2026

Microtel Inn & Suites by Wyndham Pearl River/Slidell
Clean rooms. Quiet area. Everyone so friendly. Kelly at check-in is always so friendly. Krystal from housekeeping is very nice asked if we need anything . My favorite is Regina she does the breakfast she is the sweetest she helps and brings food to the ones who are handicap or old. She will actually ...
Reviewed on Feb 11, 2026

Hollywood Casino Gulf Coast
Clean rooms friendly service
Reviewed on Feb 4, 2026

Quality Inn Slidell I-10
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Reviewed on Feb 1, 2026

Ramada by Wyndham Diamondhead I-10/Gulfport
Very nice staff and very clean and comfortable
Reviewed on Feb 1, 2026

Days Inn by Wyndham Picayune
Clean room
Reviewed on Jan 30, 2026
Cheap Picayune hotels

Super 8 by Wyndham Picayune
Picayune Hotel & Travel Guide\n
If the world is your oyster, find a hidden pearl in the small city of Picayune, Mississippi. Located in Pearl River County, its name means “small coin” in Spanish and holds much more value for explorers than its nearness to New Orleans. Watch birds take flight above the mysterious swamp as you inhale the sweet scent of magnolias and it’ll be hard to believe you're just minutes from the neon lights of the Big Easy.
Visiting Picayune
When your plane lands at the Louis Armstrong International Airport, about 60 miles from Picayune, you’ll see verdant greenery all around and smell the salty tang of the bayou's brackish waters as you head to your destination. A range of Picayune hotel deals free up the budget of curious adventurers like yourself for more exploration in this new city. Step back in time on East Canal Street by roaming through musty antique shops full of hidden treasures. Feel the oiled wood of a colonial antique birdcage, or pick up an alligator head dating back more than a century. Sate your inner foodie along West Canal Street, where you can linger over a Southern-style brunch, washing down hearty biscuits and sausage gravy with a grapefruit mimosa.
Reserving a Picayune car rental lets you partake in the traditions of Bourbon Street revelry within minutes. Spend a night at one of the famous (or infamous) hotels in New Orleans, stepping right outside your front door and following the sound of live music. Guitar riffs in the air might lead you to a dive bar with cheap beer or an upscale lounge serving the famed NOLA hurricane cocktails. If you don't want to stay in the Big Easy, head back to one of the comfortable, affordable Picayune hotels.
Find what pearls await in the South by booking hotels in Picayune through Travelocity. With our Price Guarantee, we'll match any lower prices or refund the difference, getting you the best possible deals.
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Recent Picayune hotel reviews by fellow wanderers

Microtel Inn & Suites by Wyndham Pearl River/Slidell
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