Explore top 2025 5 Star Hotels in Mission District
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Top Mission District 5 Star hotels
Claremont Resort & Club
41 Tunnel Road, Berkeley, CA
$366 nightly
The price is $416 total per night from Oct 29 to Oct 30
$416 total
Oct 29 - Oct 30
Total with taxes and fees
This luxury hotel features 3 restaurants, 3 outdoor pools, and 8 outdoor tennis courts. Bring the family and enjoy the children's club, playground, and kid-friendly ...
8.6/10 Excellent! (1,027 reviews)
"The staff was super accomodating. When I mentioned that street noise from my initial room was a bit annoying , they immediately offered me a room away from the street. They aim to please."
Reviewed on Oct 19, 2025
Fairmont San Francisco
950 Mason Street Atop Nob Hill, San Francisco, CA
Fully refundableReserve now, pay when you stay
$265 nightly
The price is $311 total per night from Nov 21 to Nov 22
$311 total
Nov 21 - Nov 22
Total with taxes and fees
A full-service spa, 2 restaurants, and a gym are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, express ...
8.8/10 Excellent! (1,403 reviews)
"Obviously, this is a historic, classic, original Fairmont hotel. Friendly staffs, and great services. I have absolutely nothing negative to say about this property. Firmaont San Francisco, enough said."
Reviewed on Oct 13, 2025
Taj Campton Place
340 Stockton St, San Francisco, CA
Fully refundableReserve now, pay when you stay
$208 nightly
The price is $244 total per night from Oct 30 to Oct 31
$244 total
Oct 30 - Oct 31
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9/10 Wonderful! (1,017 reviews)
"My happy place."
Reviewed on Oct 16, 2025
Palace Hotel, a Luxury Collection Hotel, San Francisco
2 New Montgomery St, San Francisco, CA
Fully refundableReserve now, pay when you stay
$278 nightly
The price is $327 total per night from Nov 21 to Nov 22
$327 total
Nov 21 - Nov 22
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,006 reviews)
"Rooms are due for renovations. Tiny restrooms"
Reviewed on Oct 11, 2025
The Ritz-Carlton, San Francisco
600 Stockton St, San Francisco, CA
Fully refundableReserve now, pay when you stay
$363 nightly
The price is $427 total per night from Nov 21 to Nov 22
$427 total
Nov 21 - Nov 22
Total with taxes and fees
This luxury hotel features 2 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.2/10 Wonderful! (1,011 reviews)
"Excellent . Beautiful room"
Reviewed on Oct 16, 2025
Four Seasons Hotel San Francisco
757 Market St, San Francisco, CA
Fully refundableReserve now, pay when you stay
$415 nightly
The price is $488 total per night from Oct 30 to Oct 31
$488 total
Oct 30 - Oct 31
Total with taxes and fees
A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Families will appreciate kid-friendly dining and in-room childcare. Enjoy ...
9.4/10 Exceptional! (1,004 reviews)
"Restaurant has beautiful view of the city Staff all very friendly"
Reviewed on Oct 18, 2025
1 Hotel San Francisco
8 Mission St, San Francisco, CA
Fully refundableReserve now, pay when you stay
$374 nightly
The price is $440 total per night from Nov 21 to Nov 22
$440 total
Nov 21 - Nov 22
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the in-room fitness and perks like free WiFi. There's a ...
9/10 Wonderful! (463 reviews)
"This was definitely one of my best hotel stays. I love to travel and finding a place with such great service and a lovely aesthetic always makes the trip so much better. The staff is kind and helpful and the rooms are beautiful. A wonderful hotel that I will definitely return to."
Reviewed on Oct 16, 2025
Four Seasons Hotel San Francisco at Embarcadero
222 Sansome St, San Francisco, CA
Fully refundableReserve now, pay when you stay
$446 nightly
The price is $524 total per night from Nov 14 to Nov 15
$524 total
Nov 14 - Nov 15
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Families will appreciate the onsite laundry facilities and in-room childcare. Traveling on ...
9.4/10 Exceptional! (1,008 reviews)
"Great"
Reviewed on Oct 16, 2025
The St. Regis San Francisco
125 3rd St, San Francisco, CA
Fully refundableReserve now, pay when you stay
$474 nightly
The price is $559 total per night from Oct 31 to Nov 1
$559 total
Oct 31 - Nov 1
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
9.2/10 Wonderful! (684 reviews)
"We convened for breakfast and after 20 minutes, they brought a high chair. We ordered bread toast, which was served along with the bill at the conclusion of our meal. As we were loading our car with luggage, no assistance was offered, despite the clear observation that we were accompanied by young ..."
Reviewed on Sep 21, 2025
Hotel Drisco
2901 Pacific Avenue, San Francisco, CA
$566 nightly
The price is $658 total per night from Nov 13 to Nov 14
$658 total
Nov 13 - Nov 14
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast and free WiFi. Business travelers can take advantage of the business center. ...
9.8/10 Exceptional! (449 reviews)
"Very good hotel area, room size , amenities , service"
Reviewed on Oct 14, 2025
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Mission District hotel reviews by fellow wanderers
Hyatt Regency San Francisco
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Been to SF more than 10 times - usually stay around union square for Moscone - but honestly this is now my fav hotel, amazing design, very unique architecture. Rooms well maintained, clean and appointed and super friendly and helpful staff, nothing was a problem and everything I asked for sorted quickly and hassle free. This isnt always the case in SF. Bonus this part of town is without all the hassles and troubles you find further up in Union square and surrounds - the walk to Moscone wasnt bad and the hotel made it worth it. Definitely will be back here if I can. "
A verified traveler stayed at Hyatt Regency San Francisco
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