Book Hotels in Roxana, IL

Start date: Check-in selected.
To Date
End date: Check-out

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top Roxana hotels

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street St. Louis MO
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $168 total per night from Jan 4 to Jan 5
$168 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Yes everything was perfect for my daughter 7th birthday, staff was wonderful

Reviewed on Dec 26, 2025

Opens in a new windowDrury Plaza Hotel St. Louis at the Arch
Drury Inn & Suites St. Louis Union Station

Drury Inn & Suites St. Louis Union Station

3 out of 5
201 S 20th St St. Louis MO
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $142 total per night from Jan 4 to Jan 5
$142 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features an indoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
Merry Christmas

Reviewed on Dec 24, 2025

Opens in a new windowDrury Inn & Suites St. Louis Union Station
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
$148 nightly
The price is $173 total per night from Jan 25 to Jan 26
$173 total
Jan 25 - Jan 26, 2026
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
The entire hotel was fantastic. Beautifully decorated, so much to see. The art gallery was fantastic, the servers at the bar were friendly and phenomenal and just made for a great evening. The food was fantastic. Every inch of the building was well styled and the room was fantastic. Can’t wait to ...

Reviewed on Dec 22, 2025

Opens in a new window21C Museum Hotel St Louis
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $110 total per night from Jan 30 to Jan 31
$110 total
Jan 30 - Jan 31, 2026
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
The staff were wonderful. The room was clean and the shower had amazing water pressure !!

Reviewed on Dec 24, 2025

Opens in a new windowClayton Plaza Hotel & Extended Stay
Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

2.5 out of 5
333 Washington Ave St. Louis MO
$98 nightly
The price is $114 total per night from Jan 14 to Jan 15
$114 total
Jan 14 - Jan 15, 2026
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
There was a mistake

Reviewed on Dec 25, 2025

Opens in a new windowHampton Inn St. Louis-Downtown (At the Gateway Arch)
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
$97 nightly
The price is $115 total per night from Jan 25 to Jan 26
$115 total
Jan 25 - Jan 26, 2026
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
Great stay. Superb staff. Rooms were beautiful except bathroom very dated and the corners were not very clean

Reviewed on Dec 25, 2025

Opens in a new windowMagnolia Hotel St. Louis, a Tribute Portfolio Hotel
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
$129 nightly
The price is $152 total per night from Jan 1 to Jan 2
$152 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
Staff was supper nice and it all went so smooth.

Reviewed on Dec 26, 2025

Opens in a new windowHyatt Regency St. Louis at The Arch
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $143 total per night from Jan 16 to Jan 17
$143 total
Jan 16 - Jan 17, 2026
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
Clean rooms and friendly, accommodating staff.

Reviewed on Dec 24, 2025

Opens in a new windowRenaissance St. Louis Airport Hotel
Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown

3 out of 5
1221 Locus Street St. Louis MO
$78 nightly
The price is $91 total per night from Jan 14 to Jan 15
$91 total
Jan 14 - Jan 15, 2026
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast and free WiFi. Traveling on business? Take advantage of the 24-hour business center ...
I like

Reviewed on Dec 26, 2025

Opens in a new windowHome2 Suites by Hilton St. Louis Downtown
Don't see what you're looking for?
See all available properties in Roxana
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Roxana?
From well-designed amenities to extra room to move, kid-friendly hotels are equipped with features that can help transform a regular family vacation into an incredible one. These Roxana options make vacationing with your youngsters a snap: The whole team will love staying at Bel Air Motel. Front desk services and a picnic area are among the things that help make this place a winner. Best Western Premier Alton-St. Louis Area Hotel is also a great choice. After an exciting day of exploring Roxana, come back home to your comfy room and amenities like a swimming pool and pet-friendly facilities.
Where can I find cheap hotels in Roxana?
At Travelocity you'll find really nice hotels in Roxana at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Roxana rather than in Roxana. We may find you even better rates, too.
How do I find the best Roxana hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Roxana then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Roxana?
The cheapest hotel in Roxana is $91. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Roxana?
There are 1,349 hotels in Roxana on Travelocity.
What are the best hotels in Roxana?
Roxana has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Roxana for you!
When is the best time to visit Roxana?
If you want the joy of a fun-filled trip in peak season, visit Roxana during June, July and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as November, December and January.
When is the cheapest time to stay in Roxana?
Based on historic data is usually the cheapest month to visit Roxana. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Roxana?
There are multiple hotels in Roxana that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Roxana. We have plenty of kid-friendly hotels in Roxana to choose from on Travelocity!
Why book a hotel in Roxana through Travelocity?
Because we have the top hotels in Roxana! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Roxana on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Roxana hotel reviews by fellow wanderers

Live by Loews - St.Louis

Live by Loews - St.Louis

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Great view from room. Excellent service from staff."
A verified traveler stayed at Live by Loews - St.Louis
Live by Loews - St.Louis

Explore More Ways to Travel with Travelocity