Book Hotels in Santa Fe, FL
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Check prices for these dates
Top Santa Fe hotels

Drury Inn & Suites Gainesville
4000 Southwest 40th Blvd Gainesville FL
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $126 total per night from Apr 23 to Apr 24
$126 total
Apr 23 - Apr 24
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
It was a fine stay only the spa was under repair so we were not able to use it but that's just life, no real issues
Reviewed on Apr 15, 2026

Hotel Eleo at the University of Florida
1514 Southwest 14th Street Gainesville FL
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $201 total per night from Apr 19 to Apr 20
$201 total
Apr 19 - Apr 20
Total with taxes and fees
A restaurant and a gym are featured at this hotel. WiFi in public areas is free. Valet parking and luggage storage are also offered on site.
Perfect stay in every way!
Reviewed on Apr 15, 2026

Country Inn & Suites by Radisson, Gainesville, FL
4015 Sw 43rd St Gainesville FL
Fully refundable
$88 nightly
The price is $99 total per night from May 10 to May 11
$99 total
May 10 - May 11
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
I’d only suggest maybe a variety of things. We stay at least once per month and all stays have basically the same. This is of course regarding the breakfast. Thank you in advance!
Reviewed on Apr 14, 2026

Hyatt Place Gainesville Downtown
212 SE 1ST STREET, Gainesville FL
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $143 total per night from Apr 26 to Apr 27
$143 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
This hotel is always great! So convenient to the airport and centrally located in the downtown area. I've stayed here multiple times on business.
Reviewed on Apr 11, 2026

Hotel Indigo Gainesville-Celebration Pointe by IHG
5020 SW 30th Lane Gainesville FL
Fully refundable
$116 nightly
The price is $131 total per night from Apr 26 to Apr 27
$131 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Good location close to shops and restaurants
Reviewed on Apr 15, 2026

Sleep Inn & Suites University/Shands
4110 SW 40th Boulevard Gainesville FL
Fully refundable
$83 nightly
The price is $94 total per night from Apr 26 to Apr 27
$94 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Mattress needed to be replaced, had a huge dip in the middle of it.
Reviewed on Apr 16, 2026

HOM Hotel Gainesville, SureStay Collection by Best Western
3905 Sw 43Rd St Gainesville FL
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $87 total per night from Apr 22 to Apr 23
$87 total
Apr 22 - Apr 23
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Very clean and great staff
Reviewed on Apr 15, 2026

DoubleTree by Hilton Gainesville
3726 Sw 40th Blvd Gainesville FL
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $109 total per night from Apr 26 to Apr 27
$109 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the gym and perks like free self parking and free WiFi. A terrace, a garden, and a ...
As a mom traveling with a toddler… it was my worst nightmare getting into bed at midnight after a long drive only to find out that both beds were infested with bed bugs. I found this out after I put my son to bed. I had to wake my son up at midnight, book another hotel and had to pack up our belongings ...
Reviewed on Apr 15, 2026

Red Roof Inn PLUS+ Gainesville
3500 Southwest 42nd St Gainesville FL
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $68 total per night from Apr 19 to Apr 20
$68 total
Apr 19 - Apr 20
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Multilingual staff at the 24-hour front desk can provide around-the-clock ...
The rooms are outdated and the entire place could use a fresh coat of paint. The air conditioner was loud and the window very dirty.
Reviewed on Apr 16, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Santa Fe hotel reviews by fellow wanderers

Red Roof Inn PLUS+ Gainesville
3 out of 5
Posted 4 hours ago
Travelocity Verified Review
"The rooms are outdated and the entire place could use a fresh coat of paint. The air conditioner was loud and the window very dirty."
A verified traveler stayed at Red Roof Inn PLUS+ Gainesville
Explore More Ways to Travel with Travelocity
- Hotels near San Felasco Hammock Preserve State Park
- Hotels near North Florida Regional Medical Center
- Hotels near Plantation Oaks
- Hotels near Oaks Mall
- Waldo Hotels
- Brooker Hotels
- 3 Star Hotels in Alachua
- B&B in Alachua
- Cabins in Alachua
- Cottages in Alachua
- Extended Stay Hotels in Alachua
- Guest Houses in Alachua
- Cheap Hotels in Alachua
- Convention Center Hotels in Alachua
- Hotels with Pools in Alachua
- Pet Friendly Hotels in Alachua
- Alachua Hotels
- Motels in Alachua
- Rv Parks in Alachua
- Apartments in Jonesville
- Condos in Jonesville
- Cottages in Jonesville
- Jonesville Hotels
- Hotels near Waldo Motorsports
- Hotels near Ben Hill Griffin Stadium
- Hotels near Meadowbrook Golf Club
- Gainesville Hotels
- Apartments in High Springs
- B&B in High Springs
- Cabins in High Springs
- Condos in High Springs
- Cottages in High Springs
- Extended Stay Hotels in High Springs
- Guest Houses in High Springs
- La Quinta Inn & Suites Hotels in High Springs
- High Springs Hotels
- Motels in High Springs
- Vacation Homes in High Springs
- Resorts in High Springs
- La Crosse Hotels
- Hotels near Sante Fe College
- Hotels near O'Leno State Park
- Raiford Hotels
- Hotels near Ginnie Spring
- Hotels near Gainesville Raceway
- Hotels near Ruth B. Kirby Gilchrist Blue Springs State Park
- Hotels near Poe Springs Park
- Pet Friendly Hotels in Gateway Park
- Gateway Park Hotels
- Hotels near Devil's Milhopper Geological State Park
- Hotels near Dudley Farm Historic State Park
- Hotels near Ironwood Golf Course
- Apartments in Lulu
- Cabins in Lulu
- Extended Stay Hotels in Lulu
- Lulu Hotels
- Vacation Homes in Lulu
- Rv Parks in Lulu
- Hotels near Gainesville Regional
- Hotels near Santa Fe River
- Apartments in Lake Butler
- B&B in Lake Butler
- Cabins in Lake Butler
- Cottages in Lake Butler
- Lake Butler Hotels
- Motels in Lake Butler
- Hotels near Thomas Center
- Flights to Alachua
- Flights to Gainesville
- Flights to High Springs
- Flights from Fort Lauderdale to High Springs
- Flights from Hyderabad to High Springs
- Flights from Owensboro to High Springs
- Flights to Lulu
- Flights from Gainesville Regional
- American Airlines Charlotte (CLT) to Gainesville (GNV) flights
- Delta Atlanta (ATL) to Gainesville (GNV) flights
- Flights from Atlanta (ATL) to Gainesville (GNV)
- Flights from Nashville (BNA) to Gainesville (GNV)
- Flights from Fort Lauderdale (FLL) to Gainesville (GNV)
- Flights from New York (JFK) to Gainesville (GNV)
- Flights from Miami (MIA) to Gainesville (GNV)
- Flights from Chicago (ORD) to Gainesville (GNV)
- Flights from Tampa (TPA) to Gainesville (GNV)






