Photo by Amber Palmer
Book a hotel near Mayo Clinic Florida, Southside
Seize Your Someday with our amazing deals for the whole family!
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top hotels close to Mayo Clinic Florida

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
14390 Mayo Boulevard, Jacksonville, FL
Free Cancellation
Reserve now, pay when you stay
0.19 mi from Mayo Clinic Florida
$161 nightly
The price is $183 total per night
$183 total
Oct 4 - Oct 5
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Relax with a drink at the bar/lounge and enjoy perks like free self parking.
Pool
Parking included

Hilton Jacksonville At Mayo Clinic
4745 Transformation Way, Jacksonville, FL
0.49 mi from Mayo Clinic Florida
$164 nightly
The price is $186 total per night
$186 total
Oct 8 - Oct 9
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the gym and perks like free self parking and a free area shuttle. Free WiFi in public areas, a grocery/convenience store, and express check-out are also on offer.
Pool
Parking included

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL
Free Cancellation
Reserve now, pay when you stay
0.67 mi from Mayo Clinic Florida
$171 nightly
The price is $194 total per night
$194 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the 24-hour gym and free perks like buffet breakfast and free self parking.
Pool
Breakfast included

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
0.75 mi from Mayo Clinic Florida
This vacation home features a garden, laundry facilities, and barbecue grills. There's fun for all ages with a playground and an arcade/game room.
Kitchen
Washer

Fancy private pool home in Jax beach
0.78 mi from Mayo Clinic Florida
$329 nightly
The price is $368 total per night
$368 total
Sep 16 - Sep 17
Total with taxes and fees
An outdoor pool is featured at this vacation home, along with laundry facilities and barbecue grills.
Pool
Kitchen

Dog-friendly waterfront home with private dock, boat lift, pool and spa
0.89 mi from Mayo Clinic Florida
This vacation home features a water park, a garden, and laundry facilities. Barbecue grills are provided for your convenience.
Pool
Kitchen

Peaceful Getaway Heated Pool Mayo Jags Games Beach
0.97 mi from Mayo Clinic Florida
This vacation home features a water park, a garden, and laundry facilities. Families will appreciate the arcade/game room and barbecue grills.
Pool
Kitchen

Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!
1.34 mi from Mayo Clinic Florida
$365 nightly
The price is $408 total per night
$408 total
Sep 22 - Sep 23
Total with taxes and fees
This vacation home features a water park, a garden, and laundry facilities.
Kitchen
Washer

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
4791 Windsor Commons Ct, Jacksonville, FL
Free Cancellation
1.66 mi from Mayo Clinic Florida
$122 nightly
The price is $138 total per night
$138 total
Sep 19 - Sep 20
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
13733 Beach Blvd, Jacksonville, FL
Free Cancellation
Reserve now, pay when you stay
1.92 mi from Mayo Clinic Florida
$118 nightly
The price is $134 total per night
$134 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included

TownePlace Suites by Marriott Jacksonville East
13741 BEACH BLVD, Jacksonville, FL
Free Cancellation
Reserve now, pay when you stay
1.92 mi from Mayo Clinic Florida
$114 nightly
The price is $129 total per night
$129 total
Sep 21 - Sep 22
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the laundry service and free internet in public areas. There's a gym on site, and laundry facilities and free newspapers are also offered.
Breakfast included
Pet friendly

Margaritaville Jacksonville Beach
715 1st St N, Jacksonville Beach, FL
Free Cancellation
Reserve now, pay when you stay
3.65 mi from Mayo Clinic Florida
$174 nightly
The price is $197 total per night
$197 total
Sep 16 - Sep 17
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. There's a gym on site, and a 24-hour front desk and a coffee shop are also provided.
Pool
Free WiFi
Don't see what you're looking for?
See all available properties in Mayo Clinic Florida
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Mayo Clinic Florida hotels essential information
Accommodation | 1,836 hotels |
---|---|
Lowest Price | $129 |
Highest Price | $408 |
Popular hotels | Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches, Residence Inn By Marriott Jacksonville - Mayo Clinic Area, Hilton Jacksonville At Mayo Clinic, Margaritaville Jacksonville Beach, Fancy private pool home in Jax beach, Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard, Dog-friendly waterfront home with private dock, boat lift, pool and spa, Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG, Peaceful Getaway Heated Pool Mayo Jags Games Beach, Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic, Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!, TownePlace Suites by Marriott Jacksonville East |
Recent Mayo Clinic Florida hotel reviews by fellow wanderers

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
5 out of 5
Posted 5 days ago
Travelocity Verified Review
"Everything went as expected. The Coffee station was not cleaned from a previous tenant."
A verified traveler stayed at Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Types of hotels
Hotels near…
Areas of Mayo Clinic Florida
Book on Expedia
More ways to wander Mayo Clinic Florida
Flights to Jacksonville
The best fares to get you there
Jacksonville Hotels
Jacksonville Vacation Rentals
Great Deals on Alternative Accommodations
Jacksonville Car Rentals
Affordable cars to get you around town
Jacksonville Vacations
Save more by combining flights, hotels and cars
Things to do in Jacksonville
Most popular
Hotels
- Hotels near Jacksonville Zoo and Gardens
- Hotels near River City Market Place
- Hotels near Jacksonville Naval Air Station
- Hotels near VyStar Veterans Memorial Arena
- Hotels near Logan Intl.
- Hotels near St. Johns Town Center
- Hotels near Daily's Place
- Hotels near Prime F. Osborn III Convention Center
- Hotels in Merewether
- Hotels near Mayport Naval Station
- Hotels near TPC Sawgrass
- Hotels in Centerville
- Hotels near University of North Florida
- Hotels near EverBank Stadium
- Extended Stay Hotels Hixson
- Hotels near Farmingdale State College
Flights
Cars
Packages
Vacation Rentals