Explore 49 Luxury Hotels in Mississippi Gulf Coast

Name: Magnolia Inn Townhouse Hattiesburg MS I-59
Price range: $66 total

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Best Luxury Hotels in Mississippi Gulf Coast

Beau Rivage

875 Beach Blvd Biloxi MS

$150 nightly

$168 total

Oct 29 - Oct 30

Total with taxes and fees

This resort features a casino, a full-service spa, and 10 restaurants. Relax with a drink at one of the 7 bars/lounges and enjoy perks like free valet parking. ...

9.4/10 Exceptional! (1,445 reviews)

"Nice"

Reviewed on Oct 15, 2026

White House Hotel

1230 Beach Blvd Biloxi MS

Fully refundableReserve now, pay when you stay

$119 nightly

$134 total

Oct 18 - Oct 19

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public ...

9/10 Wonderful! (1,071 reviews)

"The White House is such a charming historic property, and the staff is so courteous and helpful. The bar and Cora's restaurant are also excellent."

Reviewed on Oct 13, 2026

IP Casino Resort Spa - Biloxi

850 Bayview Ave Biloxi MS

Fully refundableReserve now, pay when you stay

$100 nightly

$112 total

Nov 1 - Nov 2

Total with taxes and fees

This resort features a casino, a full-service spa, and a nightclub. Enjoy a meal in one of the 7 restaurants and free perks like valet parking and WiFi in public ...

8.8/10 Excellent! (5,012 reviews)

"Everything was smooth and a nice place to stay."

Reviewed on Oct 14, 2026

Microtel Inn & Suites by Wyndham Hattiesburg

105 Westover Dr Hattiesburg MS

Fully refundableReserve now, pay when you stay

$63 nightly

$69 total

Nov 1 - Nov 2

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...

8.6/10 Excellent! (1,086 reviews)

"Generally very good. The lobby television was placed/oriented such that it could not be readily watched from the breakfast area."

Reviewed on Oct 14, 2026

Harrah's Gulf Coast Hotel & Casino - A Caesars Rewards Destination

280 Beach Boulevard Biloxi MS

$80 nightly

$89 total

Nov 15 - Nov 16

Total with taxes and fees

This resort features a casino, a full-service spa, and 8 restaurants. Traveling on business? Take advantage of the express check-out and onsite conference space. ...

7.8/10 Good! (1,644 reviews)

"I love the view, pool, and hot tub. The bathroom wasn't so clean. There was hair on the toilet and in the tub. Ewwww."

Reviewed on Oct 15, 2026

Margaritaville Resort Biloxi

195 Beach Blvd Biloxi MS

Fully refundableReserve now, pay when you stay

$113 nightly

$124 total

Oct 25 - Oct 26

Total with taxes and fees

A water park, 3 restaurants, and a lazy river are all featured at this hotel. Bring the family and enjoy the waterslide, arcade/game room, and kid-friendly dining. ...

Golden Nugget Biloxi

151 Beach Blvd Biloxi MS

Fully refundableReserve now, pay when you stay

$71 nightly

$77 total

Oct 27 - Oct 28

Total with taxes and fees

This resort features a casino, a full-service spa, and a nightclub. Business travelers can take advantage of the express check-out. You'll find 4 restaurants ...

Magnolia Inn Townhouse Hattiesburg MS I-59

6655 Highway 49 N. Hattiesburg MS

Fully refundableReserve now, pay when you stay

$60 nightly

$66 total

Oct 18 - Oct 19

Total with taxes and fees

The hotel doesn't skimp on freebies - guests receive free continental breakfast and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Mississippi Gulf Coast

Beachside Biloxi Club Condo: Balcony w/ Ocean View

Biloxi MS

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10/10 Exceptional! (1 review)

Mississippi Gulf Coast Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Mississippi Gulf Coast luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Mississippi Gulf Coast to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Mississippi Gulf Coast will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Mississippi Gulf Coast, and plan your next opulent escape.

Mississippi Gulf Coast hotels essential information

Accommodation	3,069 hotels
Lowest Price	$66
Highest Price	$231
Popular hotels	Beau Rivage, Margaritaville Resort Biloxi, White House Hotel, IP Casino Resort Spa - Biloxi, Golden Nugget Biloxi, Magnolia Inn Townhouse Hattiesburg MS I-59, Harrah's Gulf Coast Hotel & Casino - A Caesars Rewards Destination, Microtel Inn & Suites by Wyndham Hattiesburg