Explore top 2025 5 Star Hotels in Destin

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Top Destin 5 Star hotels

The Henderson Beach Resort & Spa

The Henderson Beach Resort & Spa

5 out of 5
200 Henderson Resort Way, Destin, FL
Fully refundableReserve now, pay when you stay
$398 nightly
The price is $450 total per night from Sep 28 to Sep 29
$450 total
Sep 28 - Sep 29
Total with taxes and fees
A full-service spa, 4 restaurants, and 2 outdoor pools are all featured at this smoke-free resort. Relax with sun loungers and beach umbrellas, and cool off ...
9.2/10 Wonderful! (1,014 reviews)
"We had an incredible view from our hotel room and the hotel had endless things to do. Absolutely beautiful place to stay and only wish we could have stayed for longer."

Reviewed on Sep 21, 2025

Opens in a new windowThe Henderson Beach Resort & Spa
The Blue Pearl

The Blue Pearl

5 out of 5
9700 Grand Sandestin Blvd, Miramar Beach, FL
A full-service spa, 3 outdoor pools, and 3 hot tubs are all featured at this luxury condo resort. Enjoy the a rooftop terrace and conveniences like a picnic ...
Opens in a new windowThe Blue Pearl
Capitano 7 Bedroom Holiday Home by Five Star Properties

Capitano 7 Bedroom Holiday Home by Five Star Properties

5 out of 5
4700 Ocean Blvd, Destin, FL
Free WiFi in public areas is available at this vacation home. Take advantage of the free self parking.
Opens in a new windowCapitano 7 Bedroom Holiday Home by Five Star Properties
Stranded on a Sandbar 8 Bedroom Holiday Home by Five Star Properties

Stranded on a Sandbar 8 Bedroom Holiday Home by Five Star Properties

5 out of 5
76 Miami Street, Miramar Beach, Miramar Beach, FL
Free WiFi in public areas is available at this vacation home. Take advantage of the free self parking.
Opens in a new windowStranded on a Sandbar 8 Bedroom Holiday Home by Five Star Properties
Palazzo del Mar 11 Bedroom Holiday Home by Five Star Properties

Palazzo del Mar 11 Bedroom Holiday Home by Five Star Properties

5 out of 5
2990 Scenic Gulf Dr, Destin, FL
Free WiFi in public areas is available at this vacation home. Take advantage of the free self parking.
Opens in a new windowPalazzo del Mar 11 Bedroom Holiday Home by Five Star Properties
Casa de Palms 5 Bedroom Holiday Home by Five Star Properties

Casa de Palms 5 Bedroom Holiday Home by Five Star Properties

5 out of 5
55 Balamore Rd, Miramar Beach, Miramar Beach, FL
Free WiFi in public areas is available at this vacation home. Take advantage of the free self parking.
Opens in a new windowCasa de Palms 5 Bedroom Holiday Home by Five Star Properties
Vista del Mare 4 Bedroom Holiday Home by Five Star Properties

Vista del Mare 4 Bedroom Holiday Home by Five Star Properties

5 out of 5
4753 Ocean Blvd, Destin, FL
Free WiFi in public areas is available at this vacation home. Take advantage of the free self parking.
Opens in a new windowVista del Mare 4 Bedroom Holiday Home by Five Star Properties
Palazzo del Mar by Five Star Properties

Palazzo del Mar by Five Star Properties

5 out of 5
2990 Scenic Highway 98, Destin, FL
An outdoor pool, free self parking, and barbecue grills are featured at this vacation home. WiFi in public areas is free. A terrace is also provided.
Opens in a new windowPalazzo del Mar by Five Star Properties
Modern Paradise by Five Star Properties

Modern Paradise by Five Star Properties

5 out of 5
4642 Paradise Isles, Destin, FL
This vacation home features an outdoor pool and a gym. Guests will appreciate free perks like free self parking and WiFi in public areas. Barbecue grills are ...
Opens in a new windowModern Paradise by Five Star Properties
Casa Esmeralda by Five Star Properties

Casa Esmeralda by Five Star Properties

5 out of 5
4624 Sunset Pointe, Destin, FL
This vacation home features an outdoor pool and a gym. Guests will appreciate free perks like free self parking and WiFi in public areas. Barbecue grills are ...
Opens in a new windowCasa Esmeralda by Five Star Properties
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Destin Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Destin to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Destin 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Destin before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Destin hotel reviews by fellow wanderers