Photo by Amber Palmer
Book a hotel near Mayo Clinic Florida, Southside
Seize Your Someday with our amazing deals for the whole family!
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top hotels close to Mayo Clinic Florida

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
14390 Mayo Boulevard, Jacksonville, FL
Free Cancellation
Reserve now, pay when you stay
0.19 mi from Mayo Clinic Florida
$161 nightly
The price is $183 total per night
$183 total
Jul 19 - Jul 20
Total includes taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Relax with a drink at the bar/lounge and enjoy perks like free self parking.
Pool
Parking included

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
0.55 mi from Mayo Clinic Florida
A water park and a gym are featured at this smoke-free vacation home. Families will appreciate the playground and onsite laundry facilities. A garden is also provided.
Kitchen
Washer

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL
0.67 mi from Mayo Clinic Florida
$175 nightly
The price is $199 total per night
$199 total
Jul 11 - Jul 12
Total includes taxes and fees
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the 24-hour gym and free perks like buffet breakfast and free self parking.
Pool
Breakfast included

Turquoise Oasis I Family & Dog Friendly I Saltwater Pool I Firepits
0.73 mi from Mayo Clinic Florida
A water park and an outdoor pool are featured at this smoke-free vacation home. Laundry facilities are provided for your convenience.
Pool
Kitchen

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
0.75 mi from Mayo Clinic Florida
This vacation home features a garden, laundry facilities, and barbecue grills. There's fun for all ages with a playground and an arcade/game room.
Kitchen
Washer

Fancy private pool home in Jax beach
0.78 mi from Mayo Clinic Florida
$564 nightly
The price is $632 total per night
$632 total
Jul 13 - Jul 14
Total includes taxes and fees
An outdoor pool is featured at this vacation home, along with laundry facilities and barbecue grills.
Pool
Kitchen

4BR Family Getaway Heated Pool 1 Level Near Mayo
0.97 mi from Mayo Clinic Florida
This vacation home features a water park, a garden, and laundry facilities. Families will appreciate the arcade/game room and barbecue grills.
Pool
Kitchen

Private in-law suite with full kitchen, washer/dryer, & central AC
1.39 mi from Mayo Clinic Florida
This vacation home includes a garden and laundry facilities.
Kitchen
Washer

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
4791 Windsor Commons Ct, Jacksonville, FL
Free Cancellation
1.66 mi from Mayo Clinic Florida
$125 nightly
The price is $142 total per night
$142 total
Jul 20 - Jul 21
Total includes taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
13733 Beach Blvd, Jacksonville, FL
Free Cancellation
Reserve now, pay when you stay
1.92 mi from Mayo Clinic Florida
$118 nightly
The price is $134 total per night
$134 total
Aug 3 - Aug 4
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
1220 Marsh Landing Pkwy, Jacksonville Beach, FL
Free Cancellation
Reserve now, pay when you stay
2.58 mi from Mayo Clinic Florida
$127 nightly
The price is $144 total per night
$144 total
Jul 13 - Jul 14
Total includes taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling for business? Take advantage of the free WiFi in public areas, express check-in, and conference space. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included

Margaritaville Jacksonville Beach
715 1st St N, Jacksonville Beach, FL
Free Cancellation
Reserve now, pay when you stay
3.65 mi from Mayo Clinic Florida
$156 nightly
The price is $178 total per night
$178 total
Aug 3 - Aug 4
Total includes taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. There's a gym on site, and a 24-hour front desk and a coffee shop are also provided.
Pool
Free WiFi
Don't see what you're looking for?
See all available properties in Mayo Clinic Florida
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Mayo Clinic Florida hotels essential information
Accommodation | 1,869 hotels |
---|---|
Lowest Price | $134 |
Highest Price | $632 |
Popular hotels | Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches, Residence Inn By Marriott Jacksonville - Mayo Clinic Area, Light Grey Getaway under 2 miles to mayo, 4 miles to the beach, Margaritaville Jacksonville Beach, Turquoise Oasis I Family & Dog Friendly I Saltwater Pool I Firepits, Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard, Fancy private pool home in Jax beach, 4BR Family Getaway Heated Pool 1 Level Near Mayo, Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG, Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area, Private in-law suite with full kitchen, washer/dryer, & central AC, Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic |
Recent Mayo Clinic Florida hotel reviews by fellow wanderers

Margaritaville Jacksonville Beach
5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Wonderful as always! "
A verified traveler stayed at Margaritaville Jacksonville Beach
Types of hotels
Hotels near…
Areas of Mayo Clinic Florida
Book on Expedia
More ways to wander
Flights to Jacksonville
The best fares to get you there
Jacksonville Hotels
Jacksonville Vacation Rentals
Great Deals on Alternative Accommodations
Jacksonville Car Rentals
Affordable cars to get you around town
Jacksonville Vacations
Save more by combining flights, hotels and cars
Things to do in Jacksonville
Most popular
Hotels
Hotels near Jacksonville Zoo and GardensHotels near River City Market PlaceHotels near Jacksonville Naval Air StationHotels near VyStar Veterans Memorial ArenaHotels near Logan Intl.Hotels near St. Johns Town CenterHotels near Daily's PlaceHotels near Prime F. Osborn III Convention CenterHotels in MerewetherHotels near Mayport Naval StationHotels near TPC SawgrassHotels in CentervilleHotels near University of North FloridaHotels near EverBank StadiumExtended Stay Hotels HixsonHotels near Farmingdale State College
Flights
Cars
Packages
Vacation Rentals