Explore 120 Luxury Hotels in Florida Keys

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Best Luxury Hotels in Florida Keys

H2O Suites - Adults Only

H2O Suites - Adults Only

1212 Simonton Street, Key West, FL
$339 nightly
The price is $381 total per night from Oct 26 to Oct 27
$381 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Business travelers can take advantage of the laundry service. There's a gym on site, and ...
9.8/10 Exceptional! (570 reviews)
Had a great stay! Property is very nice and conveniently located. Would definitely stay again.

Reviewed on Oct 21, 2025

Opens in a new windowH2O Suites - Adults Only
The Marker Key West Harbor Resort

The Marker Key West Harbor Resort

200 William Street, Key West, FL
Fully refundableReserve now, pay when you stay
$223 nightly
The price is $251 total per night from Oct 26 to Oct 27
$251 total
Oct 26 - Oct 27
Total with taxes and fees
This smoke-free hotel features 3 outdoor pools, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
9/10 Wonderful! (1,031 reviews)
Very comfortable hotel! Great location!

Reviewed on Oct 22, 2025

Opens in a new windowThe Marker Key West Harbor Resort
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82, Marker 82, Islamorada, FL
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $201 total per night from Oct 26 to Oct 27
$201 total
Oct 26 - Oct 27
Total with taxes and fees
This luxury resort features a private beach, a golf course, and a full-service spa. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. ...
9/10 Wonderful! (1,236 reviews)
Nice room with everything you need.

Reviewed on Oct 20, 2025

Opens in a new windowCheeca Lodge & Spa
Parmer's Resort

Parmer's Resort

565 Barry Avenue, Summerland Key, FL
Fully refundableReserve now, pay when you stay
$141 nightly
The price is $158 total per night from Oct 28 to Oct 29
$158 total
Oct 28 - Oct 29
Total with taxes and fees
The private beach and marina are among the highlights at this motel. Spend a day at the beach kayaking, or relax with sun loungers and beach umbrellas. Enjoy ...
9/10 Wonderful! (1,003 reviews)
Everything was sweet! Clean, breakfast good, property organized and boys at front desk very nice and polite! Excellent! Will definitely consider going back

Reviewed on Oct 14, 2025

Opens in a new windowParmer's Resort
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue, Key West, FL
Fully refundableReserve now, pay when you stay
$197 nightly
The price is $222 total per night from Nov 17 to Nov 18
$222 total
Nov 17 - Nov 18
Total with taxes and fees
A marina, 6 outdoor pools, and a 24-hour gym are all featured at this smoke-free hotel. Business travelers can take advantage of the free WiFi in public areas. ...
8.8/10 Excellent! (1,743 reviews)
Wasn't aware of "free breakfast." Where was it? Alex and Matia (spelling??) in the restaurant were wonderful.

Reviewed on Oct 20, 2025

Opens in a new windowOceans Edge Key West Resort, Hotel & Marina
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

1319 Duval Street, Key West, FL
Fully refundableReserve now, pay when you stay
$225 nightly
The price is $253 total per night from Oct 26 to Oct 27
$253 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel features a full-service spa, 3 outdoor pools, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling ...
8.6/10 Excellent! (2,805 reviews)
A great place to stay!

Reviewed on Oct 18, 2025

Opens in a new windowSouthernmost Beach Resort and Guesthouses
Kingsail Resort

Kingsail Resort

7050 Overseas Highway, Marathon, FL
$98 nightly
The price is $110 total per night from Nov 6 to Nov 7
$110 total
Nov 6 - Nov 7
Total with taxes and fees
A marina and an outdoor pool are featured at this smoke-free motel. Guests will appreciate free perks like free self parking and WiFi in public areas. A terrace, ...
8.4/10 Very Good! (1,025 reviews)
I’ve should be free

Reviewed on Oct 20, 2025

Opens in a new windowKingsail Resort
Casa Marina Key West, Curio Collection by Hilton

Casa Marina Key West, Curio Collection by Hilton

1500 Reynolds Street, Key West, FL
Fully refundableReserve now, pay when you stay
$287 nightly
The price is $323 total per night from Oct 26 to Oct 27
$323 total
Oct 26 - Oct 27
Total with taxes and fees
A private beach, a full-service spa, and 2 outdoor pools are all featured at this smoke-free resort. Relax with sun loungers and beach umbrellas, and cool off ...
8.2/10 Very Good! (400 reviews)
This hotel is beautiful. Great view from the room. Staff is amazing

Reviewed on Oct 19, 2025

Opens in a new windowCasa Marina Key West, Curio Collection by Hilton
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5 star hotels in Florida Keys

Florida Keys Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Florida Keys luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Florida Keys to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Florida Keys will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Florida Keys, and plan your next opulent escape.


Florida Keys hotels essential information

Accommodation
8,312 hotels
Lowest Price
$110
Highest Price
$617
Popular hotels
Oceans Edge Key West Resort, Hotel & Marina, The Marker Key West Harbor Resort, Cheeca Lodge & Spa, Casa Marina Key West, Curio Collection by Hilton, Kingsail Resort, Southernmost Beach Resort and Guesthouses, Parmer's Resort, H2O Suites - Adults Only

Popular Luxury Stays in Florida Keys

Recent Florida Keys Hotel Reviews By Fellow Wanderers