Explore 49 Luxury Hotels in Mississippi Gulf Coast

Name: Magnolia Inn Townhouse Hattiesburg MS I-59
Price range: $64 total

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Best Luxury Hotels in Mississippi Gulf Coast

White House Hotel

1230 Beach Blvd Biloxi MS

Fully refundableReserve now, pay when you stay

$119 nightly

$134 total

Nov 1 - Nov 2

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public ...

9/10 Wonderful! (1,079 reviews)

"Rooms were very well done. Excellent view."

Reviewed on Oct 23, 2026

Margaritaville Resort Biloxi

195 Beach Blvd Biloxi MS

Fully refundableReserve now, pay when you stay

$113 nightly

$124 total

Oct 25 - Oct 26

Total with taxes and fees

A water park, 3 restaurants, and a lazy river are all featured at this hotel. Bring the family and enjoy the waterslide, arcade/game room, and kid-friendly dining. ...

8.6/10 Excellent! (6,458 reviews)

"Everything was really nice!!"

Reviewed on Oct 23, 2026

Microtel Inn & Suites by Wyndham Hattiesburg

105 Westover Dr Hattiesburg MS

Fully refundableReserve now, pay when you stay

$62 nightly

$68 total

Nov 1 - Nov 2

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...

8.6/10 Excellent! (1,088 reviews)

"This hotel was such a great value! There are fountain drinks and coffee 24 hours a day. The hotel was decorated for fall, smelled great, and Keisha at the front desk could not have been any sweeter or more helpful. The room was so clean and nice! I cannot believe I only paid $80 to stay here. The ..."

Reviewed on Oct 23, 2026

Harrah's Gulf Coast Hotel & Casino - A Caesars Rewards Destination

280 Beach Boulevard Biloxi MS

$88 nightly

$99 total

Nov 22 - Nov 23

Total with taxes and fees

This resort features a casino, a full-service spa, and 8 restaurants. Traveling on business? Take advantage of the express check-out and onsite conference space. ...

7.8/10 Good! (1,639 reviews)

"We did like the Pool. But, the rest of the hotel was run down and dirty. We stayed three nights, the 18th of October through the 21st. The room were freezing cold. The halls looked as if they had not been vacuumed and or dusted in a long while. When we entered our room, it was just as cold if not ..."

Reviewed on Oct 22, 2026

Beau Rivage

875 Beach Blvd Biloxi MS

$150 nightly

$168 total

Oct 29 - Oct 30

Total with taxes and fees

This resort features a casino, a full-service spa, and 10 restaurants. Relax with a drink at one of the 7 bars/lounges and enjoy perks like free valet parking. ...

IP Casino Resort Spa - Biloxi

850 Bayview Ave Biloxi MS

Fully refundableReserve now, pay when you stay

$91 nightly

$102 total

Nov 23 - Nov 24

Total with taxes and fees

This resort features a casino, a full-service spa, and a nightclub. Enjoy a meal in one of the 7 restaurants and free perks like valet parking and WiFi in public ...

Golden Nugget Biloxi

151 Beach Blvd Biloxi MS

Fully refundableReserve now, pay when you stay

$75 nightly

$82 total

Nov 22 - Nov 23

Total with taxes and fees

This resort features a casino, a full-service spa, and a nightclub. Business travelers can take advantage of the express check-out. You'll find 4 restaurants ...

Magnolia Inn Townhouse Hattiesburg MS I-59

6655 Highway 49 N. Hattiesburg MS

Fully refundableReserve now, pay when you stay

$58 nightly

$64 total

Oct 25 - Oct 26

Total with taxes and fees

The hotel doesn't skimp on freebies - guests receive free continental breakfast and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Mississippi Gulf Coast

Beachside Biloxi Club Condo: Balcony w/ Ocean View

Biloxi MS

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10/10 Exceptional! (1 review)

Mississippi Gulf Coast Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Mississippi Gulf Coast luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Mississippi Gulf Coast to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Mississippi Gulf Coast will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Mississippi Gulf Coast, and plan your next opulent escape.

Mississippi Gulf Coast hotels essential information

Accommodation	3,051 hotels
Lowest Price	$64
Highest Price	$226
Popular hotels	Beau Rivage, Margaritaville Resort Biloxi, White House Hotel, IP Casino Resort Spa - Biloxi, Golden Nugget Biloxi, Magnolia Inn Townhouse Hattiesburg MS I-59, Harrah's Gulf Coast Hotel & Casino - A Caesars Rewards Destination, Microtel Inn & Suites by Wyndham Hattiesburg