Explore top 2025 4 Star Hotels in Mississippi Gulf Coast

Name: Handsboro Pointe Condo & Suites
Price range: $300 total
Rating: 9.8

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Top Mississippi Gulf Coast 4 Star hotels

Hard Rock Hotel & Casino Biloxi

777 Beach Blvd., Biloxi, MS

Fully refundableReserve now, pay when you stay

$82 nightly

$92 total

Oct 29 - Oct 30

Total with taxes and fees

This hotel features a casino, a nightclub, and 5 restaurants. Enjoy the 4 outdoor pools and perks like free self parking and free WiFi. Make the most of the ...

8.2/10 Very Good! (3,376 reviews)

"Clean room"

Reviewed on Oct 20, 2025

IP Casino Resort Spa - Biloxi

850 Bayview Ave, Biloxi, MS

Fully refundableReserve now, pay when you stay

$88 nightly

$99 total

Nov 9 - Nov 10

Total with taxes and fees

This resort features a casino, a full-service spa, and a nightclub. Enjoy a meal in one of the 7 restaurants and free perks like valet parking and WiFi in public ...

8.4/10 Very Good! (5,071 reviews)

"Excellent Hotel and casino"

Reviewed on Oct 17, 2025

Palace Casino Resort

158 Howard Ave, Biloxi, MS

Fully refundableReserve now, pay when you stay

$79 nightly

$88 total

Nov 2 - Nov 3

Total with taxes and fees

This smoke-free hotel features a casino, a full-service spa, and 5 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

9.2/10 Wonderful! (2,928 reviews)

"Room clean and very spacious. Bed was super comfy! Love the no smoking! Great experience"

Reviewed on Oct 18, 2025

Beau Rivage

875 Beach Blvd, Biloxi, MS

$150 nightly

$168 total

Oct 23 - Oct 24

Total with taxes and fees

This resort features a casino, a full-service spa, and 10 restaurants. Relax with a drink at one of the 7 bars/lounges and enjoy perks like free valet parking. ...

9.2/10 Wonderful! (1,434 reviews)

"There was debris on floor, dust in room, room was never cleaned during stay."

Reviewed on Oct 12, 2025

Golden Nugget Biloxi

151 Beach Blvd, Biloxi, MS

Fully refundableReserve now, pay when you stay

$78 nightly

$85 total

Oct 28 - Oct 29

Total with taxes and fees

This resort features a casino, a full-service spa, and a nightclub. Business travelers can take advantage of the express check-out. You'll find 4 restaurants ...

8/10 Very Good! (2,675 reviews)

"The room was just as advertised on the site. Very spacious, very comfortable. Incredible viewpoint outside. The hot tub was an enjoyable experience. My only two complaints are that there was no please do not disturb sign for us to hang (very very minor complaint), and it was difficult to figure out ..."

Reviewed on Oct 17, 2025

Harrah’s Gulf Coast – A Caesars Rewards Destination

280 Beach Boulevard, Biloxi, MS

$80 nightly

$89 total

Nov 2 - Nov 3

Total with taxes and fees

This resort features a casino, a full-service spa, and 8 restaurants. Traveling on business? Take advantage of the express check-out and onsite conference space. ...

7.6/10 Good! (1,336 reviews)

"Front desk staff was very nice."

Reviewed on Oct 14, 2025

Scarlet Pearl Casino Resort

9380 Central Ave, D'Iberville, MS

Fully refundableReserve now, pay when you stay

$119 nightly

$133 total

Oct 23 - Oct 24

Total with taxes and fees

A casino, 4 restaurants, and an outdoor pool are all featured at this traditional hotel. Traveling on business? Take advantage of the free WiFi in public areas ...

9.2/10 Wonderful! (1,527 reviews)

"Everything was great"

Reviewed on Oct 16, 2025

Doubletree by Hilton Hattiesburg, MS

10 Gateway Dr, Hattiesburg, MS

Fully refundableReserve now, pay when you stay

$89 nightly

$98 total

Nov 2 - Nov 3

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

8/10 Very Good! (1,003 reviews)

"The room was clean and comfortable. The staff were friendly and professional. We appreciate having breakfast as a choice instead of being included and having the option of a king bed.."

Reviewed on Oct 4, 2025

DoubleTree by Hilton Hotel Biloxi

940 Beach Boulevard, Biloxi, MS

Fully refundableReserve now, pay when you stay

$105 nightly

$117 total

Nov 9 - Nov 10

Total with taxes and fees

This hotel features an outdoor pool, a gym, and a restaurant. Relax with a drink at the bar/lounge and enjoy perks like free self parking and free WiFi. A business ...

8/10 Very Good! (1,006 reviews)

"Bar tender was very nice. Bar was stocked."

Reviewed on Oct 16, 2025

Handsboro Pointe Condo & Suites

1302 Magnolia St, Gulfport, MS

$268 nightly

$300 total

Oct 26 - Oct 27

Total with taxes and fees

A seasonal outdoor pool is featured at this apartment, along with a virtual front desk. Take advantage of the free self parking.

9.8/10 Exceptional! (70 reviews)

Great Place for a Longer Stay in Gulfport

"I’ve stayed here twice and highly recommend it. The units are quiet and comfortable. It is very well managed."

Reviewed on Oct 17, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Mississippi Gulf Coast

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Mississippi Gulf Coast 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Mississippi Gulf Coast will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Mississippi Gulf Coast, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.