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May 29 - May 31
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Jun 5 - Jun 7

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Top hotels in Serra Mesa

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$276 nightly
The price is $320 total per night from Jun 5 to Jun 6
$320 total
Jun 5 - Jun 6
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"Stayed in a newly renovated room and it was great!"

Reviewed on May 29, 2026

Opens in a new windowManchester Grand Hyatt San Diego
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$212 nightly
The price is $246 total per night from Jun 7 to Jun 8
$246 total
Jun 7 - Jun 8
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
"Good place"

Reviewed on May 29, 2026

Opens in a new windowHard Rock Hotel San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$248 nightly
The price is $285 total per night from May 31 to Jun 1
$285 total
May 31 - Jun 1
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
"Staff , property , amenities were all wonderful. The tidal restaurant was AMAZING!"

Reviewed on May 27, 2026

Opens in a new windowParadise Point Resort & Spa
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundable
$143 nightly
The price is $166 total per night from Jun 7 to Jun 8
$166 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"There was only one elevator that was working but the staff made every effort to help the guests. Nice staff and clean hotel! I would definitely recommend this hotel to anyone visiting San Diego!"

Reviewed on May 29, 2026

Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$192 nightly
The price is $223 total per night from Jun 29 to Jun 30
$223 total
Jun 29 - Jun 30
Total with taxes and fees
A restaurant and a 24-hour gym are featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
"Very close to everything, unfortunately not as many facilities as would be expected for a hotel that costs so much. In fairness it is a nice historic building well located. The $75 per night deposit was a bit of a surprise and I don’t believe it is mentioned beforehand. I would stay there again however ..."

Reviewed on May 30, 2026

Opens in a new windowThe Sofia Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Jun 1 to Jun 2
$211 total
Jun 1 - Jun 2
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
"Only good thing is the hotel is near the Bay."

Reviewed on May 30, 2026

Opens in a new windowWyndham San Diego Bayside
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $102 total per night from Jun 1 to Jun 2
$102 total
Jun 1 - Jun 2
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
"Staff was very kind. Room was very clean, not too noisy either despite being close to the freeway. People book an economy Days Inn thinking they’re getting the Ritz Carlton and then leave reviews as such. It has more than everything expected for the price. We didn’t park a car but know that it is ..."

Reviewed on May 30, 2026

Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $94 total per night from May 31 to Jun 1
$94 total
May 31 - Jun 1
Total with taxes and fees
2 hot tubs, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
"Clean and comfortable. Great location."

Reviewed on May 30, 2026

Opens in a new windowBest Western Seven Seas
California Suites Hotel

California Suites Hotel

2 out of 5
5415 Clairemont Mesa Blvd San Diego CA
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $114 total per night from May 31 to Jun 1
$114 total
May 31 - Jun 1
Total with taxes and fees
This hotel features an outdoor pool and a hot tub. Traveling for business? Take advantage of the free WiFi in public areas, express check-out, and conference ...
"Unfortunately we didn’t get the chance to relax and enjoy the pool or hot tub as the outdoor space was the best part of the property. It was beautifully maintained and landscaped other than the fact that huge bundles of wires snaked over roofs and down the outside walls. Very thin walls you can hear ..."

Reviewed on May 28, 2026

Opens in a new windowCalifornia Suites Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Serra Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Serra Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Serra Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Serra Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Serra Mesa hotel reviews by fellow wanderers

The Sofia Hotel

The Sofia Hotel

5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Very close to everything, unfortunately not as many facilities as would be expected for a hotel that costs so much. In fairness it is a nice historic building well located. The $75 per night deposit was a bit of a surprise and I don’t believe it is mentioned beforehand. I would stay there again however not for more than a few days."
A verified traveler stayed at The Sofia Hotel
The Sofia Hotel

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