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Top hotels in Midtown

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street St. Louis MO
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $168 total per night from Feb 20 to Feb 21
$168 total
Feb 20 - Feb 21
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Room was spotless. Only problem was the shower pin would not stay up so we had to take baths.

Reviewed on Feb 11, 2026

Opens in a new windowDrury Plaza Hotel St. Louis at the Arch
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $106 total per night from Feb 21 to Feb 22
$106 total
Feb 21 - Feb 22
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport ...
Clean room. Great staff.

Reviewed on Feb 12, 2026

Opens in a new windowPear Tree Inn St. Louis Airport
Element St. Louis Midtown

Element St. Louis Midtown

3 out of 5
3763 Forest Park Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $158 total per night from Mar 8 to Mar 9
$158 total
Mar 8 - Mar 9
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and valet parking. Relax with a ...
Every single staff member that we spoke to was extremely nice and polite. Every part of the hotel was always clean, someone was mopping/cleaning the bathrooms in the lobby almost every time we were leaving or coming back in. The valet guys were great. They were polite, every time we left that told ...

Reviewed on Feb 16, 2026

Opens in a new windowElement St. Louis Midtown
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$138 nightly
The price is $162 total per night from Feb 22 to Feb 23
$162 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Everything was superlative. Staff, hotel, room, pool.

Reviewed on Feb 11, 2026

Opens in a new window21C Museum Hotel St Louis
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $122 total per night from Feb 26 to Feb 27
$122 total
Feb 26 - Feb 27
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Considering the price I wasn’t expecting such a nice place, from the entrance, to the easy parking, to the amazing breakfast… everything was so great and I would 1000% consider this place for my future stays in St. Louis! The staff was also very helpful and friendly!

Reviewed on Feb 12, 2026

Opens in a new windowClayton Plaza Hotel & Extended Stay
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $117 total per night from Mar 9 to Mar 10
$117 total
Mar 9 - Mar 10
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
Zero complaints! Enjoyed our stay and will stay again!

Reviewed on Feb 15, 2026

Opens in a new windowMagnolia Hotel St. Louis, a Tribute Portfolio Hotel
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $176 total per night from Feb 27 to Feb 28
$176 total
Feb 27 - Feb 28
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
The first room we got was not the cleanliest and was really rundown. So we called down to the front desk and got a second room, which was much better and you could tell was remodeled in the bathroom. Smelled clean, looked clean unlike first room.

Reviewed on Feb 11, 2026

Opens in a new windowHyatt Regency St. Louis at The Arch
Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

3 out of 5
525 S Jefferson Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $131 total per night from Feb 22 to Feb 23
$131 total
Feb 22 - Feb 23
Total with taxes and fees
A 24-hour gym, self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Traveling on business? Take advantage of the 3 ...
All good

Reviewed on Jan 20, 2026

Opens in a new windowResidence Inn by Marriott St Louis Downtown
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $103 total per night from Feb 17 to Feb 18
$103 total
Feb 17 - Feb 18
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Coffee!! And the breakfast. Both were fantastic! Room was clean and nice except for the heating. Didn’t get much sleep due to a very noisy heating unit. Friendly people at check in and out.

Reviewed on Feb 8, 2026

Opens in a new windowHeritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Midtown Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Midtown area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Midtown to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Midtown are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Midtown hotel reviews by fellow wanderers

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