Explore 120 Luxury Hotels in Florida Keys

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Best Luxury Hotels in Florida Keys

H2O Suites - Adults Only

H2O Suites - Adults Only

1212 Simonton Street Key West FL
$939 nightly
The price is $1,056 total per night from Feb 8 to Feb 9
$1,056 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Business travelers can take advantage of the laundry service. There's a gym on site, and ...
9.8/10 Exceptional! (583 reviews)
Immaculate, beautifully decorated, warm and friendly staff. The welcome congratulation and champagne waiting for our arrival.

Reviewed on Dec 21, 2025

Opens in a new windowH2O Suites - Adults Only
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL
Fully refundableReserve now, pay when you stay
$340 nightly
The price is $383 total per night from Feb 4 to Feb 5
$383 total
Feb 4 - Feb 5
Total with taxes and fees
This luxury resort features a private beach, a golf course, and a full-service spa. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. ...
9.2/10 Wonderful! (1,301 reviews)
This palce is awesome. Clean rooms. 2 large pools with a view. Covered garage spot.

Reviewed on Jan 22, 2026

Opens in a new windowCheeca Lodge & Spa
The Marker Key West Harbor Resort

The Marker Key West Harbor Resort

200 William Street Key West FL
$635 nightly
The price is $714 total per night from Feb 2 to Feb 3
$714 total
Feb 2 - Feb 3
Total with taxes and fees
This smoke-free hotel features 3 outdoor pools, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
9/10 Wonderful! (1,009 reviews)
Excellent

Reviewed on Jan 25, 2026

Opens in a new windowThe Marker Key West Harbor Resort
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue Key West FL
Fully refundableReserve now, pay when you stay
$461 nightly
The price is $519 total per night from Feb 1 to Feb 2
$519 total
Feb 1 - Feb 2
Total with taxes and fees
A marina, 6 outdoor pools, and a 24-hour gym are all featured at this smoke-free hotel. Business travelers can take advantage of the free WiFi in public areas. ...
8.8/10 Excellent! (1,793 reviews)
Good... The carpet needs deep cleaned. Stayed here before and room was newer/cleaner.

Reviewed on Jan 26, 2026

Opens in a new windowOceans Edge Key West Resort, Hotel & Marina
Parmer's Resort

Parmer's Resort

565 Barry Avenue Summerland Key FL
Fully refundableReserve now, pay when you stay
$323 nightly
The price is $363 total per night from Feb 1 to Feb 2
$363 total
Feb 1 - Feb 2
Total with taxes and fees
The private beach and marina are among the highlights at this motel. Spend a day at the beach kayaking, or relax with sun loungers and beach umbrellas. Enjoy ...
8.8/10 Excellent! (1,006 reviews)
Clean room, exceptional customer care, location was fantastic!

Reviewed on Jan 23, 2026

Opens in a new windowParmer's Resort
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

1319 Duval Street Key West FL
Fully refundable
$606 nightly
The price is $681 total per night from Feb 3 to Feb 4
$681 total
Feb 3 - Feb 4
Total with taxes and fees
This hotel features a full-service spa, 3 outdoor pools, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling ...
8.6/10 Excellent! (3,042 reviews)
location and amenities

Reviewed on Jan 27, 2026

Opens in a new windowSouthernmost Beach Resort and Guesthouses
Kingsail Resort

Kingsail Resort

7050 Overseas Highway Marathon FL
$188 nightly
The price is $211 total per night from Feb 11 to Feb 12
$211 total
Feb 11 - Feb 12
Total with taxes and fees
A marina and an outdoor pool are featured at this smoke-free motel. Guests will appreciate free perks like free self parking and WiFi in public areas. A terrace, ...
8.4/10 Very Good! (1,031 reviews)
Checking in was easy and our person as friendly. Room was clean. Only stayed the night . Definitely would come back

Reviewed on Jan 25, 2026

Opens in a new windowKingsail Resort
Casa Marina Key West, Curio Collection by Hilton

Casa Marina Key West, Curio Collection by Hilton

1500 Reynolds Street Key West FL
Fully refundableReserve now, pay when you stay
$507 nightly
The price is $571 total per night from Feb 8 to Feb 9
$571 total
Feb 8 - Feb 9
Total with taxes and fees
A private beach, a full-service spa, and 2 outdoor pools are all featured at this smoke-free resort. Relax with sun loungers and beach umbrellas, and cool off ...
8.2/10 Very Good! (517 reviews)
Beautiful historic hotel, room was spacious, lots of amenities, friendly staff, terrific views, can walk to town.

Reviewed on Jan 20, 2026

Opens in a new windowCasa Marina Key West, Curio Collection by Hilton
Don't see what you're looking for?
See all available properties in Florida Keys
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Florida Keys

5 star hotels in Florida Keys

Florida Keys Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Florida Keys luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Florida Keys to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Florida Keys will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Florida Keys, and plan your next opulent escape.


Florida Keys hotels essential information

Accommodation
8,403 hotels
Lowest Price
$211
Highest Price
$1,067
Popular hotels
Oceans Edge Key West Resort, Hotel & Marina, The Marker Key West Harbor Resort, Cheeca Lodge & Spa, Casa Marina Key West, Curio Collection by Hilton, Kingsail Resort, Southernmost Beach Resort and Guesthouses, Parmer's Resort, H2O Suites - Adults Only

Popular Luxury Stays in Florida Keys

Recent Florida Keys Hotel Reviews By Fellow Wanderers