Explore top 2026 4 Star Hotels in Jeffersonville

Name: The Grady
Price range: $233 total
Rating: 9.4

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Top Jeffersonville 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$150 nightly

$177 total

Oct 25 - Oct 26

Total with taxes and fees

A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

9/10 Wonderful! (4,294 reviews)

"Great rooms, a number of great restaurants and bars, great staff. I will come back next time I am in Louisville."

Reviewed on Sep 24, 2026

Omni Louisville Hotel

400 S. 2nd Street Louisville KY

Fully refundableReserve now, pay when you stay

$279 nightly

$329 total

Oct 2 - Oct 3

Total with taxes and fees

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.4/10 Exceptional! (2,152 reviews)

"The best part of the experience was the presence of multiple eateries and shopping areas within the hotel campus."

Reviewed on Sep 24, 2026

Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

4520 Poplar Level Rd Louisville KY

Fully refundableReserve now, pay when you stay

$89 nightly

$105 total

Oct 25 - Oct 26

Total with taxes and fees

This smoke-free hotel features 3 restaurants and 3 bars/lounges. Guests will appreciate free perks like free self parking and WiFi in public areas. A coffee ...

9.4/10 Exceptional! (2,528 reviews)

"Very nice and clean place."

Reviewed on Sep 23, 2026

The Brown Hotel

335 W Broadway Louisville KY

Fully refundableReserve now, pay when you stay

$161 nightly

$189 total

Sep 28 - Sep 29

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...

Hyatt Regency Louisville

320 West Jefferson Street Louisville KY

Fully refundableReserve now, pay when you stay

$178 nightly

$209 total

Oct 15 - Oct 16

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

8.8/10 Excellent! (1,002 reviews)

"Clean rooms, good room service, amazing on site restaraunt and bar. In door pool is kinda small but clean"

Reviewed on Sep 23, 2026

Embassy Suites Louisville Downtown

501 South Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$163 nightly

$192 total

Oct 11 - Oct 12

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...

Hotel Genevieve part of JdV by Hyatt

730 E Market St Louisville KY

Fully refundableReserve now, pay when you stay

$152 nightly

$179 total

Oct 4 - Oct 5

Total with taxes and fees

This hotel features a restaurant and 2 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and a snack bar/deli are also offered.

9.2/10 Wonderful! (1,104 reviews)

"Amazing hotel - fun decor, loved the room layout, so comfortable with wonderful staff. In a great area of town. Did not want to leave!"

Reviewed on Sep 24, 2026

Louisville Marriott Downtown

280 West Jefferson Street Louisville KY

Fully refundableReserve now, pay when you stay

$214 nightly

$252 total

Oct 4 - Oct 5

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9/10 Wonderful! (1,001 reviews)

"The vending machines were completely empty. On every floor. Rooms were clean and beds were comfy. Could use new or different pillows though. They get super flat. Making them get hot fast and obviously uncomfortable. The staff was great and was able to accommodate us checking in pretty late."

Reviewed on Sep 22, 2026

21c Museum Hotel Louisville

700 W Main Street Louisville KY

Fully refundableReserve now, pay when you stay

$182 nightly

$214 total

Oct 25 - Oct 26

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.4/10 Exceptional! (1,001 reviews)

"Terrible experience. I will never rebook with this hotel chain."

Reviewed on Sep 23, 2026

The Grady

601 W Main St Louisville KY

Fully refundableReserve now, pay when you stay

$198 nightly

$233 total

Oct 11 - Oct 12

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.

9.4/10 Exceptional! (1,010 reviews)

"The bed was incredibly uncomfortable and lumpy. The pillows screwed up my neck. However, Kevin and Farrah at the front desk were incredibly helpful. We ate at the hotel restaurant and the food was good. Overall, the people working there were great! The beds and pillows were not to my liking but that ..."

Reviewed on Sep 23, 2026

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4 Star Hotels Jeffersonville

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Jeffersonville 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Jeffersonville will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Jeffersonville, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Jeffersonville hotel reviews by fellow wanderers

Galt House Hotel Trademark Collection by Wyndham

5 out of 5

Posted 3 hours ago

Travelocity Verified Review

"Great rooms, a number of great restaurants and bars, great staff. I will come back next time I am in Louisville."

A verified traveler stayed at Galt House Hotel Trademark Collection by Wyndham

Derby Hotel & Suites

5 out of 5

Posted 4 hours ago

Travelocity Verified Review

"Check in was easy and attendant was very friendly and nice to chat with, It’s a good budget hotel if all you need is a place to sleep and get ready for the day. Room was decent and the air conditioner worked very nice, it was nice to have a fridge to store some leftovers."

A verified traveler stayed at Derby Hotel & Suites