Defiance Vacation Packages 2025/2026 from $317

Defiance flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

The Knight Center at Washington University

$317

per person

Jan 1 - Jan 3

found 1 day ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Self parking and a coffee shop are also offered on site.

The West End

Central West End

$392

per person

Dec 17 - Dec 20

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

A 24-hour gym, self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Express check-out is provided and the front desk is staffed around-the-clock.

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Grand Center

$319

per person

Jan 1 - Jan 3

found 1 day ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. There's a rooftop terrace on site, and a 24-hour front desk and a snack bar/deli are also provided.

Ameristar Casino Resort and Spa

$533

per person

Dec 17 - Dec 20

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside bar.

Riverside Inn Hannibal

$463

per person

Dec 12 - Dec 14

found 1 day ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

This guesthouse doesn't skimp on freebies - guests receive free WiFi and free self parking. A restaurant and express check-out are also provided.

Top Defiance hotels deals

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive, Maryland Heights, MO

Free Cancellation

Reserve now, pay when you stay

$89 nightly

$104 total

Nov 23 - Nov 24

Total with taxes and fees

A casino, 7 restaurants, and a 24-hour gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, express check-out, and free airport shuttle. Relax with a drink at one of the 3 bars/lounges and enjoy perks like free self parking.

Free airport shuttle

Parking included

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

1088 South Highway Drive, Fenton, MO

Free Cancellation

Reserve now, pay when you stay

$85 nightly

$98 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Pool

Hot Tub

Hilton St. Louis Frontenac

1335 S Lindbergh Blvd, Frontenac, MO

Free Cancellation

Reserve now, pay when you stay

$139 nightly

$161 total

Nov 16 - Nov 17

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport shuttle. Enjoy the seasonal outdoor pool and perks like free self parking and a free area shuttle.

Pool

Free airport shuttle

La Quinta Inn & Suites by Wyndham St. Louis Westport

11805 Lackland Rd, Maryland Heights, MO

Free Cancellation

Reserve now, pay when you stay

$89 nightly

$103 total

Dec 7 - Dec 8

Total with taxes and fees

This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport shuttle. Guests will appreciate freebies like self-serve breakfast and free self parking.

Pool

Breakfast included

The Wildwood Hotel

2801 Fountain Pl, Wildwood, MO

Free Cancellation

Reserve now, pay when you stay

$88 nightly

$103 total

Nov 12 - Nov 13

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Pool

Hot Tub

Hampton Inn St. Charles St. Peters

3720 W Clay St, St. Charles, MO

Free Cancellation

Reserve now, pay when you stay

$95 nightly

$109 total

Nov 16 - Nov 17

Total with taxes and fees

This hotel features an indoor pool and a 24-hour gym. Enjoy the hot tub and free perks like buffet breakfast and free self parking. A 24-hour business center, free WiFi in public areas, and a picnic area are also on offer.

Pool

Hot Tub

Don't see what you're looking for?

See all available properties in Defiance

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Busch Stadium

4.5/5(1,469 reviews)

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's great live music or attend a baseball game.

St. Louis Union Station

4/5(615 reviews)

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game.

Gateway Arch

4.5/5(2,511 reviews)

Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.

Frequently asked questions

How much are vacation packages to Defiance?

Treat yourself to a one-of-a-kind experience in Defiance with a vacation package starting from just $317. Organizing your hotels, tours and flights with Travelocity is a piece of cake. What's more, our vacation deals will leave you with extra cash for loads of fun times.

Where can I get the best vacation package deals for Defiance?

It's difficult to beat Travelocity when it comes to piecing together your Defiance package deal. There are as many as 400 partner airlines and 1,000,000 properties around the world to choose from. Secure your trip now and get ready to cross another amazing place off your travel bucket list.

Why should I purchase my Defiance vacation package with Travelocity?

From our 24/7 customer care to our range of fantastic destinations, we're committed to fulfilling your travel desires. All you'll have to do is click and book — our Price Match Guarantee will make sure you score the best price.

Can I save on my Defiance car rental if I bundle it with my hotel or flight?

With a Defiance vacation package, you can bundle your hotel, car and flight bookings and save some serious money. If you'd love to discover the best of this wonderful part of the world, why not head to Busch Stadium? This popular attraction is 30 mi from Defiance. With your own rental car, you'll be there before you know it.

Which airport is best for Defiance?

Lambert-St. Louis Intl. Airport (STL) is the top airport for those flying to Defiance. Once you touch down, you'll find yourself 25 mi east of the downtown area.

What is there to do in Defiance?

There is a certain magic in the air as you stroll the streets of Defiance. Chandler Hill Vineyards and Historic Daniel Boone Home and Heritage Center are just two famous sights that make this city so popular, so put them at the top of your must-see list.

Where should I stay when visiting Defiance?

The BACKYARD OASIS! Cozy and charming 60s Brick ranch with relaxing gazebo over pond is recommended by many travelers. Book soon to avoid missing out.