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Book a hotel near Mayo Clinic Florida, Jacksonville
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Top hotels close to Mayo Clinic Florida

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
14390 Mayo Boulevard Jacksonville FL
Free Cancellation
Reserve now, pay when you stay
0.19 mi from Mayo Clinic Florida
$161 nightly
The price is $183 total per night
$183 total
Dec 26 - Dec 27
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Relax with a drink at the bar/lounge and enjoy perks like free self parking.
Pool
Parking included

Hilton Jacksonville At Mayo Clinic
4745 Transformation Way Jacksonville FL
Free Cancellation
Reserve now, pay when you stay
0.49 mi from Mayo Clinic Florida
$122 nightly
The price is $139 total per night
$139 total
Dec 22 - Dec 23
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the gym and perks like free self parking and a free area shuttle. Free WiFi in public areas, a grocery/convenience store, and express check-out are also on offer.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
4905 SAN PABLO ROAD SOUTH Jacksonville FL
Free Cancellation
Reserve now, pay when you stay
0.67 mi from Mayo Clinic Florida
$149 nightly
The price is $169 total per night
$169 total
Dec 20 - Dec 21
Total with taxes and fees
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the 24-hour gym and free perks like buffet breakfast and free self parking.
Pool
Breakfast included

Fancy private pool home in Jax beach
Jacksonville FL
0.78 mi from Mayo Clinic Florida
$321 nightly
The price is $359 total per night
$359 total
Dec 21 - Dec 22
Total with taxes and fees
An outdoor pool is featured at this vacation home, along with laundry facilities and barbecue grills.
Pool
Kitchen

Comfy Mayo Retreat; Heated Pool, Close to Beach
Jacksonville Beach FL
0.98 mi from Mayo Clinic Florida
This vacation home features a water park, laundry facilities, and barbecue grills.
Pool
Kitchen

Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!
Jacksonville FL
1.34 mi from Mayo Clinic Florida
$359 nightly
The price is $402 total per night
$402 total
Dec 17 - Dec 18
Total with taxes and fees
This vacation home features a water park, a garden, and laundry facilities.
Kitchen
Washer

Quiet Coastal Home w/ Patio Near Beaches
Jacksonville FL
1.39 mi from Mayo Clinic Florida
Stay at this vacation home in Jacksonville Beach. Enjoy an in-room coffeemaker and air conditioning. Popular attractions St. Johns Town Center and Windsor Parke Golf Club are located nearby.
Washer
Dryer

Amazing Centrally Located Home in Peaceful Area
Jacksonville FL
1.58 mi from Mayo Clinic Florida
This vacation home features laundry facilities.

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
4791 Windsor Commons Ct Jacksonville FL
Free Cancellation
1.66 mi from Mayo Clinic Florida
$105 nightly
The price is $119 total per night
$119 total
Jan 2 - Jan 3, 2026
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
13733 Beach Blvd Jacksonville FL
Free Cancellation
Reserve now, pay when you stay
1.92 mi from Mayo Clinic Florida
$99 nightly
The price is $113 total per night
$113 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included

TownePlace Suites by Marriott Jacksonville East
13741 BEACH BLVD Jacksonville FL
Free Cancellation
Reserve now, pay when you stay
1.92 mi from Mayo Clinic Florida
$114 nightly
The price is $129 total per night
$129 total
Dec 21 - Dec 22
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the laundry service and free internet in public areas. There's a gym on site, and laundry facilities and free newspapers are also offered.
Breakfast included
Pet friendly

Margaritaville Jacksonville Beach
715 1st St N Jacksonville Beach FL
Free Cancellation
Reserve now, pay when you stay
3.65 mi from Mayo Clinic Florida
$159 nightly
The price is $180 total per night
$180 total
Dec 17 - Dec 18
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. There's a gym on site, and a 24-hour front desk and a coffee shop are also provided.
Pool
Free WiFi
Don't see what you're looking for?
See all available properties in Mayo Clinic Florida
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Mayo Clinic Florida hotels essential information
Accommodation | 1,860 hotels |
|---|---|
Lowest Price | $113 |
Highest Price | $402 |
Popular hotels | Hilton Jacksonville At Mayo Clinic, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches, Residence Inn By Marriott Jacksonville - Mayo Clinic Area, Margaritaville Jacksonville Beach, Fancy private pool home in Jax beach, Comfy Mayo Retreat; Heated Pool, Close to Beach, Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG, Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!, Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic, Quiet Coastal Home w/ Patio Near Beaches, TownePlace Suites by Marriott Jacksonville East, Amazing Centrally Located Home in Peaceful Area |
Recent Mayo Clinic Florida hotel reviews by fellow wanderers

Margaritaville Jacksonville Beach
5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Everything was great, beautiful property!!!"
A verified traveler stayed at Margaritaville Jacksonville Beach
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