Book a hotel near Oregon Museum of Science and Industry, Southeast Portland
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Top hotels close to Oregon Museum of Science and Industry

Residence Inn by Marriott Portland Downtown/RiverPlace
2115 Sw River Pkwy Portland OR
Free Cancellation
Reserve now, pay when you stay
0.37 mi from Oregon Museum of Science and Industry
$127 nightly
The price is $147 total per night
$147 total
Dec 23 - Dec 24
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the free buffet breakfast each morning.

Hyatt House Portland/Downtown
2080 SW River Drive Portland OR
Free Cancellation
Reserve now, pay when you stay
0.39 mi from Oregon Museum of Science and Industry
$93 nightly
The price is $108 total per night
$108 total
Dec 25 - Dec 26
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. Enjoy the 24-hour gym and free on-the-go breakfast each morning.

AC Hotel by Marriott Portland Downtown, OR
888 Sw Third Ave Portland OR
Free Cancellation
Reserve now, pay when you stay
0.76 mi from Oregon Museum of Science and Industry
$101 nightly
The price is $117 total per night
$117 total
Dec 26 - Dec 27
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. A coffee shop, a snack bar/deli, and a library are also on offer.

The Duniway Portland A Hilton Hotel
545 SW Taylor St Portland OR
Free Cancellation
Reserve now, pay when you stay
0.89 mi from Oregon Museum of Science and Industry
$118 nightly
The price is $137 total per night
$137 total
Dec 30 - Dec 31
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. There's a 24-hour gym on site, and concierge services and wedding services are also offered.
Pool
Pet friendly

The Nines, a Luxury Collection Hotel, Portland
525 SW Morrison Street Portland OR
Free Cancellation
Reserve now, pay when you stay
0.93 mi from Oregon Museum of Science and Industry
$187 nightly
The price is $218 total per night
$218 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This luxury hotel's 2 restaurants, 2 bars/lounges, and 24-hour gym are some of the featured amenities. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, and valet parking. Enjoy the a rooftop terrace and perks like a free area shuttle.

Heathman Hotel
1001 SW Broadway Portland OR
Free Cancellation
Reserve now, pay when you stay
0.94 mi from Oregon Museum of Science and Industry
$151 nightly
The price is $175 total per night
$175 total
Dec 25 - Dec 26
Total with taxes and fees
This boutique hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. WiFi in public areas is free. Valet parking, a lobby fireplace, and a library are also offered.

The Royal Sonesta Portland Downtown
506 SW Washington St Portland OR
Free Cancellation
Reserve now, pay when you stay
0.97 mi from Oregon Museum of Science and Industry
$117 nightly
The price is $136 total per night
$136 total
Dec 22 - Dec 23
Total with taxes and fees
A restaurant and a 24-hour gym are featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. A lobby fireplace, express check-out, and dry cleaning are also on offer.
Pet friendly
Free WiFi

Embassy Suites by Hilton Portland Downtown
319 SW Pine St Portland OR
Free Cancellation
Reserve now, pay when you stay
0.99 mi from Oregon Museum of Science and Industry
$105 nightly
The price is $122 total per night
$122 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 2 hot tubs, and an indoor pool. Families will appreciate the arcade/game room and onsite laundry facilities. Enjoy the 24-hour gym and free perks like buffet breakfast and WiFi in public areas.

The Paramount Hotel
808 SW Taylor St Portland OR
Free Cancellation
Reserve now, pay when you stay
1.01 mi from Oregon Museum of Science and Industry
$99 nightly
The price is $114 total per night
$114 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. A computer station, dry cleaning, and luggage storage are also on offer.

Courtyard by Marriott Portland City Center
550 SW Oak Street Portland OR
Free Cancellation
Reserve now, pay when you stay
1.05 mi from Oregon Museum of Science and Industry
$94 nightly
The price is $109 total per night
$109 total
Dec 25 - Dec 26
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. A lobby fireplace, express check-in, and express check-out are also on offer.

Mark Spencer Hotel
409 Sw 11th Ave Portland OR
Free Cancellation
Reserve now, pay when you stay
1.23 mi from Oregon Museum of Science and Industry
$109 nightly
The price is $126 total per night
$126 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
A gym, self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Traveling on business? Take advantage of the business center, conference center, and conference space.
Pet friendly
Free WiFi

DoubleTree by Hilton Hotel Portland
1000 NE Multnomah Street Portland OR
Free Cancellation
Reserve now, pay when you stay
1.67 mi from Oregon Museum of Science and Industry
$119 nightly
The price is $138 total per night
$138 total
Dec 21 - Dec 22
Total with taxes and fees
This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Enjoy the seasonal outdoor pool and perks like free WiFi. Self parking, a 24-hour business center, and a coffee shop are also offered.
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See all available properties in Oregon Museum of Science and Industry
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Oregon Museum of Science and Industry hotels essential information
Accommodation | 2,426 hotels |
|---|---|
Lowest Price | $108 |
Highest Price | $218 |
Popular hotels | The Paramount Hotel, Embassy Suites by Hilton Portland Downtown, The Duniway Portland A Hilton Hotel, The Nines, a Luxury Collection Hotel, Portland, Hyatt House Portland/Downtown, AC Hotel by Marriott Portland Downtown, OR, DoubleTree by Hilton Hotel Portland, Heathman Hotel, Courtyard by Marriott Portland City Center, Mark Spencer Hotel, The Royal Sonesta Portland Downtown, Residence Inn by Marriott Portland Downtown/RiverPlace |
Recent Oregon Museum of Science and Industry hotel reviews by fellow wanderers

Hyatt House Portland/Downtown
5 out of 5
Posted 9 hours ago
Travelocity Verified Review
"Wonderful stay! Booked 2 rooms for the in laws & ourselves. Had a family member at OHSU. Rooms were king bed suites with a little kitchenette. Staff was amazing, indoor pool was a hit for our son, continental breakfast was great! Lots of choices for food. I was really surprised. Parking the hotel only offers valet, but not even a block down is a parking garage that we used. (Height of parking garage ceiling is 6’5”). Easy walk to the water front with a few stores & restaurants. Great stay & will definitely stay here again! "
A verified traveler stayed at Hyatt House Portland/Downtown
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