Explore top 2025 5 Star Hotels in Buffalo

Name: Curtiss Hotel, an Ascend Collection Hotel
Price range: $307 total
Rating: 9.2

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Top Buffalo 5 Star hotels

Curtiss Hotel, an Ascend Collection Hotel

210 Franklin St, Buffalo, NY

Fully refundable

$263 nightly

$307 total

Dec 9 - Dec 10

Total with taxes and fees

This smoke-free hotel features a full-service spa, hot springs, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free ...

9.2/10 Wonderful! (1,003 reviews)

Room was spotless. Very accommodating staff and the shower was over the top.

Reviewed on Nov 8, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Buffalo Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Buffalo to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Buffalo 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Buffalo before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.