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Top hotels in Mayo Clinic

Hotel Valley Ho

Hotel Valley Ho

4.5 out of 5
6850 E Main St Scottsdale AZ
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $154 total per night from Jul 26 to Jul 27
$154 total
Jul 26 - Jul 27
Total with taxes and fees
A full-service spa, 2 outdoor pools, and a 24-hour gym are all featured at this luxury resort. Traveling on business? Take advantage of the business center, ...
"A beautiful property! Staff very friendly!"

Reviewed on Jul 1, 2026

Opens in a new windowHotel Valley Ho
Talking Stick Resort

Talking Stick Resort

4 out of 5
9800 E. Talking Stick Way Scottsdale AZ
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $181 total per night from Jul 13 to Jul 14
$181 total
Jul 13 - Jul 14
Total with taxes and fees
This resort features a golf course, a casino, and a full-service spa. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"Nothing better than the rooms here at talking stick casino. Love this place."

Reviewed on Jul 2, 2026

Opens in a new windowTalking Stick Resort
Arizona Biltmore, LXR Hotels & Resorts

Arizona Biltmore, LXR Hotels & Resorts

5 out of 5
2400 E Missouri Avenue Phoenix AZ
Fully refundableReserve now, pay when you stay
$233 nightly
The price is $264 total per night from Jul 26 to Jul 27
$264 total
Jul 26 - Jul 27
Total with taxes and fees
This smoke-free resort features a golf course, a full-service spa, and 7 restaurants. Family-friendly amenities include a waterslide and kid-friendly dining, ...
"Property is well maintained. Staff is knowledgeable and friendly. Lovely pool and clean rooms. Spa has many amenities"

Reviewed on Jun 30, 2026

Opens in a new windowArizona Biltmore, LXR Hotels & Resorts
FOUNDRE Phoenix

FOUNDRE Phoenix

4 out of 5
1100 N Central Avenue Phoenix AZ
Fully refundableReserve now, pay when you stay
$113 nightly
The price is $128 total per night from Jul 3 to Jul 4
$128 total
Jul 3 - Jul 4
Total with taxes and fees
This hotel features 2 bars/lounges, a poolside bar, and a restaurant. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
"Fluid dimension queer. I was so impressed with the Canta for. I will definitely be back"

Reviewed on Jul 1, 2026

Opens in a new windowFOUNDRE Phoenix
Marriott Phoenix Resort Tempe at The Buttes

Marriott Phoenix Resort Tempe at The Buttes

4 out of 5
2000 W Westcourt Way Tempe AZ
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $181 total per night from Jul 19 to Jul 20
$181 total
Jul 19 - Jul 20
Total with taxes and fees
2 outdoor pools, 4 outdoor tennis courts, and a gym are all featured at this smoke-free resort. Traveling on business? Take advantage of the business center ...
"Beautiful place!"

Reviewed on Jun 30, 2026

Opens in a new windowMarriott Phoenix Resort Tempe at The Buttes
Arizona Grand Resort & Spa

Arizona Grand Resort & Spa

4 out of 5
8000 S. Arizona Grand Parkway Phoenix AZ
Fully refundableReserve now, pay when you stay
$184 nightly
The price is $208 total per night from Jul 9 to Jul 10
$208 total
Jul 9 - Jul 10
Total with taxes and fees
This smoke-free resort features a golf course, free water park access, and a full-service spa. Bring the family and enjoy the lazy river, children's pool, and ...
"Beautiful ,peaceful place to relax."

Reviewed on Jul 2, 2026

Opens in a new windowArizona Grand Resort & Spa
SureStay By Best Western Phoenix Airport

SureStay By Best Western Phoenix Airport

2.5 out of 5
3037 E Van Buren St Phoenix AZ
Fully refundableReserve now, pay when you stay
$69 nightly
The price is $78 total per night from Jul 3 to Jul 4
$78 total
Jul 3 - Jul 4
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free self parking, and a free airport shuttle. Business travelers can take ...
"Specifically chose this hotel for the airport shuttle upon checking in. I asked the guy at the front desk about having a shuttle for the following morning. I stated that we would need it between seven and 715. Got there at 7:03 and was informed that the shuttle had just left at seven, which I begged ..."

Reviewed on Jun 30, 2026

Opens in a new windowSureStay By Best Western Phoenix Airport
Hilton Phoenix Resort at the Peak

Hilton Phoenix Resort at the Peak

4 out of 5
7677 N 16th St Phoenix AZ
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $153 total per night from Jul 21 to Jul 22
$153 total
Jul 21 - Jul 22
Total with taxes and fees
This smoke-free resort features free water park access, a full-service spa, and 2 restaurants. There's fun for all ages with a lazy river and mini golf, and ...
"Pool closed earlier than we expected. It's still hot at 7pm. Part of the hotel appears to be going through renovation.. but it wasnt loud."

Reviewed on Jul 1, 2026

Opens in a new windowHilton Phoenix Resort at the Peak
Hilton Phoenix Tapatio Cliffs Resort

Hilton Phoenix Tapatio Cliffs Resort

4 out of 5
11111 N 7th St Phoenix AZ
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $145 total per night from Jul 6 to Jul 7
$145 total
Jul 6 - Jul 7
Total with taxes and fees
This Mediterranean resort features a golf course, free water park access, and a full-service spa. Bring the family and enjoy the waterslide and kid-friendly ...
Opens in a new windowHilton Phoenix Tapatio Cliffs Resort
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Mayo Clinic Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Mayo Clinic area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Mayo Clinic to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Mayo Clinic are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Mayo Clinic hotel reviews by fellow wanderers

Talking Stick Resort

Talking Stick Resort

5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Nothing better than the rooms here at talking stick casino. Love this place."
A verified traveler stayed at Talking Stick Resort
Talking Stick Resort

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