Defiance Vacation Packages 2026 from $355

Defiance flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Hilton Garden Inn Chesterfield

$355

per person

Feb 1 - Feb 3

found 1 day ago

Roundtrip flight included

Minneapolis (MSP) to St. Louis (STL)

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the 24-hour gym and perks like free self parking.

Hotel Saint Louis, Autograph Collection

Downtown St. Louis

$441

per person

Feb 1 - Feb 3

found 1 day ago

Roundtrip flight included

Minneapolis (MSP) to St. Louis (STL)

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. There's a bar/lounge on site, and laundry facilities and concierge services are also provided.

St. Louis Union Station Hotel, Curio Collection by Hilton

Downtown West

$520

per person

Feb 1 - Feb 3

found 1 day ago

Roundtrip flight included

Minneapolis (MSP) to St. Louis (STL)

This historic hotel's 7 restaurants, 3 bars/lounges, and 24-hour gym are some of the featured amenities. Enjoy the seasonal outdoor pool and perks like free WiFi. Valet parking, a business center, and a coffee shop are also offered.

Four Seasons Hotel St Louis

Downtown St. Louis

$683

per person

Feb 1 - Feb 3

found 1 day ago

Roundtrip flight included

Minneapolis (MSP) to St. Louis (STL)

A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Families will appreciate kid-friendly dining and in-room childcare. Traveling on business? Take advantage of the 24-hour business center, express check-out, and valet parking.

Moonrise Hotel

Delmar Loop

$432

per person

Feb 1 - Feb 3

found 1 day ago

Roundtrip flight included

Minneapolis (MSP) to St. Louis (STL)

The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. Enjoy a meal from the a restaurant and perks like free self parking.

Top Defiance hotels deals

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

1088 South Highway Drive Fenton MO

Free Cancellation

Reserve now, pay when you stay

$85 nightly

$98 total

Dec 28 - Dec 29

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Pool

Hot Tub

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

Free Cancellation

Reserve now, pay when you stay

$183 nightly

$214 total

Dec 29 - Dec 30

Total with taxes and fees

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside bar.

Pool

Hot Tub

The Wildwood Hotel

2801 Fountain Pl Wildwood MO

Free Cancellation

Reserve now, pay when you stay

$92 nightly

$108 total

Jan 8 - Jan 9, 2026

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Pool

Hot Tub

La Quinta Inn & Suites by Wyndham St. Louis Westport

11805 Lackland Rd Maryland Heights MO

Free Cancellation

Reserve now, pay when you stay

$82 nightly

$95 total

Dec 28 - Dec 29

Total with taxes and fees

This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport shuttle. Guests will appreciate freebies like self-serve breakfast and free self parking.

Pool

Breakfast included

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

13639 Riverport Dr Maryland Heights MO

Free Cancellation

Reserve now, pay when you stay

$66 nightly

$77 total

Jan 4 - Jan 5, 2026

Total with taxes and fees

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.

Pool

Breakfast included

Best Western Plus The Charles Hotel

1425 South 5th Street St. Charles MO

Free Cancellation

Reserve now, pay when you stay

$88 nightly

$102 total

Dec 29 - Dec 30

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.

Pool

Breakfast included

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

St. Louis Union Station

4/5(615 reviews)

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's fascinating museums or attend a baseball game.

Busch Stadium

4.5/5(1,469 reviews)

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's great live music or attend a baseball game.

Gateway Arch

4.5/5(2,511 reviews)

Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.

Frequently asked questions

How much are vacation packages to Defiance?

Treat yourself to a one-of-a-kind experience in Defiance with a vacation package starting from just $355. Organizing your hotels, tours and flights with Travelocity is a piece of cake. What's more, our vacation deals will leave you with extra cash for loads of fun times.

Where can I get the best vacation package deals for Defiance?

It's difficult to beat Travelocity when it comes to piecing together your Defiance package deal. There are as many as 400 partner airlines and 1,000,000 properties around the world to choose from. Secure your trip now and get ready to cross another amazing place off your travel bucket list.

Why should I purchase my Defiance vacation package with Travelocity?

From our 24/7 customer care to our range of fantastic destinations, we're committed to fulfilling your travel desires. All you'll have to do is click and book — our Price Match Guarantee will make sure you score the best price.

Can I save on my Defiance car rental if I bundle it with my hotel or flight?

With a Defiance vacation package, you can bundle your hotel, car and flight bookings and save some serious money. If you'd love to discover the best of this wonderful part of the world, why not head to Busch Stadium? This popular attraction is 30 mi from Defiance. With your own rental car, you'll be there before you know it.

Which airport is best for Defiance?

Lambert-St. Louis Intl. Airport (STL) is the top airport for those flying to Defiance. Once you touch down, you'll find yourself 25 mi east of the downtown area.

What is there to do in Defiance?

There is a certain magic in the air as you stroll the streets of Defiance. Chandler Hill Vineyards and Historic Daniel Boone Home and Heritage Center are just two famous sights that make this city so popular, so put them at the top of your must-see list.

Where should I stay when visiting Defiance?

The BACKYARD OASIS! Cozy and charming 60s Brick ranch with relaxing gazebo over pond is recommended by many travelers. Book soon to avoid missing out.