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Top hotels in Mayo Clinic

Talking Stick Resort

Talking Stick Resort

4 out of 5
9800 E. Talking Stick Way Scottsdale AZ
Fully refundableReserve now, pay when you stay
$268 nightly
The price is $305 total per night from Nov 11 to Nov 12
$305 total
Nov 11 - Nov 12
Total with taxes and fees
This resort features a golf course, a casino, and a full-service spa. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"Rooms were clean and cozy. The staff were all very friendly"

Reviewed on Oct 11, 2026

Opens in a new windowTalking Stick Resort
Omni Scottsdale Resort & Spa at Montelucia

Omni Scottsdale Resort & Spa at Montelucia

4 out of 5
4949 E Lincoln Drive Paradise Valley AZ
$454 nightly
The price is $514 total per night from Oct 31 to Nov 1
$514 total
Oct 31 - Nov 1
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Traveling on business? Take advantage of the business center, ...
"The spa was fabulous. The staff was friendly, knowledgeable and very helpful. Overall very pleasant and will come back."

Reviewed on Oct 11, 2026

Opens in a new windowOmni Scottsdale Resort & Spa at Montelucia
Hilton Phoenix Tapatio Cliffs Resort

Hilton Phoenix Tapatio Cliffs Resort

4 out of 5
11111 N 7th St Phoenix AZ
Fully refundableReserve now, pay when you stay
$158 nightly
The price is $179 total per night from Nov 6 to Nov 7
$179 total
Nov 6 - Nov 7
Total with taxes and fees
This Mediterranean resort features a golf course, free water park access, and a full-service spa. Families will appreciate the waterslide and onsite laundry ...
"Na"

Reviewed on Oct 12, 2026

Opens in a new windowHilton Phoenix Tapatio Cliffs Resort
Marriott Phoenix Resort Tempe at The Buttes

Marriott Phoenix Resort Tempe at The Buttes

4 out of 5
2000 W Westcourt Way Tempe AZ
$221 nightly
The price is $252 total per night from Oct 30 to Oct 31
$252 total
Oct 30 - Oct 31
Total with taxes and fees
2 outdoor pools, 4 outdoor tennis courts, and a gym are all featured at this smoke-free resort. Traveling on business? Take advantage of the business center ...
"Loved the pool and rock views. Only problem I had was I booked on Expedia and got charged twice upon check in. Had to wait 24 hours before I got my money back… otherwise good stay and good location."

Reviewed on Oct 7, 2026

Opens in a new windowMarriott Phoenix Resort Tempe at The Buttes
Arizona Grand Resort & Spa

Arizona Grand Resort & Spa

4 out of 5
8000 S. Arizona Grand Parkway Phoenix AZ
Fully refundableReserve now, pay when you stay
$229 nightly
The price is $259 total per night from Oct 27 to Oct 28
$259 total
Oct 27 - Oct 28
Total with taxes and fees
This smoke-free resort features a golf course, free water park access, and a full-service spa. There's fun for all ages with a lazy river and a children's pool, ...
"5/5 stars and i would say i am somewhat a tough critic when it comes to hotels. Well maintained, comfortable and a ton of fun for the kids!"

Reviewed on Oct 11, 2026

Opens in a new windowArizona Grand Resort & Spa
City Express by Marriott Tempe

City Express by Marriott Tempe

3 out of 5
808 North Scottsdale Road Tempe AZ
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $97 total per night from Oct 18 to Oct 19
$97 total
Oct 18 - Oct 19
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
"Room and amenities were basic but clean and adequate. Great water pressure in the bathroom with variety of toiletries provided. Free breakfast was also pretty basic but adequate. Staffs were friendly and accommodating."

Reviewed on Oct 11, 2026

Opens in a new windowCity Express by Marriott Tempe
Hilton Phoenix Resort at the Peak

Hilton Phoenix Resort at the Peak

4 out of 5
7677 N 16th St Phoenix AZ
Fully refundableReserve now, pay when you stay
$255 nightly
The price is $289 total per night from Oct 29 to Oct 30
$289 total
Oct 29 - Oct 30
Total with taxes and fees
This smoke-free resort features free water park access, a full-service spa, and 2 restaurants. There's fun for all ages with a lazy river and mini golf, and ...
"C"

Reviewed on Oct 11, 2026

Opens in a new windowHilton Phoenix Resort at the Peak
FOUNDRE Phoenix

FOUNDRE Phoenix

4 out of 5
1100 N Central Avenue Phoenix AZ
Fully refundableReserve now, pay when you stay
$194 nightly
The price is $219 total per night from Oct 31 to Nov 1
$219 total
Oct 31 - Nov 1
Total with taxes and fees
This hotel features 2 bars/lounges, a poolside bar, and a restaurant. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
Opens in a new windowFOUNDRE Phoenix
Hotel Valley Ho

Hotel Valley Ho

4.5 out of 5
6850 E Main St Scottsdale AZ
Fully refundableReserve now, pay when you stay
$339 nightly
The price is $387 total per night from Nov 8 to Nov 9
$387 total
Nov 8 - Nov 9
Total with taxes and fees
A full-service spa, 2 outdoor pools, and a 24-hour gym are all featured at this luxury resort. Traveling on business? Take advantage of the business center, ...
Opens in a new windowHotel Valley Ho
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Mayo Clinic Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Mayo Clinic area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Mayo Clinic to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Mayo Clinic are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Mayo Clinic hotel reviews by fellow wanderers

Radisson Hotel Phoenix Airport

Radisson Hotel Phoenix Airport

4 out of 5
Posted 1 hour ago
Travelocity Verified Review
"."
A verified traveler stayed at Radisson Hotel Phoenix Airport
Radisson Hotel Phoenix Airport

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