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Top hotels in Mayo Clinic

Hotel Valley Ho

Hotel Valley Ho

4.5 out of 5
6850 E Main St Scottsdale AZ
Fully refundableReserve now, pay when you stay
$299 nightly
The price is $341 total per night from Jan 25 to Jan 26
$341 total
Jan 25 - Jan 26
Total with taxes and fees
A full-service spa, 2 outdoor pools, and a 24-hour gym are all featured at this luxury resort. Traveling on business? Take advantage of the business center, ...
The Terrace Suite was adorable. The bed was very comfortable. The room was very clean. The staff was extremely friendly and accommodating. The location was excellent.

Reviewed on Jan 13, 2026

Opens in a new windowHotel Valley Ho
Talking Stick Resort

Talking Stick Resort

4 out of 5
9800 E. Talking Stick Way Scottsdale AZ
$364 nightly
The price is $415 total per night from Feb 15 to Feb 16
$415 total
Feb 15 - Feb 16
Total with taxes and fees
This resort features a golf course, a casino, and a full-service spa. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Everything was great

Reviewed on Jan 14, 2026

Opens in a new windowTalking Stick Resort
Arizona Biltmore, LXR Hotels & Resorts

Arizona Biltmore, LXR Hotels & Resorts

5 out of 5
2400 E Missouri Avenue Phoenix AZ
Fully refundableReserve now, pay when you stay
$625 nightly
The price is $707 total per night from Jan 30 to Jan 31
$707 total
Jan 30 - Jan 31
Total with taxes and fees
This smoke-free resort features a golf course, a full-service spa, and 7 restaurants. Family-friendly amenities include a waterslide and kid-friendly dining, ...
Spotless room. Beautiful grounds.

Reviewed on Jan 13, 2026

Opens in a new windowArizona Biltmore, LXR Hotels & Resorts
Hyatt Regency Phoenix

Hyatt Regency Phoenix

4 out of 5
122 N 2nd St Phoenix AZ
$224 nightly
The price is $253 total per night from Jan 23 to Jan 24
$253 total
Jan 23 - Jan 24
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the business center, free WiFi in public ...
An exceptional hotel, the rooms were beautiful, and the staff was very accommodating. Would stay again

Reviewed on Jan 11, 2026

Opens in a new windowHyatt Regency Phoenix
Scottsdale Plaza Resort

Scottsdale Plaza Resort

4 out of 5
7200 N Scottsdale Rd Paradise Valley AZ
Fully refundableReserve now, pay when you stay
$268 nightly
The price is $304 total per night from Jan 22 to Jan 23
$304 total
Jan 22 - Jan 23
Total with taxes and fees
This luxury resort features a full-service spa, 3 outdoor pools, and a restaurant. Traveling on business? Take advantage of the 2 conference rooms, express check-out, ...
Nice resort with clean rooms! Food at restaurant was amazing! Will return for a visit!

Reviewed on Jan 7, 2026

Opens in a new windowScottsdale Plaza Resort
Papago Scottsdale by Reside, Trademark Collection by Wyndham

Papago Scottsdale by Reside, Trademark Collection by Wyndham

3 out of 5
7017 East McDowell Road Scottsdale AZ
Fully refundableReserve now, pay when you stay
$108 nightly
The price is $123 total per night from Jan 25 to Jan 26
$123 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Self parking, a 24-hour business center, ...
The hotel is beautiful, clean and close to attractions. I gave one star less because housekeeping did not clean the room for 2 of the 4 days I was there even after reminding multiple times. Front staff was very pleasant. Another drawback is that there is no breakfast available at the hotel. On site ...

Reviewed on Jan 9, 2026

Opens in a new windowPapago Scottsdale by Reside, Trademark Collection by Wyndham
Hilton Phoenix Tapatio Cliffs Resort

Hilton Phoenix Tapatio Cliffs Resort

4 out of 5
11111 N 7th St Phoenix AZ
Fully refundableReserve now, pay when you stay
$202 nightly
The price is $228 total per night from Jan 25 to Jan 26
$228 total
Jan 25 - Jan 26
Total with taxes and fees
This Mediterranean resort features a golf course, free water park access, and a full-service spa. Families will appreciate the waterslide and onsite laundry ...
Good

Reviewed on Jan 15, 2026

Opens in a new windowHilton Phoenix Tapatio Cliffs Resort
Crowne Plaza Phoenix Airport - PHX by IHG

Crowne Plaza Phoenix Airport - PHX by IHG

3.5 out of 5
4300 E Washington St Phoenix AZ
Fully refundable
$134 nightly
The price is $152 total per night from Jan 25 to Jan 26
$152 total
Jan 25 - Jan 26
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Great location to airport

Reviewed on Jan 16, 2026

Opens in a new windowCrowne Plaza Phoenix Airport - PHX by IHG
Studio 6 Tempe, AZ

Studio 6 Tempe, AZ

2 out of 5
4909 S Wendler Dr. Tempe AZ
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $67 total per night from Jan 20 to Jan 21
$67 total
Jan 20 - Jan 21
Total with taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this motel. WiFi in public areas is free. Barbecue grills are provided for your ...
Staff is courteous, amenities can use improement. Clean property

Reviewed on Jan 16, 2026

Opens in a new windowStudio 6 Tempe, AZ
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Mayo Clinic Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Mayo Clinic area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Mayo Clinic to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Mayo Clinic are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Mayo Clinic hotel reviews by fellow wanderers

Hilton Garden Inn Phoenix Airport North

Hilton Garden Inn Phoenix Airport North

5 out of 5
Posted 5 hours ago
Travelocity Verified Review
"The hotel staff was very friendly and accommodating while we were there! We really enjoyed our stay "
A verified traveler stayed at Hilton Garden Inn Phoenix Airport North
Hilton Garden Inn Phoenix Airport North

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