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Top hotels in Central West End

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street St. Louis MO
$135 nightly
The price is $158 total per night from Mar 16 to Mar 17
$158 total
Mar 16 - Mar 17
Total with taxes and fees
2 hot tubs, an indoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in ...
Very nice staff and great atmosphere. Quietest hotel room i have ever stayed in

Reviewed on Mar 10, 2026

Opens in a new windowDrury Plaza Hotel St. Louis at the Arch
 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
212 N Kingshighway St. Louis MO
Fully refundableReserve now, pay when you stay
$184 nightly
The price is $217 total per night from Apr 5 to Apr 6
$217 total
Apr 5 - Apr 6
Total with taxes and fees
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
Dust in bathroom baseboards and on TV’s. 80 dollars for overnight parking with hotel or 40 with parking garage. Room service is convenient but a bit overpriced.

Reviewed on Mar 10, 2026

Opens in a new window The Royal Sonesta Chase Park Plaza St. Louis
AC Hotel St. Louis Central West End

AC Hotel St. Louis Central West End

4 out of 5
215 YORK AVENUE St. Louis MO
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $150 total per night from Apr 5 to Apr 6
$150 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...
The hotel is new; very clean, staff are super friendly and great location. This is our second time in 6 months - favorite hotel in central west end!

Reviewed on Mar 9, 2026

Opens in a new windowAC Hotel St. Louis Central West End
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $153 total per night from Apr 5 to Apr 6
$153 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Such a cool hotel I love the museum on the second floor so interesting and all the penguins food is great restaurants great everything just what a great stay very unique but very quiet very cozy love everything about it. Can’t wait to stay at the other ones.

Reviewed on Mar 11, 2026

Opens in a new window21C Museum Hotel St Louis
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $122 total per night from Mar 22 to Mar 23
$122 total
Mar 22 - Mar 23
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
This is an older property, but very clean, comfortable, spacious and convenient to downtown Clayton. Parking was convenient and free on the weekend. Breakfast was better than average, with chef-made omelets and waffles.

Reviewed on Mar 11, 2026

Opens in a new windowClayton Plaza Hotel & Extended Stay
The West End

The West End

2 out of 5
4215 Lindell Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$117 nightly
The price is $134 total per night from Mar 29 to Mar 30
$134 total
Mar 29 - Mar 30
Total with taxes and fees
A 24-hour gym, self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. A garden and express check-out are also ...
Very welcoming staff, hotel was clean

Reviewed on Mar 2, 2026

Opens in a new windowThe West End
Aloft St. Louis Cortex

Aloft St. Louis Cortex

3 out of 5
4245 Duncan Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $133 total per night from Mar 15 to Mar 16
$133 total
Mar 15 - Mar 16
Total with taxes and fees
This hotel features an indoor pool and a bar/lounge. WiFi in public areas is free. A 24-hour business center, a coffee shop, and a snack bar/deli are also on ...
Everything was great except parking.

Reviewed on Mar 11, 2026

Opens in a new windowAloft St. Louis Cortex
Hotel Indigo St Louis - Central West End by IHG

Hotel Indigo St Louis - Central West End by IHG

3.5 out of 5
4630 Lindell St. Louis MO
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $146 total per night from Mar 15 to Mar 16
$146 total
Mar 15 - Mar 16
Total with taxes and fees
This Art Deco hotel features 4 restaurants, a bar/lounge, and a 24-hour gym. Business travelers can take advantage of the free WiFi in public areas. Self parking, ...
nice

Reviewed on Mar 10, 2026

Opens in a new windowHotel Indigo St Louis - Central West End by IHG
DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

4 out of 5
4550 Forest Park Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $144 total per night from Apr 5 to Apr 6
$144 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...
When we checked into the hotel, our room was 77°. The front desk was called three times and an employee did come up to “reset” the thermometer. We were told no other rooms were available and the room was still 77° when we checked out the next day.

Reviewed on Mar 10, 2026

Opens in a new windowDoubleTree by Hilton St. Louis Forest Park
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Central West End Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Central West End area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Central West End to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Central West End are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Central West End hotel reviews by fellow wanderers

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